Conserved Protein Domain Family
SGNH_arylesterase_like

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cd01839: SGNH_arylesterase_like (this model, PSSM-Id:58516 is obsolete and has been replaced by 238877)
SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.
Statistics
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PSSM-Id: 58516
View PSSM: cd01839
Aligned: 23 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 16-Aug-2004
Updated: 9-Mar-2011
Structure
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Aligned Rows:
Hierarchy
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Display:
 
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Citation:PMID 7773790

cd01839 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00229:SGNH_hydrolasecd01820:PAF_acetylesterase_likecd01821:Rhamnogalacturan_acetylesterase_likecd01822:Lysophospholipase_L1_likecd01823:SEST_likecd01824:Phospholipase_B_likecd01825:SGNH_hydrolase_peri1cd01826:acyloxyacyl_hydrolase_likecd01827:sialate_O-acetylesterase_like1cd01828:sialate_O-acetylesterase_like2cd01829:SGNH_hydrolase_peri2cd01830:XynE_likecd01831:Endoglucanase_E_likecd01832:SGNH_hydrolase_like_1cd01833:XynB_likecd01834:SGNH_hydrolase_like_2cd01835:SGNH_hydrolase_like_3cd01836:FeeA_FeeB_likecd01837:SGNH_plant_lipase_likecd01838:Isoamyl_acetate_hydrolase_likecd01839:SGNH_arylesterase_likecd01840:SGNH_hydrolase_yrhL_likecd01841:NnaC_likecd01842:SGNH_hydrolase_like_5cd01844:SGNH_hydrolase_like_6cd01846:fatty_acyltransferase_likecd01847:Triacylglycerol_lipase_likecd04501:SGNH_hydrolase_like_4cd04502:SGNH_hydrolase_like_7cd04506:SGNH_hydrolase_YpmR_like6746986529248091110004935114769131871196048885972777362107113954134888084454105272134706231147045481793716216263545929090701626355089067298324439898909314417549466735416321116120948712095167469865292480911100049351147691318711960488859727773621071139541348880844541052721347062311470454817937162162635459290907016263550890672983244398989093144175494667354163211161209487120951
cd01839 Sequence Cluster
cd01839 Sequence Cluster
Sub-family Hierarchy
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 cd01839 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                       #                
gi 4105272     4 SVLCFGDSLTWGsdaetgg----rhshddLWPSVLQKALgpd------------vkVIHEGLGGRTTAYDDhtad----- 62
gi 16263550    8 TVLCFGDSNTHGqvpgrgpl--dryrreqRWGGVLQGLLgpn------------wqVIEEGLSGRTTVHDDpieg----- 68
gi 87119604    3 KILCFGDSNTWGtkpegg-----ryddheRWSFLLGVYLnmpssdsinqeteskylVMEAGQPNRTLIKNApfd------ 71
gi 113954134   5 SILCFGDSNTWGmapdgsg----rlpfktRWPNRLQQILnqqnln------hqswnVIEQGLNSRTWVMDDplgavnygg 74
gi 89067298    3 TLLCFGDSNTHGsppangpgpyaryghgvRWPSVCAGALger------------weVIEEGLPGRTAQFDDpgmg----- 65
gi 88808445   10 TILCFGDSNTWGfnpdgsg----rfpqptRWPNQLERALnqtrp-------dlpwrTVEEGLNSRTWLHDDaigtanygg 78
gi 77362107    4 NILCFGDSNTWGlnpqtgk----rfsatvRWPAKLAVKLgan------------ftIIEAGQPNRALVNNPpfa------ 61
