Conserved Protein Domain Family
ProP

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COG0477: ProP 
MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
Statistics
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PSSM-Id: 223553
View PSSM: COG0477
Aligned: 1535 rows
Threshold Bit Score: 28.5027
Threshold Setting Gi: 11499686
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6320007   98 ICVGVF-----VAVGGFLFG--------YDTGLINSITSMNYVKSHVAPnh-----------------dSft-------- 139 baker's yeast
15616044  11 QCKGFNrnvrhFFLSSLLSN--------IGLGIFMVIYNYYIRELGYDEqv----------------------------- 53  Bacillus halodurans
14521528  11 WNVFLL-----GLVSFLNDM--------SSEMIA--PIVPSYLTD--ILkig---------------------------- 45  Pyrococcus abyssi
14590595  15 WNVFLL-----GLVSFLNDM--------SSEMIA--PIVPTYLTD--ILkmg---------------------------- 49  Pyrococcus horikoshii
15901440   4 FLERASi----LALSLVLITs-------FSISSALPAMFDYYQGYSKEQ------------------------------- 41  Streptococcus pneum...
19113685     -------------------------------------------------------------------------------- fission yeast
3183340   39 LQAKGSacngnSHSLKHETNgasssnnnVAKSSSHDSFKAKPKNYDSTSnsnepisfnepdssnshhnnEsicnndnccr 118 fission yeast
15601508   3 IHSSAP-----NRIAVPVIAltl---yaIAAGYLMSLVPLMLPHYQLES------------------------------- 43  Vibrio cholerae
731422     6 ANHTLPeefeeVVVPEMLEK--------EVGAKVDVKPTLTTSSPAPSYielidp--------gvhnieIyaemy----- 64  baker's yeast
16122372   3 KTSSLF-----LLFGTLFSAg--------GYGATFLISAWFHSQGGNDi------------------------------- 38  Yersinia pestis
6320007  140 -----aQQMSILVSFLSLGTFFGA-----LTAPFISDSY--------GRKp---------TIIFSTIFI-------FSIG 185 baker's yeast
15616044  54 --------nGRVIAMQAMATAIAL-----LPAGFISDQK--------GRKk---------MIFIGALLT--------AIS 95  Bacillus halodurans
14521528  46 -----klASGSIMGLIESLSSLFKv-----LFGYISdk--------fRKRk---------aFVALGY----------LIS 88  Pyrococcus abyssi
14590595  50 -----klASGSIMGLIESLSSLFKv-----IFGYISdv--------fRKRk---------tFVALGY----------LLS 92  Pyrococcus horikoshii
15901440  42 --------IELLVSLPSFGIMMML-----LLNGFLEKIF--------PER----------LQISLGLLI-------LSLS 83  Streptococcus pneum...
19113685     -------------------------------------------------------------------------------- fission yeast
3183340  119 eiarrrSLSPLLILPLNFINAFSWgmieiPLLFLLRQELcaihynldPTQlspddpicrlAEITTGVSKv-----rAAFG 193 fission yeast
15601508  44 ------DLASWLASVFYAGLLAGA-----LVAEPFVNRl--------GHR----------KAFVWCLSL-------LQLS 87  Vibrio cholerae
731422    65 --nrpiYRVALFFSLFLIAYAYGLdg-niRYTFQAYATSsysqhsllSTVnc-------iKTVIAAVGQiffarlsDIFG 134 baker's yeast
16122372  39 -------dAGATLGMALFGTLIGV-----PLVGWFAGKLd-------ASR----------LAALAALIQ--------SCG 81  Yersinia pestis
6320007  186 ---NSLQVGAG------------GITLLIVGRVI---------SGIGIG---------AISAVVPLYQAEA-TH---K-- 226 baker's yeast
15616044  96 ---LLLRSIFAg------------ESLLLMTAFM---------TGFFLA---------FIQVSAIPLLAEN-SSe----- 136 Bacillus halodurans
14521528  89 ---TISKGALavt---------hswWDFLILRi---------lDRIGKG---------IRTAPRDALIAES-SEk-gKs- 135 Pyrococcus abyssi
14590595  93 ---TIAKGALalt---------hswWDFLTLRi---------lDRIGKG---------IRTAPRDALIAES-SEk-gKs- 139 Pyrococcus horikoshii
15901440  84 ---GTAPFWYQay------------pFVFGTRLL---------FGLGLG---------MINAKAISIISER-YQg----- 124 Streptococcus pneum...
