Conserved Protein Domain Family
SerS

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COG0172: SerS 
Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
Statistics
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PSSM-Id: 223250
View PSSM: COG0172
Aligned: 70 rows
Threshold Bit Score: 267.927
Threshold Setting Gi: 15889830
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20094896  24 PTVEEFVKEaNEDLLQRG---VPTGKega--kiESYRVLEDTIEMEITGTRYLRPHEAAM--RVRKRLAERLGrkhRVGV 96
gi 3915062    1 MLDLKFIRD-NLDLVKRS---IKARG--------LVLDIDKLIYLDDKRKKLITKIGELN--AKRNENSSKMQ---ENLD 63
gi 19074152   4 INLIRDPK--TREKVVES---EKKRF-------RDGLAVGKAYELDRKRIEMNFRLDQIN--TRINQLNREIKsgyRQGK 69
gi 3122916   22 KNAVEEVLKnADSIFLKG---VPKGKeneaskiKSYEFEGNILKLKIASGTYTRAHEGLI--RLRKPLAEKLGrnfRIGV 96
gi 3122907   20 DDLEKFFTEaESDILRRG---VPEGQeheaahiKSWRLEGDTLHIEMESGRRVRAHDGLL--RLKKPLGQLLGpkyRVGV 94
gi 19115378  24 ILNYKYIYQ-NAEAVQRN---CINRNl-----qAIAETVPKIRSLIDEKESLKNEFFPLL--SLKKEITLQIE---RCSD 89
gi 3183173    4 INLFQVEKGgNPEIIRES---QRKRG-------ADVGVVDKVIEMYKEWVSLRFELDNTN--KSINRVQKEIG---LKMK 68
gi 6094414    1 MLDYRFIRE-NVDAVKEN---VKVRN--------VHADVDAIVHLYDQRVKLLAELQELQ--RARNENAQTMK---SSLD 63
gi 1711650    4 INQFIEDKGgNPELIRQS---QKARN-------ASVEIVDEIISDYKDWVKTRFELDELN--KKFNKLQKDIG---LKFK 68
gi 731635     1 MIIRRLFSIsNRSFFLKKpqfDVKKIiemipqyQTSIQNRELIEADSIIRSLQLLGERYQniKEIDKVIADIQiqrKSIE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20094896  97 RDLKip-rYEVVLRFDREVTRDDVGYVPVADDVVVEDG-TVRLTFQDVDEEMLRRHVIDRVIRLVAWAVE-ERSelverv 173
gi 3915062   64 KVLK------ISLIETGKILKKQLIDLEEELERVSVDFdLENKKVPNILSPDVPIGSSEEDNFEIKRVGVvP-------- 129
gi 19074152  70 NKEDg---DLSEKVAEIKGLSDEAKGLRDDVKAVEDELnKVMKGIGNIISPSVVVSNDEKDNPIVRSYRSsRNMqknp-- 144
gi 3122916   97 RGIEid-nYVITIETD-EDKAKKLEGIKVPECEAKVEGnKIILTFKDIGESELKRNIIDRAIKFVKTELEkEEEdltfkv 174
gi 3122907   95 RGISvt-dYTMEMKAPGVSGIPSLAELPFVEDAAITDG-TIMVRFQPLEESDLRKHVFDRVVKHARTLVE-SSDdltvqv 171
gi 19115378  90 PNER------GKLVNEAKGLKKKTEEYNKIISKVTNDLyQYCLAVPNTTLPTVPVG-PEDKAVVVQKIGSp--------- 153
gi 3183173   69 AKED-----ASELLEEKNSLTERKKNLIEQETAKNKEMlNVVSSIGNIVHDSVPVSMDEDNNEIIRKWAPeGVTvek--- 140
gi 6094414   64 ALAR------SACVETGRALKDRIAHSERLLVQISDQLlSATQALPNMTHMCTPHGRSDSDNLEIKRCGVpP-------- 129
gi 1711650   69 NKED-----ASGLLAEKEKLTQQKKELTEKEQQEDKDLkKKVFQVGNIVHPSVVVSNDEENNELVRTWKPeDLEavgpia 143
gi 731635    81 AQIKkdktKITEYSAALKALKEQYNDQNSKSSELKKKIlETCKSLPNTLDPTVPLDAPQIEQWINPLKTHk--------- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20094896 174 tkvepgtvVDESGP-REIRFDGDVTEEaRRRGWVKEFPGRGQWIYTPPMAALFEVLRDFLLERVTrKLGFEPALFPKLIP 252
