15839769 172 GAADADDApawwDGTVVEHIRVSRDLAVARLQLDRPl-hYYPGQYVNVHVPQc-PRRWRYLSPAIPADpNGriEFHVRVV 249 Mycobacterium tuber... 20092582 13 SGKCDLMA-----YRILEKEEIAPSVHRMIIEARDVakaakAGQFIILRIDe-rGERVPLTIADFEKE-KG--TVTVIYQ 83 Methanosarcina acet... 14521927 1 ----MLIV-----YKILEKREIAMRNTWYKVQAPHVakkvqPGQFVIVRAFq-nGERIPLTPVMWDRD-EG--WIVLIAF 67 Pyrococcus abyssi 14521153 1 -------M-----FKILHKERLAPGINLFEVEAPRIakhakPGQFVIIRLHe-rGERIPLTIADFDRD-KG--SITIVAQ 64 Pyrococcus abyssi 14590735 1 ----MVHMg----YKITDKRDLSPIDFFVEVEAPHIakawkPGQFVIFILHEr-GERVPMSVYKAENG-----RIGMFIR 66 Pyrococcus horikoshii 14591621 3 TNSGVFIM-----YKILEKKEIAMRNTWYKIYAPHVakkvqPGQFVIVRAFp-nGERIPLTPIMWDRE-EG--WIVLVAF 73 Pyrococcus horikoshii 15897528 1 ----------miYYEVIEKRKNVDNVYEIKIANFSVk--pKAGQYVSLILPS--KAEIPLGVGDYDED-----NNELRLY 61 Sulfolobus solfatar... 9297059 1 --MGGTAL-----NEIVKKVKIAEDVFDFWIHSPSVskearPGQFVVIRLHe-kGERIPLTVADTKPE-EG--LFRMVVK 69 Thermotoga maritima 15639723 1 -------M-----FSILEKKQFSPQVFYLKVHAPDIaknraAGQFVLVQLDDeyAERIPLTIADAHAD-EG--WIALVIQ 65 Treponema pallidum 15607054 1 ------------MYKVLRKERLTPKAVLLEVQDERAk-lVKPGQYALVQANEe-SEPIPLSFLDVKES-----SYTFLVE 61 Aquifex aeolicus 20092582 13 SGKCDLMA-----YRILEKEEIAPSVHRMIIEARDVakaakAGQFIILRIDe-rGERVPLTIADFEKE-KG--TVTVIYQ 83 Methanosarcina acet... 14521927 1 ----MLIV-----YKILEKREIAMRNTWYKVQAPHVakkvqPGQFVIVRAFq-nGERIPLTPVMWDRD-EG--WIVLIAF 67 Pyrococcus abyssi 14521153 1 -------M-----FKILHKERLAPGINLFEVEAPRIakhakPGQFVIIRLHe-rGERIPLTIADFDRD-KG--SITIVAQ 64 Pyrococcus abyssi 14590735 1 ----MVHMg----YKITDKRDLSPIDFFVEVEAPHIakawkPGQFVIFILHEr-GERVPMSVYKAENG-----RIGMFIR 66 Pyrococcus horikoshii 14591621 3 TNSGVFIM-----YKILEKKEIAMRNTWYKIYAPHVakkvqPGQFVIVRAFp-nGERIPLTPIMWDRE-EG--WIVLVAF 73 Pyrococcus horikoshii 15897528 1 ----------miYYEVIEKRKNVDNVYEIKIANFSVk--pKAGQYVSLILPS--KAEIPLGVGDYDED-----NNELRLY 61 Sulfolobus solfatar... 9297059 1 --MGGTAL-----NEIVKKVKIAEDVFDFWIHSPSVskearPGQFVVIRLHe-kGERIPLTVADTKPE-EG--LFRMVVK 69 Thermotoga maritima 15639723 1 -------M-----FSILEKKQFSPQVFYLKVHAPDIaknraAGQFVLVQLDDeyAERIPLTIADAHAD-EG--WIALVIQ 65 Treponema pallidum 15607054 1 ------------MYKVLRKERLTPKAVLLEVQDERAk-lVKPGQYALVQANEe-SEPIPLSFLDVKES-----SYTFLVE 61 Aquifex aeolicus