19113685     -------------------------------------------------------------------------------- fission yeast
3183340  194 slaAFLGLFSTayygtmgdiygrRLVLFITVSFLllgdlwllyQSYAPKhpyf-vlfaAALKGLGGYISTVvASqnsFva 272 fission yeast
15601508  88 ---IVVMPLLPya------------sVWLLARLV---------AGIAVAg--------IFVVVESWLLHGD-EQgraKrl 134 Vibrio cholerae
731422   135 r-fSIMIVSIIfysm----gtiiESQAVNITRFAvggc--fyqLGLTGIilileviasDFSNLNWRLLALF-IPalpFii 206 baker's yeast
16122372  82 ---YFLLGSLSgg----------sGYLPHVAALL---------IGLGWG---------MFYIGGPMALSER-LTdt---- 125 Yersinia pestis
6320007  227 ------SLRGAIISTYQW-----AITWGLLVSS---AVSQGTHArn-------------dASSYRI--------PIGLQY 271 baker's yeast
15616044 137 ------kERVHLFSFNFA-----LIMIANVIGN---LLGGILTDaw--------------nVLWGVsmlssvrlTLLIGT 188 Bacillus halodurans
14521528 136 ------GKSFGFHRMMDTl--------GAVAGP---LVAMGLLAllan---------ypkeLAYRY--------IFLISA 181 Pyrococcus abyssi
14590595 140 ------GKSFGFHRMMDTl--------GAVTGP---LVAVGLLAllsk---------ypkeLAYRY--------IFLISA 185 Pyrococcus horikoshii
15901440 125 ------kRRIQMLGLRAS-----AEVVGASLIT---LAVGQLLAf-----------------gWTA--------IFLAYS 165 Streptococcus pneum...
19113685     -------------------------------------------------------------------------------- fission yeast
3183340  273 dc-sktEFRAWYLGLNFA-----AYHLGTALGP---SLSGFIVQyt--------------pHMYYVfyi---tsTFWIIY 326 fission yeast
15601508 135 giymvsLYGGTALGQMAIgqlgvAGAVPFIAITtllLIASIVLMyvds----------dqpSTQQAs-------SLSLRQ 197 Vibrio cholerae
731422   207 ----ntWISGNVTSAIDAn---wKWGIGMWAFIlplACIPLGICmlhmrylarkhakdrlKPEFEAlnkl-kwkSFCIDI 278 baker's yeast
16122372 126 -------eRGPGFTRFSA-----FQMTGICGSP---ILLTIAVVqg--------------gIPIQA--------AFLLVG 168 Yersinia pestis
6320007  272 VWSSFLA----IGM-----FFLPESPRYYvlkdkld---------------eaakslsFLRGVPVHDsglleelv----- 322 baker's yeast
15616044 189 ACFFAALw--pVLQieersKQANARHEDTsliqq---------------------mkqhrSSLKLIG------------- 232 Bacillus halodurans
14521528 182 VPG--------VIGv------LIVLLLVKdkgsevk-------------------------------------------- 203 Pyrococcus abyssi
14590595 186 IPG--------AIGv------LIVIFLVKdrggivk-------------------------------------------- 207 Pyrococcus horikoshii
15901440 166 AGFLVLPl---YLLfvpygKSKKEVKKRAke-------------------------asRLTREMKGli------------ 205 Streptococcus pneum...
19113685     -------------------------------------------------------------------------------- fission yeast
3183340  327 LLYVWLIlp-eSLDvseskEQQNKISGFSsiwrsclepliilwprslcteescefhqyDINADTHAGrr----------- 394 fission yeast
15601508 198 IFKLSKAamigCLVsgltlGAIYGLMPVEla--------------------------nRGISHTDLG------------- 238 Vibrio cholerae
731422   279 AFWKLDIi--gMLLitvffGCVLVPFTLAgglkeewktahiivpevigwvvvlplymlWEIKYSRHPltpwdliqdrgif 356 baker's yeast
16122372 169 VMGVFAS----ILLmifgtREPLIRHENSlr--------------------------pWVKKITVLAk------------ 206 Yersinia pestis
6320007  323 ------------eikatydyEASFGSS------------------------NFIDCFISSKs------------------ 348 baker's yeast
15616044 233 --------------------LFAIANVligf----------------gsglVIPYLNLYFTdrfdms------------- 263 Bacillus halodurans
14521528 204 -------------kkikgisALKSSNLri---------------------fLVIVAIAAlgrysyaf------------- 236 Pyrococcus abyssi
14590595 208 -------------kkikeisSLKSPHLra---------------------fLAVVAIAAlgrysyaf------------- 240 Pyrococcus horikoshii
15901440 206 -------------------fTLAIEAAvvvc----------------tntaITIRIPSLMVerglgd------------- 237 Streptococcus pneum...