gi 3915062  130 --------QFDFKP-KDHLELGRDLDL-LDFDRAREISGSKFYYLKNEAVFLEIALINFSLNKLR-DKGFDVFITPDVAR 198
gi 19074152 145 -----rpfCVLMKD-FTHSVAG------------AKVMGHRGYYLSGKMARLAQALTRYAIDFLE-NKGYTYIQTPVMLR 205
gi 3122916  175 ckippgtiVSEYKAkRKITFDKDPTDVaEKLGWVKKFPGRGQWFYTPPITALFRALEELIVEEVVkKIGFQECLFPKLIP 254
gi 3122907  172 tratpgeiIARSRS-RDFFFEGDPTEEaMRLGWVKKFPGRGQWFYGPKITALHRALEEFFIERIVkPLGFVECLFPKLIP 250
gi 19115378 154 -------lVKKTGSlKDHLQIANEG---INLEDAAQASGHSFCYTTGDIALLEMAITNYAMDFAI-SKGWCPVIPPTIVR 222
gi 3183173  141 ------knCLSHHE-VLTRLDGYDPE------RGVKVSGHRGYFLRQYGVFFNLALIQYGLDFLE-KRGYIALQAPTMLN 206
gi 6094414  130 --------CFSFSP-RDHVELARLLDI-VDFEAGKKVSGIKFYYLKREGVLLEQALIMFGLQFLQ-ERGFVPFLTPDIAR 198
gi 1711650  144 s-vtgkpaSLSHHE-ILLRLDGYDPD------RGVKICGHRGYFFRNYGVFLNQALINYGLQFLA-AKGYIPLQAPVMMN 214
gi 731635   152 ----------TSEA-QAHVDIMLKKNM-LDLQTASNVTGMSWYYLLNDGARLEQALVAYALKKAN-ENGFSSCVPPSITK 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20094896 253 LETMFRMRYLHG---LPDGMYYVCPPkrdpelfddfkrelyvwgelnertlgslkeklrdpGYVLAPAQCEPFYELLRDE 329
gi 3915062  199 EFIVDGIGFNPRg--NESNIYKIEDt-----------------------------------DKYLVGTSEITLGGYYYNK 241
gi 19074152 206 RDVMRKTSQLSD---FDDQLYKVED------------------------------------DLYLIATSEQSLAALYMDE 246
gi 3122916  255 LEIMYKMRYLEG---LPEGMYYVCPPkrepelfkefvnemmi---kkeipieklknllrdpGYVLAPAQCEPFYQFFEGE 328
gi 3122907  251 LDIMNKMRYLEG---LPEGMYYCSAPsrdpetfeefknelii---nrevpmdllkrgikdpGYVIAPAQCEPFYQFLSHE 324
gi 19115378 223 TDIALACGFQPRd-eEGQQIYELDSYtspl---------------------------vsspKQCLIGTAEISLAALGFKK 274
gi 3183173  207 KDVMAKTAQLEQ---FDEELYKVIDGd---------------------------------eERYLIATSEQPISAYHSGE 250
gi 6094414  199 EGMVCGLGFNPRg--SGSNIYRIEGe-----------------------------------HRCLVATAEITLGAYHAGE 241
gi 1711650  215 KELMSKTAQLSE---FDEELYKVIDGe---------------------------------dEKYLIATSEQPISAYHSGE 258
gi 731635   219 KELIDACGFNPRdmnNERQIYALQDTn-----------------------------------LGLVATAEIPLAGLGANK 263
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20094896 330 VVD--PERLPIKLYDCSgWTYRWEGGA----AKGLERVNEFQRIEHVWIAEPEEAERIREELLEATKRVAEELELEWKVV 403
gi 3915062  242 IID---LTLPIRMAGFS-HCFRKEAGAygqlSKGLYRVHQFSKVEMFCFCKAEESGVIHDEFLSIQEQIFTELEIPYRVL 317
gi 19074152 247 RMvp-qE-VPKKFCGQS-LCFRKEAGAhgkdNAGLFRVHQFEKIEQFVICGPEESQKYHEEMIKACEEFYQSLDISYNVV 323
gi 3122916  329 VID--VDK-PIMFFDRSgWTYRWEGGG----ARGLDRVNEFLRVECVWIGSPEFVEETRDKTLKYAEKLAEKLDLEYWVE 401