15839769 250 PGGLVSNAIVGEtRPGDR--WRLSGPHGAFRVDR-DGGDVLMVAGSTGLAPLRALIIDLSR-FaVNPRVHLFFGARYACE 325 Mycobacterium tuber... 20092582 84 EMGKTTKQLA-K-LSAGDylEDFVGPLGTPADIRkLGT-VILVGGGVGVAPIYPQAKAYTSaG---NRVISIIGARNKDL 157 Methanosarcina acet... 14521927 68 TRGKTTMRMATE-LKEGDyiLNVAGPLGNPAPMEkFGK-VLAIGAYTGIVEVYPIAKAWQEiG---NDVTTLH-VTLEPM 141 Pyrococcus abyssi 14521153 65 EVGKTTKELG-T-YEEGDyiHDILGPLGNPSHVDkFGT-VVMVGGGVGVAEIYPVARAMKEkG---NYVISILGFRTKDL 138 Pyrococcus abyssi 14590735 67 KLGKTSLQLYYEfNVGDEf-YSMVGPLGKPIKVKyYGNVVFASDAVCGQAENYATLKAMKEvG---NYTISIQTFENAEN 142 Pyrococcus horikoshii 14591621 74 TKGKTTMKMAME-LKEGDeiLNVAGPLGNPAPMEkFGK-ILAIGAYVGIAEVYPIAKAWQEiG---NDVTTLH-VTFEPM 147 Pyrococcus horikoshii 15897528 62 VESEKLANEIGKr-------VILKGPLGKPLDFTnVRIIVGIAYGKLYHDLLYPLKVAYRSkIeTFAKCIDCKLNYEEPK 134 Sulfolobus solfatar... 9297059 70 VVGKTTHELS-L-KKEGDtiLDVVGPLGNPSEIEnYGN-VLLVGGGVGIATLYPIAKALKEaG---NNITTVLGARTKDY 143 Thermotoga maritima 15639723 66 TVGATTMRLC-E-KEVGDsiSVVLGPLGNPTLIEnVGT-VACVAGGVGAAPLYPIAQAHKRaG---NHVIVILGARNRDL 139 Treponema pallidum 15607054 62 VGGRATLEIAEL-VEEKI--QFIEAPCGSPFPVKnYGK-VLLISKNWGVAPLINIGRALKEeS---NEIYFVHVAEDEER 134 Aquifex aeolicus 20092582 84 EMGKTTKQLA-K-LSAGDylEDFVGPLGTPADIRkLGT-VILVGGGVGVAPIYPQAKAYTSaG---NRVISIIGARNKDL 157 Methanosarcina acet... 14521927 68 TRGKTTMRMATE-LKEGDyiLNVAGPLGNPAPMEkFGK-VLAIGAYTGIVEVYPIAKAWQEiG---NDVTTLH-VTLEPM 141 Pyrococcus abyssi 14521153 65 EVGKTTKELG-T-YEEGDyiHDILGPLGNPSHVDkFGT-VVMVGGGVGVAEIYPVARAMKEkG---NYVISILGFRTKDL 138 Pyrococcus abyssi 14590735 67 KLGKTSLQLYYEfNVGDEf-YSMVGPLGKPIKVKyYGNVVFASDAVCGQAENYATLKAMKEvG---NYTISIQTFENAEN 142 Pyrococcus horikoshii 14591621 74 TKGKTTMKMAME-LKEGDeiLNVAGPLGNPAPMEkFGK-ILAIGAYVGIAEVYPIAKAWQEiG---NDVTTLH-VTFEPM 147 Pyrococcus horikoshii 15897528 62 VESEKLANEIGKr-------VILKGPLGKPLDFTnVRIIVGIAYGKLYHDLLYPLKVAYRSkIeTFAKCIDCKLNYEEPK 134 Sulfolobus solfatar... 9297059 70 VVGKTTHELS-L-KKEGDtiLDVVGPLGNPSEIEnYGN-VLLVGGGVGIATLYPIAKALKEaG---NNITTVLGARTKDY 143 Thermotoga maritima 15639723 66 TVGATTMRLC-E-KEVGDsiSVVLGPLGNPTLIEnVGT-VACVAGGVGAAPLYPIAQAHKRaG---NHVIVILGARNRDL 139 Treponema pallidum 15607054 62 VGGRATLEIAEL-VEEKI--QFIEAPCGSPFPVKnYGK-VLLISKNWGVAPLINIGRALKEeS---NEIYFVHVAEDEER 134 Aquifex aeolicus
