1ZRZ


Conserved Protein Domain Family
STKc_aPKC_iota

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cd05618: STKc_aPKC_iota (this model, PSSM-Id:88519 is obsolete and has been replaced by 270769)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C iota
Serine/Threonine Kinases (STKs), Atypical Protein Kinase C (aPKC) subfamily, iota isoform, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. There are two aPKC isoforms, zeta and iota. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions.
Statistics
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PSSM-Id: 88519
View PSSM: cd05618
Aligned: 4 rows
Threshold Bit Score: 650.585
Threshold Setting Gi: 527675
Created: 31-Aug-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #####   #            # #                                #               ## #  
1ZRZ_A       26 RVIGRGSYAKVLLVRLkktdRIYAMKVVKKELvndDEDIDWVQTEKHVFEQAsnHPFLVGLHSCFQTesRLFFVIEYVnG 105
gi 54037714 250 RVIGRGSYAKVLLVRLkkteRIYAMKVVKKELvndDEDIDWVQTEKHVFEQAsnHPFLVGLHSCFQTesRLFFVIEYVnG 329
gi 71896941 126 RVIGRGSYAKVLLVRLkkteRIYAMKVVKKELvndDEDIDWVQTEKHVFEQAsnHPFLVGLHSCFQTesRLFLVIEYVnG 205
gi 527675   250 RVIGRGSYAKVLLVRLkkteRIYAMKVVKKELvndDEDIDWVQQEKHVFEQAstIPFLVGLHSCFQTesRLFFVIEYVnG 329
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # #                                    # # ## #         ##  #             #####
1ZRZ_A      106 GDLMFHMQRqrkLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDseGHIKLTDYGMCKEGLRPGDTTSXFCGTP 185
gi 54037714 330 GDLMFHMQRqrkLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDseGHIKLTDYGMCKEGLRPGDTTSTFCGTP 409
gi 71896941 206 GDLMFHMQRqrkLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDseGHIKLTDYGMCKEGLRPGDTTSTFCGTP 285
gi 527675   330 GDLMFHMQRqrkLPEEHARFILAEISLALNYLHEHGIIYRDLKLDNVLLDseGHIKLTDYGMCKEGLGPGDTTSTFCGTP 409
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #                          #     #  #                                           
1ZRZ_A      186 NYIAPEILRGedyGFSVDWWALGVLMFEMMAGRSPFDIVgssdnpdqnTEDYLFQVILEKQIRIPRSmsVKAASVLKSFL 265
gi 54037714 410 NYIAPEILRGedyGFSVDWWALGVLMFEMMAGRSPFDIVgssdnpdqnTEDYLFQVILEKQIRIPRSlsVKAASVLKGFL 489
gi 71896941 286 NYIAPEILRGedyGFSVDWWALGVLMFEMMAGRSPFDIVgssdnpdqnTEDYLFQVILEKQIRIPRSlsVKAAGVLKSFL 365
gi 527675   410 NYIAPEILRGedyGFSVDWRALGVLMFEMMAGRSPFDIVgssdnpdqnTEDFLFQVILEKQIRIPRSlsVKAASVLKSFL 489
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1ZRZ_A      266 NkdPKERLGCLpqtGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNisgefgldNFDSQFTNERVQLXPDDDDivrkiDQS 345
gi 54037714 490 NkeSKERLGCHpqtGFADIMAHPFFRNVDWDLMEQKQVVPPFKPNisgefgldNFDAQFTNEPIQLTPDDDDavkkiDQS 569
gi 71896941 366 NkdPKERLGCHpqtGFADIQGHPFFRNVDWDLMEQKQVVPPFKPNisgefgldNFDSQFTNEPVQLTPDDDDivkkiDQS 445
gi 527675   490 NtdPKDRLGCHpqtGFADIQGHQFFRNVDWDLMEQKQVVPPFKPNisgefgldNFDAQFTNEPVQLTPDDEDvvrkiDQS 569

                ....*....
Feature 1                
1ZRZ_A      346 EFEGFEYIN 354
gi 54037714 570 EFEGFEYIN 578
gi 71896941 446 EFEGFEYIN 454
gi 527675   570 EFEGFEYIN 578

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