gi 3122907  325 VVS--AEDLPVKFFDRSgWTYRWEAGG----SKGLDRVHEFQRVELVWLAEPGETEEIRDRTVELSHDAADELELEWYTE 398
gi 19115378 275 TFN---NFTERKVVGVS-RAYRREAGArgkeNRGLYRLHEFTKVELFAWTHPSRSSEMFNEIVNFQKEFVETLKIPARIL 350
gi 3183173  251 WFEkpsEQLPLKYAGYS-TCYRREAGShgrdAWGIFRVHAFEKIEQFVLTDPEKSWEAFTEMINHAEDFYKSLELPYRIV 329
gi 6094414  242 VLEe--RSLPRLYAGLS-HCFRKEAGAagqfSRGLYRVHQFTKLEMFAYCTPSDSECLHERLRSLEEEIFTALEIPFRVV 318
gi 1711650  259 WFEkpqEQLPIHYVGYS-SCFRREAGShgkdAWGVFRVHAFEKIEQFVITEPEKSWEEFEKMISYSEEFYKSLKLPYRIV 337
gi 731635   264 VLElnSGECSKKLVGVS-RCYRAEAGArgkdTKGLYRVHEFTKVELFCWSKPETSAKVLEEIKQFQISVVEELGIPAKVL 342
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20094896 404 VsddpfYLEGrlledrDIELPDVPSYEFEVYLPFk-gERSSEEAWISVGSFNVHGEHFVDGFNVKEKSGR--TLFTGCAG 480
gi 3915062  318 N-----ICSF------DLGSPAYKKYDIEAWMPGrdgkGGYGEVTSTSNCTDYQSRRLKIRYKD-QDGQN--KFAHMVNG 383
gi 19074152 324 G-----IVSG------ELNDAAAIKYDLEAYFPS---AEKYRELVSCSNCTDYQSRELEIRYGVVKENNRk-IYVHLLNG 388
gi 3122916  402 VgddpfYLEGrkkedrGIEFPDVPKYEMRLWLPHi----KDERKGVAVTSANVHGTHFVEGFRIKDYKGR--RVWTGCTG 475
gi 3122907  399 VgddpfYLEGrkveerGIEFPDVPKYEMRLSLP-------GREKGVAVVSANVHGTHFIEGFSIREARNL--NIWTGCTG 469
gi 19115378 351 N-----MPTA------ELGSSASQKYDIEAWMPA---RQSYGEITSASNCLEYQARRLLTRYRN--DKDS--GFVHTLNG 412
gi 3183173  330 A-----IVSG------ALNNAAAKKYDLEAWFPF---QGEYKELVSCSNCTDYQSRNLEIRCGVKKMGDRekKYVHCLNS 395
gi 6094414  319 E-----VCAG------DLGAPAYRKWDLEAWMPGrq-gGSWGEVTSASNCTDYQARRLNVRYKD-AEGKK--HYVHMLNG 383
gi 1711650  338 G-----IVSG------ELNNAAAKKYDLEAWFPY---QKEYKELVSCSNCTDYQSRNLEIRCGIKKMGDRekKYVHCLNS 403
gi 731635   343 N-----MPSN------DLGNPAFKKYDIEAWMPG---RGKFGEISSASNCTDFQSRRLNTKYRDDNTGKL--EYVHTLNG 406
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|..
gi 20094896 481 LGVTRWVVGLLAQHGFEPEE-WPEPILERIDEkFGGLpe----vPKTLTWPE 527
gi 3915062  384 TAIATTRVIISILENFQDQK-GGVRIPKSLVK-YTG--------FDYIPFKN 425
gi 19074152 389 TMCAVQRALCCIVENYQTGD-G-IAIPDVLQG-YFGGd-----lIELGP--- 429
gi 3122916  476 YGITRWVVGYLAQYGFNFDD-WHP----IIKKkIKKLpe----vPQLITWPK 518
gi 3122907  470 IGLSRWIYGFLAQKGFETGN-WPD----FIGErVEGVe-----nPRIITWPR 511
gi 19115378 413 TAAAIPRLIIAILENHQQED-GTVKVPETLVP-YIH--------KEYLFKAK 454
gi 3183173  396 TLCATERALCCILENYQTPD-G-VNVPKVLQP-YMGGktf-lpfTKELPKNS 443
gi 6094414  384 TALAISRVLIALLENGQDAE-GRVRIPQALVP-FCG--------FEYLYPRV 425
gi 1711650  404 TLAATQRALCCILENYQTED-G-LVVPEVLRK-YIPGepeflpfVNELPKNS 452
gi 731635   407 TAMAIPRVIVALVENFYDPStGKISVPECLRE-FMNG-------QRYI---- 446
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