1JI0


Conserved Protein Domain Family
ABC_TM1139_LivF_branched

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cd03224: ABC_TM1139_LivF_branched (this model, PSSM-Id:72983 is obsolete and has been replaced by 213191)
Click on image for an interactive view with Cn3D
LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.
Statistics
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PSSM-Id: 72983
View PSSM: cd03224
Aligned: 101 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 13-Dec-2004
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
  • Structure:ATP bound; 3.5A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          ## ###                                       
1JI0_A        7 LEVQSLHVYYGaihAIKGIDLKVPRGQIVTLIGANGAGKTTTLSAIAGlvraqkGKIIFNGQDItnkpah-----vinrx 81
gi 15807984   2 LKLEHVSAAYGqspVLFDIDLEVRDAEAVALIGRNGVGKSTLLRTISGlhpvtaGGVRLGGEAVehapaf-----arara 76
gi 17939117   2 LTLKNVHSYYGrshILHGVTLDVPTGKVTSILGRNSTGKTTLLKTLMAltdgmtGEMHLQGQDIssspth-----mrara 76
gi 19552160   2 LEITNLCAGYGrtqVLHSLSISTSSNGILSILGHNGAGKSTLLRTAVGlikptsGEVKLFGQDVtslsth-----ervkr 76
gi 27375304   5 LDIKHLDAGYGrsqVLFDVNLGIPWRGGVAVLGRNGAGKTTLMKTIVGelpawkGEVAFDGRDIsrratq-----ervra 79
gi 39935481   7 LNTVGLRAGYGgkpVLQGLEIEVREGEIIAVIGRNGVGKSTLMKSLIGlipamdGSIVFRGEPIehlpaf-----krarl 81
gi 40063655 613 LELKNIDTFYGkshILNSVSLDVSKGEVVALLGRNGAGKSSTLKSIMGiapiskGKILFNGREIqnmtpe-----qvarv 687
gi 45440840   2 LSLTAVNQYYGnnhILWDINLELPRGQCTCLIGRNGVGKTTLINCIMGhlpiksGTMIWQPHHEppqnlqqqpverrnal 81
gi 48785556   6 LDLQDVTSGYKasvVLRKLSMTVANGEAVAVLGKNGMGKTTLLKTIMGylpkkgGAIHVHGRDItrlpph-----qiara 80
gi 55376684   3 LELDEVSAAYDttpILRDVDLSVEEEEIVGVMGKNGVGKTTLLKTVMGllepseGTISYDGTDVthasad-----erara 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                                                         
1JI0_A       82 GIALVPEGRRIFPELTVYENLXXGaynrk-dkegiKRDLEWIFSL-FPRLKERlKQLGGTLSGGEQQXLAIGRALXSrPK 159
gi 15807984  77 GLAYVPQGRGLFSHLTVEENLLMGlsalggrpatkKEIPPLVYDL-FPICHDMrARKAGNLSGGQQQQVAIGRALVTrPA 155
gi 17939117  77 GIAYVPQGREIIPDFSIRENILMGafar----adrKREIPALVPElFPYLMANlDRPGGVLSGGQQQQLAIARALAAdPK 152
gi 19552160  77 GMAYVPQGQQSFTQLSCMENLQVVadlq---grvgKARIAEALDR-FPALTQVlDRQAGLLSGGQRQQLAIARALITaPK 152
gi 27375304  80 GIGYVPQEHSVFARLSVRDNLAVGsla-----sskADAVDHVLSI-FPKLGQRlDQPAGTLSGGERKMLAIGRAMLGdPK 153
gi 39935481  82 GIGYVPQGRDVFPRLSVAENIAVGasik---grltEQQRREVVDT-FPILGERwSQRAGTMSGGQQQQLAIGRVLVAdPE 157
gi 40063655 688 GVGLVPQGRRLFSNLTVEENLKVGglqrt-gdsgvTWPMERIVEK-FPRIKDRlHARADTLSGGEQQMVAIARALSGnVE 765
gi 45440840  82 GIGYVPQGQQIFSQLSVEDNLLVAvlag---rhksHPIPGWVFEL-FPLLHDKrSQRGGELTRNQQQQLAIARALVAePE 157
gi 48785556  81 GIAYAPQEHALFQDLSIRDNLRLGlsnv----svfEERFAGIEPV-FPVFKSRlRQYAGTLSGGEQKMLLVARALMTrPS 155
gi 55376684  78 GIGYIPQGRDVFPKLTVEQNIKMGetir---sesdETLYDQIYDY-FPVLEERaSQEAGTLSGGQQQMLAIGRALVSnPD 153
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1           ##                                #                                
1JI0_A      160 LLXXDEPSLGLAPILVSEVFEVIQKInq-eGTTILLVEQNALGALkvAHYGYVLETGQIVLEGkaSELLDN 229
gi 15807984 156 YLLLDEPTEGIQPSIVQDIEAALGRIraelRVAVLLVEQYLDFAWafADRYYVLQRGRVVESGltADVQPS 226
gi 17939117 153 VLLLDEPNEGIQPSIVEEIEKIIIRLnreiGMTIVLVEQNVAFARhaSHHFAMLEKGGVVAAGaiDALSDT 223
gi 19552160 153 LLLLDEPTEGIQPSVVAEIQQTIIDLak-dGMSIVLVEQNIGFALdaATSYAIVARGQVVESGqgAETTAE 222
gi 27375304 154 LLLLDEPTEGVWIGVIEEITERLIELa--kEIAVIIVEQHLDLALrvADYAYVLDRGRVALQGeaGEVRGN 222
gi 39935481 158 LILLDEPSEGIQPNIVQDIARDMVALnaktGVTIILVEQNLDMIRamAQRCYVMDKGRIVADLdrAALDDE 228
gi 40063655 766 MILMDEPFEGLSPTMIEELFESINDLr--sEVSLLIIEHQLDLVLalADRAFILDRGVVSHEGptRPLLED 834
gi 45440840 158 LLILDEPGSGTSPALSEDISTVLHQLsrnlGMTLLLVEHRLPFIQhiADRFCLMAGGRNVAQGtlDQLNEG 228
gi 48785556 156 IILLDEITEGLQPSVIDRLADALLWErkqhGTTLLLIEQNVPFALkvADRYAVLKQGEVIEHGnaKDETAE 226
gi 55376684 154 LLLLDEPSEGIQPSIVDQISQDMQTInddlGTTILFVEQNLGVIRemADRCYAMERGTVVDELgpSTIADE 224

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