15839769 326 LYDLPTLWQIAAHnpwlSVSPVSEyn-gdPAWAAdypdvsaprglhvRQTGRLPDVVSRYGGW---GDRQILICGGPAMV 401 Mycobacterium tuber... 20092582 158 LILEDEMEKASS-----ELYIATDdg--skGHHG-------------FV----TDIMKKILDSg-eKVARVVIIGPPIMM 212 Methanosarcina acet... 14521927 142 VMLKEYFEKAVSRhi-vEPVKFDPdksfpENMKN-------------VTKAL-TGKVRELLETe--DWDLVFMVGPPGDQ 204 Pyrococcus abyssi 14521153 139 VFWEDKLRKVSD-----EVIVTTNdg--syGMKG-------------FT----THALQKLIDEg-rKIDLVHAVGPAIMM 193 Pyrococcus abyssi 14590735 143 VYPEEFLAKPVAD----EHYLTTE-----DGSVG-------------IKGHY-LDIVKELIEKd--KVDIIFAGGKLGSL 197 Pyrococcus horikoshii 14591621 148 VILKDYFEKAVSRhi-vEPVKIDQeksfqENTKN-------------VTKAL-TAKVKELLDNe--NWDLVFMVGPPGDQ 210 Pyrococcus horikoshii 15897528 135 NIEDADLILVSAPl---QLLYELKi----PGEKTl-----------vYNRWVKMNCNLGVCGLcevKGKLTCIDGPFMRF 196 Sulfolobus solfatar... 9297059 144 LIMVDEFKEIS------DVLLVTDdg--saGMKG-------------VV----TDAMDKLFREr--KFDICWAVGPTIMM 196 Thermotoga maritima 15639723 140 IIFEEEMRALAD-----ELVIVTDdg--syGRKG-------------LV----TEPLRELCXRa-sCPQEVVAIGPPIMM 194 Treponema pallidum 15607054 135 VFLTKEASEISe-----EFLLFTE-----DGSLG-------------EEGNS-EWALGYFIENf-gKPDLIVSAGSNLDS 189 Aquifex aeolicus 20092582 158 LILEDEMEKASS-----ELYIATDdg--skGHHG-------------FV----TDIMKKILDSg-eKVARVVIIGPPIMM 212 Methanosarcina acet... 14521927 142 VMLKEYFEKAVSRhi-vEPVKFDPdksfpENMKN-------------VTKAL-TGKVRELLETe--DWDLVFMVGPPGDQ 204 Pyrococcus abyssi 14521153 139 VFWEDKLRKVSD-----EVIVTTNdg--syGMKG-------------FT----THALQKLIDEg-rKIDLVHAVGPAIMM 193 Pyrococcus abyssi 14590735 143 VYPEEFLAKPVAD----EHYLTTE-----DGSVG-------------IKGHY-LDIVKELIEKd--KVDIIFAGGKLGSL 197 Pyrococcus horikoshii 14591621 148 VILKDYFEKAVSRhi-vEPVKIDQeksfqENTKN-------------VTKAL-TAKVKELLDNe--NWDLVFMVGPPGDQ 210 Pyrococcus horikoshii 15897528 135 NIEDADLILVSAPl---QLLYELKi----PGEKTl-----------vYNRWVKMNCNLGVCGLcevKGKLTCIDGPFMRF 196 Sulfolobus solfatar... 9297059 144 LIMVDEFKEIS------DVLLVTDdg--saGMKG-------------VV----TDAMDKLFREr--KFDICWAVGPTIMM 196 Thermotoga maritima 15639723 140 IIFEEEMRALAD-----ELVIVTDdg--syGRKG-------------LV----TEPLRELCXRa-sCPQEVVAIGPPIMM 194 Treponema pallidum 15607054 135 VFLTKEASEISe-----EFLLFTE-----DGSLG-------------EEGNS-EWALGYFIENf-gKPDLIVSAGSNLDS 189 Aquifex aeolicus
