1K1D,1GKR


Conserved Protein Domain Family
Cyclic_amidohydrolases

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cd01302: Cyclic_amidohydrolases (this model, PSSM-Id:73256 is obsolete and has been replaced by 238627)
Click on image for an interactive view with Cn3D
Cyclic amidohydrolases, including hydantoinase, dihydropyrimidinase, allantoinase, and dihydroorotase, are involved in the metabolism of pyrimidines and purines, sharing the property of hydrolyzing the cyclic amide bond of each substrate to the corresponding N-carbamyl amino acids. Allantoinases catalyze the degradation of purines, while dihydropyrimidinases and hydantoinases, a microbial counterpart of dihydropyrimidinase, are involved in pyrimidine degradation. Dihydroorotase participates in the de novo synthesis of pyrimidines.
Statistics
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PSSM-Id: 73256
View PSSM: cd01302
Aligned: 10 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 6-Mar-2002
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitetetramer
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1K1D; Geobacillus stearothermophilus D-Hydantoinase
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  # #                                                                   
1K1D_A        48 CYVFPGGIDPHTHLDmplggt-vtkddFESGTIAAAFGGTTTIIDFCLtnkgep--lkkaieTWHNKAngk--------a 116
gi 15921266   45 KLLLPGGVDNHVHIYkrylkv-ptsdtVEKSTLAAAFGGTTTVIDFAFsdiq------pnveERIKQFsss--------- 108
gi 23113337   49 LLVLPGFIDQHVHFMdptet---dredFIHGTTAAAMAGVTTVIEHTHsrpil----tvedfLKYKSYieer-------s 114
gi 33595802   55 LWTLPGVIDPHVHFGfgsp-----etdFETESRNAALGGTTSVISFHRsadi------resfDAVRARaesq-------s 116
gi 17232502   61 LLGFPGVVDAHMHIGiyqp----ldkdAVTESKAAAMGGVTTSLNYIRtgqyy-----lnkgGSYRDFfpevlalsagnf 131
gi 22405230   54 LLAMPGFIDLHFHAGmgsin--svyndLKLESRAAVAGGYTYVRSHLIigedgksgylkvidHIIKNAekv--------s 123
gi 24216335   58 TVIFPGFGDIHIHARedesgkhtykedFVSASAAAVNGGVIHVADMPNnpippi--densysKKRKLAdrs--------- 126
1GKR_A        50 KFVMPGVVDEHVHIIdmdlk--nrygrFELDSESAAVGGITTIIEMPItfpptt--tldaflEKKKQAgqr--------l 117
gi 1709955  1461 LVRLPGLIDVHVHLRepggt---hkedFASGTAAALAGGITMVCAMPNtrppii--dgpalaLAQKLAeag--------a 1527
gi 3914514    51 LIVCPGFIDIHVHLRdpgqt---ykedIESGSRCAVAGGFTTIVCMPNtnpp-------idnTTVVNYi----------- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                                           
1K1D_A       117 viDYGFHLMISeitddvLEELPkvlee---egitSLXVFmayknvf----------------------------qaddgt 165
gi 15921266  109 yvNYTFHIFANd----vTDNLKkafd----igfnSVKFMmieyagl----------------------------kstlag 152
gi 23113337  115 lvDFGFAAHIWpg---qYDQLEklwq----egiaYFKVFtctthgvp---------------------------gqnsas 160
gi 33595802  117 ciDFGFHFGITsr--lhVDTLDeisrr---fgvsSYKLYmmykgaaglsk---------------------gftdiddgl 170
gi 17232502  132 fvDYSYHVAPIas--qhIDEIPllfee---hgvtSFKIFmfyggyglhglsdqqnlflminkeerydfahfefimrgvtr 206
gi 22405230  124 ysDFSFNPMIGtm--dqANELEelin----kginAYKIYynayqgeegrnl-------------------giyvdedidd 178
gi 24216335  127 niHITLYAGIGp----dTKPLKks---------vPYKVFmgpsigel--------------------------ffhnnqt 167
1GKR_A       118 kvDFALYGGGVpg---nLPEIRkmhd----agavGFXSMmaasvpgmf-------------------------davsdge 165
gi 1709955  1528 rcDFALFLGASsenagtLGTVAgs--------aaGLKLYlnetfsel--------------------------rldsvvq 1573
gi 3914514   110 -lQKSKSVGLCrv--lpTGTITkgrkgkeiadfySLKEAgcvaftddg-------------------------spvmdss 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           #                                                         #  
1K1D_A       166 lYCTLLAakel--galVMVHAEngdvidyltkkaladgntd-piyhaltrppelegeatgRACQltel-agsqLYVVHVt 241
gi 15921266  153 lKRINEFiner--qgyVMIHAEdeelisalsnnlrgspk-----lhlltrpdetelsaaiRAIPli-----enGLIAHVs 220