gi 88859727    3 KIICFGDSNTFGitpqgg-----rfnaneRWPTLLETLLnqttt-------skqfhVIEQGQPNRTLVHNPpfh------ 64
gi 114769131   6 RILVYGDSNSWGylddgs-----gerfqdRWPVEMDKHLsydl----------sitLIEECLPARTTNLADpelg----- 65
gi 110004935   4 NIATLGDSLTFGylpmgtg----kmadadNWPVKLENLLtkyyq-------treieIQTDAQPGRTIIKPLidfg----- 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     #                                                  
gi 4105272    63 -cdrNGARLLPTLLhshaPLDLVIIMLGTNDlkpsihg----------saivamKGVERLVKLVRNHvwqv------pdw 125
gi 16263550   69 -slkNGRIYLRPCLqshaPLDLIIIMLGTNDlkrrfnm----------ppsevaMGIGCLVHDIRELspgr-------tg 130
gi 87119604   72 -gdkSGLTYLKPLLai-hEPELVIIMLGTNDlkakfnl----------spadigAGAGTLIEQIQAFsqeai-----shs 134
gi 113954134  75 dyscNGRQDLSMILhsckPLNVVLLALGCNDckshlhl----------speeitSGAKILIHDIRMSyqcgp-----rys 139
gi 89067298   66 -ahmNGWPALRIALeshgPLDVLAVMLGTNDvktrfap----------tparvtAGIAGLLDIALSEamqe-------rh 127
gi 88808445   79 dyscSGRSGLMTALhshkPIDVVILALGCNDckgylnl----------saeqitAGARILIHDTRRAlncgpr---ldpp 145
gi 77362107   62 -gelSGVTYLQSYLne-lEIDLIIIDLGTNDlknrfsl----------nvhdiaAGLTALIDSILNFyeqs------nap 123
gi 88859727   65 -gdkSGLRYFKNCLld-hQPDLALIMLGTNDlkrkfcl----------daseiaSGLNALITASLALq------------ 120
gi 114769131  66 -ssfNGEATLEAVLlshqPLDHVLIMLGTNDlkakf-------------drninDIAEAIVNLAEIArstpagrggwfsd 131
gi 110004935  68 fpqdNGMDNLSVLYqkahPIDLFIIFLGTNDyfgydayaklkeipdyqietkivDSLGELVNKMESLhkdn------kek 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                            #  #        
gi 4105272   126 eAPDVLIVAPPqlc---etANPVMGAIFRDAIDESAMLAPVYRDLADDLd---cGFFDAGSVarttpvDGVHLDAENTRA 199
gi 16263550  131 nDPEIMIVAPPpm----leDLKEWESIFSGAQEKSRKLALEFEIMADSLe---aHFFDAGTVcqcspaDGFHIDEDAHRL 203
gi 87119604  135 sATKILLVSPPei-----kEVPPYVSVYAGGAQKSQLLAHEFATQAKQYq---cDFLDANQVikssdvDGIHWGAQAHES 206
gi 113954134 140 nHPPTIVLVTPgvi---qtTPQSLAWGFKGAAEKSRMLPSLYRNLAEQEs---vFFFDTQAIaetsplDGVHFGADQQDS 213
gi 89067298  128 gGLRVLLVAPPkv-----vLAGLDAGEFHGAEEVSAALPDHYRALAEARg---cAFLDANDVisvsplDGIHFDETAHGA 199
gi 88808445  146 tSPRIILMTPPai----riTPQSLTWGFEGAELKSQALAEHYCQLAAELd---vACFDVQPVanpstlDGVHFDAQAQAL 218
gi 77362107  124 gSPKILILSPAhv-----rEVGSYAGVYKGAEQKVVQLAAAFANVASIKq---cSFYDLARIvsvsneDGVHLDEKQHQK 195
gi 88859727  121 pALKVLIICPPpi-----lEVGSYAQIYLGGAVKSLALESAYQAVAKELn---cAFFAASSVvnscpiEGIHWSAKQHTQ 192
gi 114769131 132 qTPNVSVICPLiigqrvsdLKWDRFEEWVGAYEKSILLVDTLKRACNAVn---iNMIDGNQFgssselDPIHWDKENHQR 208
gi 110004935 142 vNYQVLVVCPPkv-----lTLHDGELLTSLPDAYQKYFAKLNIPVVNLQlaanpHPEDQSKY------DGIHYTSMETMA 210
                        250
                 ....*....|..
Feature 1                    
gi 4105272   200 IGRGLEPVVRMM 211
gi 16263550  204 LGEALAQEVLAI 215
gi 87119604  207 LALSIAEYIKQR 218
gi 113954134 214 IAAGLAELITAI 225
gi 89067298  200 LGKAVAEQVTRL 211
gi 88808445  219 IAAGLAACICQT 230
gi 77362107  196 ISDALETIIREF 207
gi 88859727  193 LAQALVKVVIEL 204
gi 114769131 209 FGQKMAKAIQAF 220
gi 110004935 211 VAQAIFDVIIAE 222

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