15839769 402 RATKAALIAKG---------------------------------APPERIQHDPLSR 425 Mycobacterium tuberculosis CDC1551 20092582 213 KVGAGVASPYDveilvslnsimvdgtgmcggcrvtvggetkftcVDGPEFDARKVDF 269 Methanosarcina acetivorans C2A 14521927 205 KAVFNVVKEFGipmrvdlhpimvdgtgmcgacrvtvggeikfacVDGPEFDAYQVDW 261 Pyrococcus abyssi 14521153 194 KAVAELTKPYGiktvaslnpimvdgtgmcgacrvtvggeikfacVDGPEFDAHLVDW 250 Pyrococcus abyssi 14590735 198 AKLAELTRPYGiptyatvrqimvdgtgmcgscrilydgevkfacRDGPVFDAHKVDW 254 Pyrococcus horikoshii 14591621 211 KAVFEVVKKYGipmkvdlhpimvdgtgmcgacrvtvggevkfacVDGPEFDAYLVDW 267 Pyrococcus horikoshii 15897528 197 DDLVDYGKGVLk--------------------------------------------- 208 Sulfolobus solfataricus 9297059 197 KFCTLKAREFGvpiwvslnpimvdgtgmcgacrvtvsgqikfacVDGPEFRGEEVDW 253 Thermotoga maritima 15639723 195 KFCAETTRPFGirtvvslntimidgtgmcggcrvnvgseikfvcVDGPEFDGHQVDF 251 Treponema pallidum 15607054 190 QMINRFAEERNiphiamvnahildanglclacrvlvegqeklacIDGPWFDASKVDW 246 Aquifex aeolicus 20092582 213 KVGAGVASPYDveilvslnsimvdgtgmcggcrvtvggetkftcVDGPEFDARKVDF 269 Methanosarcina acetivorans C2A 14521927 205 KAVFNVVKEFGipmrvdlhpimvdgtgmcgacrvtvggeikfacVDGPEFDAYQVDW 261 Pyrococcus abyssi 14521153 194 KAVAELTKPYGiktvaslnpimvdgtgmcgacrvtvggeikfacVDGPEFDAHLVDW 250 Pyrococcus abyssi 14590735 198 AKLAELTRPYGiptyatvrqimvdgtgmcgscrilydgevkfacRDGPVFDAHKVDW 254 Pyrococcus horikoshii 14591621 211 KAVFEVVKKYGipmkvdlhpimvdgtgmcgacrvtvggevkfacVDGPEFDAYLVDW 267 Pyrococcus horikoshii 15897528 197 DDLVDYGKGVLk--------------------------------------------- 208 Sulfolobus solfataricus 9297059 197 KFCTLKAREFGvpiwvslnpimvdgtgmcgacrvtvsgqikfacVDGPEFRGEEVDW 253 Thermotoga maritima 15639723 195 KFCAETTRPFGirtvvslntimidgtgmcggcrvnvgseikfvcVDGPEFDGHQVDF 251 Treponema pallidum 15607054 190 QMINRFAEERNiphiamvnahildanglclacrvlvegqeklacIDGPWFDASKVDW 246 Aquifex aeolicus
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",