1QLV,1MZJ,1EBL,1FJ8,1DD8


Conserved Protein Domain Family
decarbox_cond_enzymes

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cd00825: decarbox_cond_enzymes (this model, PSSM-Id:73238 is obsolete and has been replaced by 238421)
Click on image for an interactive view with Cn3D
decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new carbon-carbon bond by a decarboxylating Claisen-like condensation reaction. Members are involved in the synthesis of fatty acids and polyketides, a diverse group of natural products. Both pathways are an iterative series of additions of small carbon units, usually acetate, to a nascent acyl group. There are 2 classes of decarboxylating condensing enzymes, which can be distinguished by sequence similarity, type of active site residues and type of primer units (acetyl CoA or acyl carrier protein (ACP) linked units).
Statistics
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PSSM-Id: 73238
View PSSM: cd00825
Aligned: 7 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 6-Mar-2002
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedimer interface
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:catalytic triad
  • Structure:1FJ8; E.coli Beta-ketoacyl-[ACP] synthase I with bound inhibitor cerulenin
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1QLV_A      21 LATILAIGTAtppncvaqadyadyyfrvtksehmvdlkekfkricekt-aikkrylaltedylqenptmcefmapslnar 99   Gerbera hybrid c...
1MZJ_A      11 FSRVLGVGSYrprrevsnkevctwidstee--------------------------------------wietrtgirsrr 52   Streptomyces sp....
1EBL_A       2 YTKIIGTGSYlpeqvrtnadlekxvdtsde--------------------------------------wivtrtgirerh 43   Escherichia coli
1FJ8_A       3 RAVITGLGIVssignnqqevlaslregrsgitfsqelkd-------------------sgmrshvwgnvkldttglidrk 63   Escherichia coli
1DD8_A       3 RVVITGLGIVssignnqqevlaslregrsgitfsqelkd-------------------sgmrshvwgnvkldttglidrk 63   Escherichia coli
AAC38075    11 PIAIIGSGCRfakgastpeafwellragtdfvgpvpaerwdtaaiydesaaetgttyskvgaflehidrfdahyfgisas 90   Pseudomonas fluo...
P23156      15 RAVVTGLGVLsphgtgveahwkavadgtsslgpvtregca------------------hlplrvagevhgfdaaetvedr 76   Streptomyces coe...
Feature 1                                                                                      
1QLV_A     100 qdlvvtgVPMLGKEAAVKAIDewglp-----kskiTHLIFCTTAGvd----------------------------mpGAD 146  Gerbera hybrid c...
1MZJ_A      53 iaepdetIQVMGVAASRRALEhagvd-----paeiDLVVVSTMTNfvh---------------------------tpPLS 100  Streptomyces sp....
1EBL_A      44 iaapnetVSTXGFEAATRAIExagie-----kdqiGLIVVATTSAtha---------------------------fpSAA 91   Escherichia coli
1FJ8_A      64 vvrfmsdASIYAFLSMEQAIAdaglspeayqnnprVGLIAGSGGGsprfqvfgadamrgprglkavgpyvvtkamasGVS 143  Escherichia coli
1DD8_A      64 vvrfmsdASIYAFLSMEQAIAdaglspeayqnnprVGLIAGSGGGsprfqvfgadamrgprglkavgpyvvtkamasGVS 143  Escherichia coli
AAC38075    91 eakemdpQQRLLLEVACESVAragltre-qlkgsrTAVYVGMLGMdylalhsreagie------qinpyyaagkefsFAA 163  Pseudomonas fluo...
P23156      77 flvqtdrFTHFALSATQHALAdarfgradvdspysVGVVTAAGSGggefgqrelqnlwghg-srhvgpyqsiawfyaAST 155  Streptomyces coe...
Feature 1                            #                                                         
1QLV_A     147 YQLVKLLGlspsVKRYMLyqqGXAAGGTVLRLAKDLAEnnkgsRVLIVCSEItailfhgpne-----------------n 209  Gerbera hybrid c...
1MZJ_A     101 VAIAHELGad-nAGGFDLs-aACAGFCHALSIAADAVEsggsrHVLVVATERmtdvidl--------------------- 157  Streptomyces sp....