19113685     -------------------------------------------------------------------------------- fission yeast
3183340  395 ------------------hwDVLLAAIlisltl------------lgagsmGLLPLYTDYKfgwgpmk------------ 432 fission yeast
15601508 239 --------------------NLMALVIlg--------------------gmAVQPLVPWLSkf----------------- 261 Vibrio cholerae
731422   357 falliaffinfnwymqgdymYTVLVVAvhesiksatritslysfvsvivgtILGFILIKVRrtkpfiifgiscwivsfgl 436 baker's yeast
16122372 207 --------------------SGVIRPIvmvc-----------------lggAVFSGMMSFQdsltdg------------- 236 Yersinia pestis
6320007  349 -----------rPKQTLRMFTGIALQAFQQFSGINF---------------------------IFYYGVNFFNKT----- 385 baker's yeast
15616044 264 ------tslvgiVLSMGQAMTAIALMVGPMVAHKYGe--------------------------VRAVVYLQLASLp---- 307 Bacillus halodurans
14521528 237 ---------tlwkaeeLGYSVFQGLGFYALFNVIYa--------------------------lSAYPIGYYSDK------ 275 Pyrococcus abyssi
14590595 241 ---------tlwkvkeLGYSIFQGLEFYALFNVIYa--------------------------lAAYPIGSYSDK------ 279 Pyrococcus horikoshii
15901440 238 ---------aqlssFVLSIMQLIGIVAGVSFSFLISifkekl---------------llwsgiTFGLGQIVIALSss--- 290 Streptococcus pneum...
19113685     -------------------------------------------------------------------------------- fission yeast
3183340  433 --------aslilsTDSFASSITLVALFPLLSKVIEkiieklysseglfedpsradntsslqgIRNVFSYLVRPGysrs- 503 fission yeast
15601508 262 ----------lgRTLQMALFCLLGTAAITLTVFDDS---------------------------LLVLGVSLFILGm---- 300 Vibrio cholerae
731422   437 lvhyrgdsgahsGIIGSLCLLGFGAGSFTYVTQASIqasak------------------tharMAVVTSLYLATYnigsa 498 baker's yeast
16122372 237 ---------slasasTFFAVHATTAVVSRLLLAHKLss-----------------------wpRTPLVAVLLCCLmig-- 282 Yersinia pestis
6320007  386 ----GVS-----------------NSYLVSFITYAVNVVF-----------NVPGL------------------------ 409 baker's yeast
15616044 308 ---fLLVaaft---------mnpwLAVLAFLFRQALMNAGnpiqmalmmrsVHPAMkgla-------------------- 355 Bacillus halodurans
14521528 276 ------Vgkki---------iitiGFGIAGLASLIFAYANnl--------pTLLLAfvly-------------------- 312 Pyrococcus abyssi
14590595 280 ------Vgkkk---------iittGFGIAGLASLLFAYSKsl--------aMLMLAfily-------------------- 316 Pyrococcus horikoshii
15901440 291 ---lWVVvagsv-------lagfaYSVVLTTVFQLVSERIpakllnqatsfAVLGCsfga-------------------- 340 Streptococcus pneum...
19113685     -------------------------------------------------------------------------------- fission yeast
3183340  504 silrGRTadekytivkrdvwnaqlGYAIALSAAVLLAVAKsdvalftaviiQAISNmvvpcvqs-------------ial 570 fission yeast
15601508 301 ----ATFalypiainlgcdkldasYIVSATQVMLLSYSVG-----------SVVGP------------------------ 341 Vibrio cholerae
731422   499 fgssVSGavwtnilpkeiskrisdPTLAAQAYGSPFTFITtytwg-tperiALVMSyryvqkilciiglvfcfpllgcaf 577 baker's yeast
16122372 283 --lvCLLgipthv------sfqiaAAMLTGAGYGLLYPVIqtwavnesapeNRHAAltwf-------------------- 334 Yersinia pestis
6320007  410 -----FFVEFFGR-------------------------------RKVLVVGGVIMTIANFIVAIVGCS-LK 443 baker's yeast
15616044 356 -nsvgQMVFQLGWavmgpvsagi-----------vvvygpytgyAIAFSMTAILYLIGSAYFFLVFRRvN- 413 Bacillus halodurans
14521528 313 --glyMAIEDTIPraymadlakefekg---tvigayhtvfgvfvFPASIIVGYLWQTYSLTVGf-----LY 373 Pyrococcus abyssi
14590595 317 --gvyMAIEDTIPraymadlakeyekg---tiigmyhtvfgifvFPASIIVGYLWQTYSLEIGf-----LY 377 Pyrococcus horikoshii
15901440 341 -fttpFVLGAIGLlth-------------------------ngmLVFSILGGWLIVISIFVMYLLQKRa-- 383 Streptococcus pneumoniae TIGR4
19113685   1 ------------------------------------------------------------------DRaLY 5   fission yeast
3183340  571 ngvqsEYNGRVLAafavfeavaliirgpiyafvytesmkvsypnMIFFLSAVIYGCCFIIIFFMRLYRpLN 641 fission yeast
15601508 342 -----VLADCFMQdrhgl----------------------maylFAILLATCLYMLIKSVKTKRQWVAgE- 384 Vibrio cholerae
731422   578 mlrnhKLTDSIALegndhl-------------------eskntfEIEEKEESFLKNKFFTHFTSSKDRkD- 628 baker's yeast
16122372 335 --vvaYFVGIFGFppfggwvlv--------------tvgkvwfiWVLATLATLELVTAIVKWPQTTHRpLS 389 Yersinia pestis
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