Conserved Protein Domain Family
ProP

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COG0477: ProP 
MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
Statistics
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PSSM-Id: 223553
View PSSM: COG0477
Aligned: 1535 rows
Threshold Bit Score: 28.5027
Threshold Setting Gi: 11499686
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320007   98 ICVGVF-----VAVGGFLFG--------YDTGLINSITSMNYVKSHVAPnh-----------------dSft-------- 139
gi 15616044  11 QCKGFNrnvrhFFLSSLLSN--------IGLGIFMVIYNYYIRELGYDEqv----------------------------- 53
gi 14521528  11 WNVFLL-----GLVSFLNDM--------SSEMIA--PIVPSYLTD--ILkig---------------------------- 45
gi 14590595  15 WNVFLL-----GLVSFLNDM--------SSEMIA--PIVPTYLTD--ILkmg---------------------------- 49
gi 15901440   4 FLERASi----LALSLVLITs-------FSISSALPAMFDYYQGYSKEQ------------------------------- 41
gi 19113685     --------------------------------------------------------------------------------
gi 3183340   39 LQAKGSacngnSHSLKHETNgasssnnnVAKSSSHDSFKAKPKNYDSTSnsnepisfnepdssnshhnnEsicnndnccr 118
gi 15601508   3 IHSSAP-----NRIAVPVIAltl---yaIAAGYLMSLVPLMLPHYQLES------------------------------- 43
gi 731422     6 ANHTLPeefeeVVVPEMLEK--------EVGAKVDVKPTLTTSSPAPSYielidp--------gvhnieIyaemy----- 64
gi 16122372   3 KTSSLF-----LLFGTLFSAg--------GYGATFLISAWFHSQGGNDi------------------------------- 38
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320007  140 -----aQQMSILVSFLSLGTFFGA-----LTAPFISDSY--------GRKp---------TIIFSTIFI-------FSIG 185
gi 15616044  54 --------nGRVIAMQAMATAIAL-----LPAGFISDQK--------GRKk---------MIFIGALLT--------AIS 95
gi 14521528  46 -----klASGSIMGLIESLSSLFKv-----LFGYISdk--------fRKRk---------aFVALGY----------LIS 88
gi 14590595  50 -----klASGSIMGLIESLSSLFKv-----IFGYISdv--------fRKRk---------tFVALGY----------LLS 92
gi 15901440  42 --------IELLVSLPSFGIMMML-----LLNGFLEKIF--------PER----------LQISLGLLI-------LSLS 83
gi 19113685     --------------------------------------------------------------------------------
gi 3183340  119 eiarrrSLSPLLILPLNFINAFSWgmieiPLLFLLRQELcaihynldPTQlspddpicrlAEITTGVSKv-----rAAFG 193
gi 15601508  44 ------DLASWLASVFYAGLLAGA-----LVAEPFVNRl--------GHR----------KAFVWCLSL-------LQLS 87
gi 731422    65 --nrpiYRVALFFSLFLIAYAYGLdg-niRYTFQAYATSsysqhsllSTVnc-------iKTVIAAVGQiffarlsDIFG 134
gi 16122372  39 -------dAGATLGMALFGTLIGV-----PLVGWFAGKLd-------ASR----------LAALAALIQ--------SCG 81
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320007  186 ---NSLQVGAG------------GITLLIVGRVI---------SGIGIG---------AISAVVPLYQAEA-TH---K-- 226
gi 15616044  96 ---LLLRSIFAg------------ESLLLMTAFM---------TGFFLA---------FIQVSAIPLLAEN-SSe----- 136
gi 14521528  89 ---TISKGALavt---------hswWDFLILRi---------lDRIGKG---------IRTAPRDALIAES-SEk-gKs- 135
gi 14590595  93 ---TIAKGALalt---------hswWDFLTLRi---------lDRIGKG---------IRTAPRDALIAES-SEk-gKs- 139
gi 15901440  84 ---GTAPFWYQay------------pFVFGTRLL---------FGLGLG---------MINAKAISIISER-YQg----- 124
gi 19113685     --------------------------------------------------------------------------------
gi 3183340  194 slaAFLGLFSTayygtmgdiygrRLVLFITVSFLllgdlwllyQSYAPKhpyf-vlfaAALKGLGGYISTVvASqnsFva 272
gi 15601508  88 ---IVVMPLLPya------------sVWLLARLV---------AGIAVAg--------IFVVVESWLLHGD-EQgraKrl 134