1EBL_A      92 CQIQSXLGik-gCPAFDVa-aACAGFTYALSVADQYVKsgavkYALVVGSDVlartcdp--------------------- 148  Escherichia coli
1FJ8_A     144 ACLATPFKi--hGVNYSIs-sACATSAHCIGNAVEQIQlgkqdIVFAGGGEElcwemacefdamgalstkyndtpekasr 220  Escherichia coli
1DD8_A     144 ACLATPFKi--hGVNYSIs-sACATSAHCIGNAVEQIQlgkqdIVFAGGGEElcwemacefdamgalstkyndtpekasr 220  Escherichia coli
AAC38075   164 GRIAYHLGv--hGPAMTVt-tACSSSLVAMHLACRALQageadMALAGGVNLmlapdltiymsqirai-----spsgrcr 235  Pseudomonas fluo...
P23156     156 GQVSIRNDf--kGPCGVVa-aDEAGGLDALAHAALAVRng-tdTVVCGATEAplapysivcqlgypelsr-atepdrayr 230  Streptomyces coe...
Feature 1                                                                                      
1QLV_A     210 hldslvaqALFGDGAAALIVGSGphlav--erpifEIVSTDQTILpdtekamklhlregg----------ltfqlhrdvp 277  Gerbera hybrid c...
1MZJ_A     158 --adrslsFLFGDGAGAAVVGPSdv---------pGIGPVVRGIDgtglgslhmssswdqyvedpsvgrpalvmdgkrvf 226  Streptomyces sp....
1EBL_A     149 --tdrgtiIIFGDGAGAAVLAASee---------pGIISTHLHADgsygelltlpnadrvnpe----nsihltxagnevf 213  Escherichia coli
1FJ8_A     221 tydahrdgFVIAGGGGMVVVEELehalargahiyaEIVGYGATSDgadmv------------------------------ 270  Escherichia coli
1DD8_A     221 tydahrdgFVIAGGGGMVVVEELehalargahiyaEIVGYGATSDgadmv------------------------------ 270  Escherichia coli
AAC38075   236 vfdaaadgIVRGEGCGVTVLKRLadalrdgdpiqaVIRGSAINQDgasagq----------------------------t 287  Pseudomonas fluo...
P23156     231 pfteaacgFAPAEGGAVLVVEEEaaarergadvraTVAGHAATFTgagrw------------------------------ 280  Streptomyces coe...
Feature 1                                    #                                    #            
1QLV_A     278 lmvaKNIENAAEKALSplgitdwnsvFWMVHPGGraILDQVERKLnlkedkl----rasrhvLSEYGNLISACVLFIIDE 353  Gerbera hybrid c...
1MZJ_A     227 rwavADVVPAAREALEvagltvgdlvAFVPHQANlrIIDVLVDRLgvpehv------vvsrdAEDTGNTSSASVALALDR 300  Streptomyces sp....
1EBL_A     214 kvavTELAHIVDETLAannndrsqldWLVPHQANlrIISATAKKLgxsxd-------nvvvtLDRHGNTSAASVPCALDE 286  Escherichia coli
1FJ8_A     271 apsgEGAVRCMKMAMHgvdt---pidYLNSHGTStpVGDVKELAAirevfgdk--spaisatKAMTGHSLGAAGVQEAIY 345  Escherichia coli
1DD8_A     271 apsgEGAVRCMKMAMHgvdt---pidYLNSHGTStpVGDVKELAAirevfgdk--spaisatKAMTGHSLGAAGVQEAIY 345  Escherichia coli
AAC38075   288 vpnaNAQAAVISQALKvaglsvddidYVEAHGTGtpLGDPIELSSldsafqgrerplwvgsvKANMGHLDAAAGMASVIK 367  Pseudomonas fluo...
P23156     281 aesrEGLARAIQGALAeagcrpeevdVVFADALGvpEADRAEALAladalgphaarvpvtapKTGTGRAYCAAPVLDVAT 360  Streptomyces coe...
Feature 1                                                                    
1QLV_A     354 VRKRsmaegkst--------------------------tgegldcGVLFGFGPGMTVETVVL 389  Gerbera hybrid cultivar
1MZJ_A     301 LVRSgavp---------------------------------gggpALMIGFGAGLSYAGQAL 329  Streptomyces sp. R1128
1EBL_A     287 AVRDgrik---------------------------------pgqlVLLEAFGGGFTWGSALV 315  Escherichia coli
1FJ8_A     346 SLLMlehgfiapsinieeldeq------aaglnivtettdrelttVMSNSFGFGGTNATLVM 401  Escherichia coli
1DD8_A     346 SLLMlehgfiapsinieeldeq------aaglnivtettdrelttVMSNSFGFGGTNATLVM 401  Escherichia coli
AAC38075   368 TMMVlkhaevpaqlhlaqlnplvdwkrsrlavptaieslpdrprlAGISGFGLSGTNVHMIL 429  Pseudomonas fluorescens
P23156     361 AVLAmehglipptphvldvch--------dldlvtgrarpaeprtALVLARGLMGSNSALVL 414  Streptomyces coelicolor

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