Conserved Protein Domain Family
Isoamyl_acetate_hydrolase_like

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cd01838: Isoamyl_acetate_hydrolase_like (this model, PSSM-Id:58515 is obsolete and has been replaced by 238876)
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Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases
BioAssay Targets and Results
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CID: 53364533
AID: 602351
GI: 27754071
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Late stage assay provider results from the probe development effort to identify inhibitors of diacylglycerol lipase, beta (DAGLb): LCMS-based animal-based Activity-Based Protein Profiling (ABPP) MudPIT selectivity analysis for ABHD6
Chemical Name: ML295
CID: 56593029
AID: 504519
GI: 27754071
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Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2
Chemical Name: SR-02000000996
CID: 56593033
AID: 504522
GI: 27754071
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Late stage assay provider results from the probe development effort to identify inhibitors of LYPLA1: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for anti-target ABHD11
Chemical Name: SR-02000001007
Statistics
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PSSM-Id: 58515
View PSSM: cd01838
Aligned: 36 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 30-Oct-2006
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Citation:PMID 7773790

cd01838 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00229:SGNH_hydrolasecd01820:PAF_acetylesterase_likecd01821:Rhamnogalacturan_acetylesterase_likecd01822:Lysophospholipase_L1_likecd01823:SEST_likecd01824:Phospholipase_B_likecd01825:SGNH_hydrolase_peri1cd01826:acyloxyacyl_hydrolase_likecd01827:sialate_O-acetylesterase_like1cd01828:sialate_O-acetylesterase_like2cd01829:SGNH_hydrolase_peri2cd01830:XynE_likecd01831:Endoglucanase_E_likecd01832:SGNH_hydrolase_like_1cd01833:XynB_likecd01834:SGNH_hydrolase_like_2cd01835:SGNH_hydrolase_like_3cd01836:FeeA_FeeB_likecd01837:SGNH_plant_lipase_likecd01838:Isoamyl_acetate_hydrolase_likecd01839:SGNH_arylesterase_likecd01840:SGNH_hydrolase_yrhL_likecd01841:NnaC_likecd01842:SGNH_hydrolase_like_5cd01844:SGNH_hydrolase_like_6cd01846:fatty_acyltransferase_likecd01847:Triacylglycerol_lipase_likecd04501:SGNH_hydrolase_like_4cd04502:SGNH_hydrolase_like_7cd04506:SGNH_hydrolase_YpmR_like1YZF A15673705569620184756453590962510583363942300310862515326604594056273330818404664552967007523515975893910177471131295066310144088853865507450115025489946125767407388499030581611105852946118012495279794964319511756144964646449652596464412423628752502561044964576829245712333486261YZF A1567370556962018475645359096251058336394230031086251532660459405627333081840466455296700752351597589391017747113129506631014408885386550745011502548994612576740738849903058161110585294611801249527979496431951175614496464644965259646441242362875250256104496457682924571233348626
cd01838 Sequence Cluster
cd01838 Sequence Cluster
Sub-family Hierarchy
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 cd01838 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                          #                             