gi 731422   135 r-fSIMIVSIIfysm----gtiiESQAVNITRFAvggc--fyqLGLTGIilileviasDFSNLNWRLLALF-IPalpFii 206
gi 16122372  82 ---YFLLGSLSgg----------sGYLPHVAALL---------IGLGWG---------MFYIGGPMALSER-LTdt---- 125
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320007  227 ------SLRGAIISTYQW-----AITWGLLVSS---AVSQGTHArn-------------dASSYRI--------PIGLQY 271
gi 15616044 137 ------kERVHLFSFNFA-----LIMIANVIGN---LLGGILTDaw--------------nVLWGVsmlssvrlTLLIGT 188
gi 14521528 136 ------GKSFGFHRMMDTl--------GAVAGP---LVAMGLLAllan---------ypkeLAYRY--------IFLISA 181
gi 14590595 140 ------GKSFGFHRMMDTl--------GAVTGP---LVAVGLLAllsk---------ypkeLAYRY--------IFLISA 185
gi 15901440 125 ------kRRIQMLGLRAS-----AEVVGASLIT---LAVGQLLAf-----------------gWTA--------IFLAYS 165
gi 19113685     --------------------------------------------------------------------------------
gi 3183340  273 dc-sktEFRAWYLGLNFA-----AYHLGTALGP---SLSGFIVQyt--------------pHMYYVfyi---tsTFWIIY 326
gi 15601508 135 giymvsLYGGTALGQMAIgqlgvAGAVPFIAITtllLIASIVLMyvds----------dqpSTQQAs-------SLSLRQ 197
gi 731422   207 ----ntWISGNVTSAIDAn---wKWGIGMWAFIlplACIPLGICmlhmrylarkhakdrlKPEFEAlnkl-kwkSFCIDI 278
gi 16122372 126 -------eRGPGFTRFSA-----FQMTGICGSP---ILLTIAVVqg--------------gIPIQA--------AFLLVG 168
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320007  272 VWSSFLA----IGM-----FFLPESPRYYvlkdkld---------------eaakslsFLRGVPVHDsglleelv----- 322
gi 15616044 189 ACFFAALw--pVLQieersKQANARHEDTsliqq---------------------mkqhrSSLKLIG------------- 232
gi 14521528 182 VPG--------VIGv------LIVLLLVKdkgsevk-------------------------------------------- 203
gi 14590595 186 IPG--------AIGv------LIVIFLVKdrggivk-------------------------------------------- 207
gi 15901440 166 AGFLVLPl---YLLfvpygKSKKEVKKRAke-------------------------asRLTREMKGli------------ 205
gi 19113685     --------------------------------------------------------------------------------
gi 3183340  327 LLYVWLIlp-eSLDvseskEQQNKISGFSsiwrsclepliilwprslcteescefhqyDINADTHAGrr----------- 394
gi 15601508 198 IFKLSKAamigCLVsgltlGAIYGLMPVEla--------------------------nRGISHTDLG------------- 238
gi 731422   279 AFWKLDIi--gMLLitvffGCVLVPFTLAgglkeewktahiivpevigwvvvlplymlWEIKYSRHPltpwdliqdrgif 356
gi 16122372 169 VMGVFAS----ILLmifgtREPLIRHENSlr--------------------------pWVKKITVLAk------------ 206
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320007  323 ------------eikatydyEASFGSS------------------------NFIDCFISSKs------------------ 348
gi 15616044 233 --------------------LFAIANVligf----------------gsglVIPYLNLYFTdrfdms------------- 263
gi 14521528 204 -------------kkikgisALKSSNLri---------------------fLVIVAIAAlgrysyaf------------- 236
gi 14590595 208 -------------kkikeisSLKSPHLra---------------------fLAVVAIAAlgrysyaf------------- 240
gi 15901440 206 -------------------fTLAIEAAvvvc----------------tntaITIRIPSLMVerglgd------------- 237
gi 19113685     --------------------------------------------------------------------------------
gi 3183340  395 ------------------hwDVLLAAIlisltl------------lgagsmGLLPLYTDYKfgwgpmk------------ 432
gi 15601508 239 --------------------NLMALVIlg--------------------gmAVQPLVPWLSkf----------------- 261
gi 731422   357 falliaffinfnwymqgdymYTVLVVAvhesiksatritslysfvsvivgtILGFILIKVRrtkpfiifgiscwivsfgl 436
