1G29,1B0U,1F3O,1OXV,1Z47


Conserved Protein Domain Family
ABC_Class3

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cd03229: ABC_Class3 (this model, PSSM-Id:72988 is obsolete and has been replaced by 213196)
Click on image for an interactive view with Cn3D
This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Statistics
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PSSM-Id: 72988
View PSSM: cd03229
Aligned: 28 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 27-Apr-2005
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
  • Structure:1OXV; Mg-ADP bound, 3.5A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                   ## ###                              
1G29_1        4 VRLVDVWKVfge---------vtaVREMSLEVKDgeFMILLGPSGCGKTTTLRMIagleepSRGQIYIGdklvadpekgi 74  Thermococcus lit...
1OXV_D        4 IIVKNVSKVfkkg-------kvvaLDNVNINIENgeRFGILGPSGAGKTTFMRIIagldvpSTGELYFDdrlvasngk-l 75  Sulfolobus solfa...
Q08381        1 MISARFSGRqg-----------dfTLDAAFDVPGqgVTALFGPSGCGKTTVLRCMagltrlPGGHLVVNgvtwqegrq-- 67  Rhodobacter caps...
CAA67644      4 LQLRAVVADr--------------RLDVEFSVSAgeVLAVLGPNGAGKSTALHVIagllrpRRGLGTFGgpgvdrhrgrg 69  Mycobacterium tu...
P31548        2 LKLTDITWLyh-----------hlPMRFSLTVERgeQVAILGPSGAGKSTLLNLIagfltpASGSLTIDgvdhttm---- 66  Escherichia coli
P95155        4 LQLRAVVADr--------------RLDVEFSVSAgeVLAVLGPNGAGKSTALHVIagllrpDAGLVRLGdrvltdteagv 69  Mycobacterium tu...
NP_635559     2 FTLDQVSRRygq---------aiaLDQVSLSFASgvTTALIGPSGAGKSTVLRMLvglewpDSGSVTFDgaplrrda--- 69  Xanthomonas camp...
P33594        4 LNISGLSHHyahggfngkhqhqavLNNVSLTLKSgeTVALLGRSGCGKSTLARLLvglespAQGNISWRgeplaklnr-a 82  Escherichia coli
NP_925194     2 IDVQAVSKRygq---------tvaLDPTSIACEAgsTTALIGPSGCGKSTLLRVVaglvipDSGTVSLAgetltaqn--- 69  Gloeobacter viol...
ZP_00052046  19 IRVRDLVVGfgh---------rtvMKGLDLDIRRgeILGFVGPSGQGKSVLTRTIlglvpkRSGTIEIFgedvdgltl-a 88  Magnetospirillum...
Feature 1                    #                                                                  
1G29_1       75 fvppkdrdIAMVFQsya--lypHMTVYDNIAFPlklrkvprqeidqrvre-----vaellgltellnrkpreLSGGQRQR 147 Thermococcus lit...
1OXV_D       76 ivppedrkIGMVFQtwa--lypNLTAFENIAFPltnmkmskeeirkrvee-----vakildihhvlnhfpreLSGGQQQR 148 Sulfolobus solfa...
Q08381       68 itpphrraVGYVFQeas--lftHLSVRENLVYGlrrargplriseaevt--------qllgidpllrrptatLSGGERQR 137 Rhodobacter caps...
CAA67644     70 ecgdprpsSRAAVArpv--vvsTPERGQKRGLRttmpsrdvwvrarartrasalrwlrevnaeqfadrkprqLSGGQAQR 147 Mycobacterium tu...
P31548       67 --ppsrrpVSMLFQenn--lfsHLTVAQNIGLGlnpglklnavqqgkmha-----iarqmgidnlmarlpgeLSGGQRQR 137 Escherichia coli
P95155       70 nvathdrrVGLLLQdpl--lfpHLSVAKNVAFGpqcrrgmfgsgrartrasa-lrwlrevnaeqfadrkprqLSGGQAQR 146 Mycobacterium tu...
NP_635559    70 -lqaqrqrIGYVIQegg--lfpHLDARSNVVLLaqtlgwtpqriaqrletl----calcqlppallarypaeLSGGQRQR 142 Xanthomonas camp...
P33594       83 qrkafrrdIQMVFQdsisavnpRKTVREILREPmrhllslkkseqlarase---mlkavdlddsvldkrppqLSGGQLQR 159 Escherichia coli
NP_925194    70 -serlrqnLGYVIQdgg--lfpHLSARDNVTLLarylkqspvaidrrvtel----gelvqipatalarfprqLSGGQRQR 142 Gloeobacter viol...
ZP_00052046  89 rrrqleqrWGVLFQqga--lfsGLTVKQNIQMPmrehlklserlldefarl---kiemvglkpdaadkypseLSGGMIKR 163 Magnetospirillum...
Feature 1                       ##                                #                   
1G29_1      148 VALGRAIVRkpQVFLMDEPLSNLDakLRVRMRAELKKLQrqlgvTTIYVTHDQVEAmtMGDRIAVMNrGV 217 Thermococcus litoralis
1OXV_D      149 VALARALVKdpSLLLLDEPFSNLDarMRDSARALVKEVQsrlgvTLLVVSHDPADIfaIADRVGVLVkGK 218 Sulfolobus solfataricus
Q08381      138 VAIGRALLSqpELLLMDEPLSALDriSRDEILPYLERLHaslqmPVILVSHDLSEVerLADTLVLMEaGR 207 Rhodobacter capsulatus
CAA67644    148 VAIARALAAepDVLLLDEPLTGLDvaAAAGIRSVLRSVVarsgcAVVLTTHDLLDVftLADRVLVLEsGT 217 Mycobacterium tuberculosis...
P31548      138 VALARCLVReqPILLLDEPFSALDpaLRQEMLTLVSTSCqqqkmTLLMVSHSVEDAarIATRSVVVAdGR 207 Escherichia coli
P95155      147 VAIARALAAepDVLLLDEPLTGLDvaAAAGIRSVLRSVVarsgcAVVLTTHDLLDVftLADRVLVLEsGT 216 Mycobacterium tuberculosis
NP_635559   143 VGLIRALMLdpPALLLDEPLGALDpiVRYDLQAQMRELFaqlgkTVVLVTHDVAEAayLADTLVLMRaGQ 212 Xanthomonas campestris pv....
P33594      160 VCLARALAVepKLLILDEAVSNLDlvLQAGVIRLLKKLQqqfgtACLFITHDLRLVerFCQRVMVMDnGQ 229 Escherichia coli
NP_925194   143 VGLMRALMNdpPIVLLDEPLGALDpiTRSELQTQLKAIFaglgkTVILVTHDMGEAayLAGRIALMRdGR 212 Gloeobacter violaceus PCC ...
ZP_00052046 164 AALARSLALdpEILFLDEPTSGLDpiGAGEFDDLVSTLKktlglTVFMVTHDLDSLytACDRIAALGdGR 233 Magnetospirillum magnetota...

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