1YZF_A        3 KIVLFGDSITAGYLde----avSPVLVDLVkrdiaamgleevaVINAGMPGDTTEDGLKRLNKEVLie---------kpD 69
gi 56962018   4 KLVCFGDSITAGHEglne-pmlTAFLKKKLppt--------veIINAGVSGDTTVQALARIVTDVIsh---------qpD 65
gi 58336394   2 RLLLTGDSIIARKEgkne-phiNWNLKQVLpk---------leIENTAVSGINSGAFLARLNELVLsvk--------qcD 63
gi 23003108   2 KLLLTGDSIIARPEnhsi-pelNFQLQKFLsc----------nIYNTAISGINSGGLALSLPNLVFnqp--------kcN 62
gi 62515326   2 RILLLGDSIFARKEgldq-priNWTLKEKKld---------leIDNTAVSGINSGALLALLGDLALkrp--------raG 63
gi 29245712   8 RIICLGDSISQYGWniae-ggfVGLLAEAYspk--------adVICRGLSGFTSEMLLHYMSNSNLldsldckgqstsiL 78
gi 90962510   3 NLVLFGDSITAGMTdgypspifSNEIRKYFpn---------ieILNRGVPGDHTDLALSRIQADILqs---------npD 64
gi 47564535   3 TLVCFGDSITADEMffngtprlTPRLREMFpn---------wnVVNAGVPGDNTFDALKRIKEDVLsh---------kpD 64
gi 33348626   3 HILLLGDSLTEWGFec----gwASRLSNVYvrr--------adVINRGLCGYNTRWILSILKNDESrhhllp-ayaprpL 69
gi 15673705   8 KITIFGDSITNGFGmde--ggsSNIIARLIekne-----pklkVVLHGINGDDTYGGLLRLKYVLEee----------aD 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                                       
1YZF_A       70 EVVIFFGANDASLdrn-----itVATFRENLETMIHEIg-----sEKVILITPPYADs------------------gRRP 121
gi 56962018  66 LVTVLFGANDVAThkr-----veQDDFAHNIDKIASLIs-----pKKTILITPAPVDesl--------------eqnRTN 121
gi 58336394  64 NLMILLGTNDLAThkq-----vpLNQFKQNMEFICSAVick-yypPHVLLISPPAVDeek--------------qhvRNN 123
gi 23003108  63 YLIILVGTNDLAThkq-----vpLRQFEKNLELIASSIiwl-yypEKVIFITPPAVDenk--------------qrvRNN 122
gi 62515326  64 QLFLMVGVNDAAShkq-----vpLDQYRKNLQAIVSALvcf-ypgTKTVLVSGPAVDeak--------------qrgRTN 123
gi 29245712  79 YVTVCIGANDASSsaqnpiqsvhISKYRKNLVDILRFIhaagvpyDRIIVLAPPPIAdpaqhp--------clhekgKSP 150
gi 90962510  65 IVTIFFGTNDVTAeg------pdYQTFITNIKEMITLIg-----tQKCILITPGITGpsl--------------qdfYPN 119
gi 47564535  65 FVTVFLGTNDAVSfsq-----gsLQAYKENLEKIVNHIs-----sGKVLLISPAPVDeer--------------qhnRTN 120
gi 33348626  70 FITLLLGSNDCATggq----avpLHEFKSNLRAIIDLVrkhaspvGGIFLMTPPPINvekwhkrlqrefgadpstcgRSL 145
gi 15673705  71 LNFIFFGANDASPyhl-----irPAEFRENLLKMISQLg-----vERTVLITPPFYNddep-------------thySKL 127
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                            #  #                 
1YZF_A      122 ERPQTRIKELVKVAQEVGaa-hnLPVIDLYkamtvypg--------tdeflqaDGLHFSQVGYELLGALIVREI 186
gi 56962018 122 EDLKAYSDCIKEIAQRRD-----CHFIDFFttffskpdy-----qwrlkgtmdDGLHFGEKGYDLLSDLIAEKI 185
gi 58336394 124 GLIKKYSETIQNIAEEYH-----FEYADLCqamleagdi-----kkisqgiknDGLHFGDLGYEILAKLIVENL 187
gi 23003108 123 RLVMEYGNIVKKVASEYK-----FSIIDLAskmqenknf-----peifngkknDGLHFGVNGYKLLANLIVKKI 186
gi 62515326 124 AKLAKYAKVMEEVAAEYQ-----VAYADFFtamlkegnl-----kalcrgeldDGLHFGPRGYQLLAAEMMKQL 187
gi 29245712 151 HLTEEYAQACLEIAKEVGar--pADVRLLWdkas---------------siwtDGLHMNRSGNRLLFQAIMDAC 207
gi 90962510 120 QKLSQYAQGLVTLAEELN-----VACYDWHsiateye---------asellqaDDIHYSKKAYELLVQGLAPLI 179
gi 47564535 121 EVLGQYADVVEEVAKETG-----SYFLNLYaemiqerny-----ktfvenderDGLHFGPEGYEYVAKLIGEKL 184
gi 33348626 146 ERVLSYRDAVLQVGCVEKkahndVHVVDLYerflgkdaespnvakgpwcdylsDGLHFSETGGALVFDALMSAI 219
gi 15673705 128 SEVELFREVILNLGKEKS-----LKVIDIFqimkssen--------pknllraDGLHFTSRAYELLVREILSVI 188

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