gi 23113337  161 lHGAFTKvasf--ggrVLVHCEddsltaenekvlkgnnrdd-ghviqewrskaaeaisvaNVCFiake-tgahVTIAHLs 236
gi 33595802  171 lWGALNAtrai-pgavLGVHCEnvevipwlrdplraagrdd-laawneqspdfleaenvhRVCYfagk-tgtpVNIVHLs 247
gi 17232502  207 lMAEYPEard---yisLSLHCEvaeilnaytkivendsslsglhaysaarpphseglaisIAAYlahetncanINLLHLs 283
gi 22405230  179 iVIKVLStaskyrktrIIFHAEdnstvkyctanerekngl---dafsrgrppfaeaikidHIGHlalh-fgakIHIAHIs 254
gi 24216335  168 lEDTISSyvg----enVSFHCEdpeilekhqnetfh----------edrrpaeaettatdFALYliek-ynlrGKLCHYs 232
1GKR_A       166 lFEIFQEiaac--gsvIVVHAEnetiiqalqkqikaaggkd-maayeasqpvfqeneaiqRALLlqke-agcrLIVLHVs 241
gi 1709955  1574 wMEHFETwps---hlpIVAHAEqqtv------------------------------aavlMVAQltq----rsVHICHVa 1616
gi 3914514   162 vMRKALElasq-lgvpIMDHCEddklaygvinegevsall--glssrapeaeeiqiardgILAQrtg----ghVHIQHVs 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #    
1K1D_A       242 caqAVEKIaearnk--gldvwGETCPQYLvldqsylekpnfegakYVWSPPLRekwhqeVLWNALkngqLQTLGSDQCSF 319
gi 15921266  221 sgkTLDLLpdk--------vkAEVVLHHLilskkvy--drrdsylFVTSPPVRdp---eEIWKRIn--kVSIIATDHNWF 285
gi 23113337  237 hpdVVGIVqeakea--gakvlAEICPQYLyleentl---aargsfGKFTPPSRsaresqELMELVgkgeLDILASDHAPS 311
gi 33595802  248 sreALREVrrhrhegraapiyVETCPHYLflddrs-----pagtyAKVNPPVRsaadidAMWEGVcdgaITTIGSDHVPR 322
gi 17232502  284 srkAMEAAlimqtafphinfrREVTVGHLlldvdt-----pngtwAKVNPPIRpradveYLWQAVlnhqVDWIVSDHACC 358
gi 22405230  255 sieAYEAVeryrnl--gvditIETEPHYLfyddsmw---rllgvfGKVNPPLRtsrdseFLIKKIserkIDSISSDVNAL 329
gi 24216335  233 tgeGLNKIkfakqk--gvkvtCEVTPTHLffdrsml--tpenrhwFQMNPPLRskedreRMLEGVkqgwIDYLATDHAPH 308
1GKR_A       242 npdGVELIhqaqse--gqdvhCESGPQYLnittdda---erigpyMKVAPPVRsaemniRLWEQLenglIDTLGSDHGGH 316
gi 1709955  1617 rkeEILLIkaakar--glpvtCEVAPHHLflshddl--erlgpgkGEVRPELGsrqdveALWEDMa--vIDCFASDHAPH 1690
gi 3914514   235 tklSLEIIeffkek--gvkitCEVNPNHLlfterev---lnsganARVNPPLRkkedrlALIEGVkrgiIDCFATDHAPH 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1K1D_A       320 dfkgqkelg--rgdftkipnGGPIIEDRVSILFSEGVKkgritlnqFVDIvSTRIAKLfglfpkk------gtivvgsDA 391
gi 15921266  286 dkevkenh----kefpdlvpGLPGVELRVPIILTEFIKrnlp-lykAIELlSENPAKInkldvg--------kidmgyRA 352
gi 23113337  312 tkrhkdsg-----siwtspfGLPGIDTTSSVMLTAVNNnkls-lagFVRMyAENPAKAlglypkk------gcirvgaDA 379
gi 33595802  323 kratkdk------diwaasnGFPGTGMILPILLHEGYHrrqvpletLMRVaSGASARIygmpakg-------riavgnDA 389
gi 17232502  359 saeqkrsakd-pnniwlaksGFGGTEYLLSGVVSEGSKrgms-ynhMAKLlSWNPSRRfglltkg-------diaigyDA 429
gi 22405230  330 nskqkiknankygniwdaspGFDNIQMTLPRLITKFVSsgilsyetLVYImSERPSQVigavnkg-------sisvgkDA 402
gi 24216335  309 sieek----------rkgtsGISQLDTYSLFVTWLVLKagve-lktVARIcAKNPGDFvneylpekfgkgfgriepgySA 377
1GKR_A       317 pvedkepgw---kdvwkagnGALGLETSLPMMLTNGVNkgrlslerLVEVmCEKPAKLfgiypqk------gtlqvgsDA 387
gi 1709955  1691 tleekc--------gsrpppGFPGLETMLPLLLTAVSEgrls-lddLLQRlHHNPRRIfh----------------lpPQ 1745
gi 3914514   310 qtfekel-------vefampGIIGLQTALPSALELYRKgiis-lkkLIEMfTINPARIigvdlg--------tlklgsPA 373
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
Feature 1                                                 
1K1D_A       392 DLVIFDPNiervisaethhma--vdynafegmkvtGEPVSV 430
gi 15921266  353 DLVIYDSEkkwrvsventhm---adwtpyegyeiiGKPDTI 390
gi 23113337  380 DLVLVDMKkkwtiqddgicsk--akwspfngfqctGKPVMT 418
gi 33595802  390 DLVIVDPDlektvdpgelesh--adyspyegmrlkGWPVRT 428
gi 17232502  430 DLVLVDPNesfvvraaesesq--qgytpfegmeltGRVKST 468
gi 22405230  403 DIVLVDDKnyhkatpellenvpgldwnpeinkeftGWPYKI 443
gi 24216335  378 NFTVLNLKkpkkflkeeiksk--sgwspfenfefpGSIEAV 416
1GKR_A       388 DLLILDLDidtkvdasqfrsl--hkyspfdgmpvtGAPVLT 426
gi 1709955  1746 EDTYVEVDlehewtipshmpfskahwtpfegqkvkGTVRRV 1786
gi 3914514   374 DITIFDPNkewilneetnlsk--srntplwgkvlkGKVIYT 412

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