gi 16122372 207 --------------------SGVIRPIvmvc-----------------lggAVFSGMMSFQdsltdg------------- 236
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320007  349 -----------rPKQTLRMFTGIALQAFQQFSGINF---------------------------IFYYGVNFFNKT----- 385
gi 15616044 264 ------tslvgiVLSMGQAMTAIALMVGPMVAHKYGe--------------------------VRAVVYLQLASLp---- 307
gi 14521528 237 ---------tlwkaeeLGYSVFQGLGFYALFNVIYa--------------------------lSAYPIGYYSDK------ 275
gi 14590595 241 ---------tlwkvkeLGYSIFQGLEFYALFNVIYa--------------------------lAAYPIGSYSDK------ 279
gi 15901440 238 ---------aqlssFVLSIMQLIGIVAGVSFSFLISifkekl---------------llwsgiTFGLGQIVIALSss--- 290
gi 19113685     --------------------------------------------------------------------------------
gi 3183340  433 --------aslilsTDSFASSITLVALFPLLSKVIEkiieklysseglfedpsradntsslqgIRNVFSYLVRPGysrs- 503
gi 15601508 262 ----------lgRTLQMALFCLLGTAAITLTVFDDS---------------------------LLVLGVSLFILGm---- 300
gi 731422   437 lvhyrgdsgahsGIIGSLCLLGFGAGSFTYVTQASIqasak------------------tharMAVVTSLYLATYnigsa 498
gi 16122372 237 ---------slasasTFFAVHATTAVVSRLLLAHKLss-----------------------wpRTPLVAVLLCCLmig-- 282
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320007  386 ----GVS-----------------NSYLVSFITYAVNVVF-----------NVPGL------------------------ 409
gi 15616044 308 ---fLLVaaft---------mnpwLAVLAFLFRQALMNAGnpiqmalmmrsVHPAMkgla-------------------- 355
gi 14521528 276 ------Vgkki---------iitiGFGIAGLASLIFAYANnl--------pTLLLAfvly-------------------- 312
gi 14590595 280 ------Vgkkk---------iittGFGIAGLASLLFAYSKsl--------aMLMLAfily-------------------- 316
gi 15901440 291 ---lWVVvagsv-------lagfaYSVVLTTVFQLVSERIpakllnqatsfAVLGCsfga-------------------- 340
gi 19113685     --------------------------------------------------------------------------------
gi 3183340  504 silrGRTadekytivkrdvwnaqlGYAIALSAAVLLAVAKsdvalftaviiQAISNmvvpcvqs-------------ial 570
gi 15601508 301 ----ATFalypiainlgcdkldasYIVSATQVMLLSYSVG-----------SVVGP------------------------ 341
gi 731422   499 fgssVSGavwtnilpkeiskrisdPTLAAQAYGSPFTFITtytwg-tperiALVMSyryvqkilciiglvfcfpllgcaf 577
gi 16122372 283 --lvCLLgipthv------sfqiaAAMLTGAGYGLLYPVIqtwavnesapeNRHAAltwf-------------------- 334
                       650       660       670       680       690       700       710
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320007  410 -----FFVEFFGR-------------------------------RKVLVVGGVIMTIANFIVAIVGCS-LK 443
gi 15616044 356 -nsvgQMVFQLGWavmgpvsagi-----------vvvygpytgyAIAFSMTAILYLIGSAYFFLVFRRvN- 413
gi 14521528 313 --glyMAIEDTIPraymadlakefekg---tvigayhtvfgvfvFPASIIVGYLWQTYSLTVGf-----LY 373
gi 14590595 317 --gvyMAIEDTIPraymadlakeyekg---tiigmyhtvfgifvFPASIIVGYLWQTYSLEIGf-----LY 377
gi 15901440 341 -fttpFVLGAIGLlth-------------------------ngmLVFSILGGWLIVISIFVMYLLQKRa-- 383
gi 19113685   1 ------------------------------------------------------------------DRaLY 5
gi 3183340  571 ngvqsEYNGRVLAafavfeavaliirgpiyafvytesmkvsypnMIFFLSAVIYGCCFIIIFFMRLYRpLN 641
gi 15601508 342 -----VLADCFMQdrhgl----------------------maylFAILLATCLYMLIKSVKTKRQWVAgE- 384
gi 731422   578 mlrnhKLTDSIALegndhl-------------------eskntfEIEEKEESFLKNKFFTHFTSSKDRkD- 628
gi 16122372 335 --vvaYFVGIFGFppfggwvlv--------------tvgkvwfiWVLATLATLELVTAIVKWPQTTHRpLS 389
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