Conserved Protein Domain Family
GTPBP_II

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cd03694: GTPBP_II (this model, PSSM-Id:58085 is obsolete and has been replaced by 293895)
Domain II of the GP-1 family of GTPase. This group includes proteins similar to GTPBP1 and GTPBP2. GTPB1 is structurally, related to elongation factor 1 alpha, a key component of protein biosynthesis machinery. Immunohistochemical analyses on mouse tissues revealed that GTPBP1 is expressed in some neurons and smooth muscle cells of various organs as well as macrophages. Immunofluorescence analyses revealed that GTPBP1 is localized exclusively in cytoplasm and shows a diffuse granular network forming a gradient from the nucleus to the periphery of the cells in smooth muscle cell lines and macrophages. No significant difference was observed in the immune response to protein antigen between mutant mice and wild-type mice, suggesting normal function of antigen-presenting cells of the mutant mice. The absence of an eminent phenotype in GTPBP1-deficient mice may be due to functional compensation by GTPBP2, which is similar to GTPBP1 in structure and tissue distribution.
Statistics
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PSSM-Id: 58085
View PSSM: cd03694
Aligned: 29 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 23-Aug-2004
Updated: 5-Sep-2006
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAB90495  388 FLMYIDKIYSVt--GVGTVVSGSVKSGELAEGDEVYIGPfqdGSFRRVRIQSIEMHhYRIDRAKAGDIIGAAVKgvr--- 462 Archaeoglobus fulg...
EAA04814  351 IEFQIDEIFRVa--EVGTVAGGLLCKGVLTENSQVKVGPlqdGSFFSVTVQTIHRNkALFCLYTSQHYSKNSVLfcsp-- 426 Anopheles gambiae ...
XP_419499 405 TEFQVDEIYTVp--EVGTVVGGTLSSGICREGEHLVVGPtddGKFLRLKVCSIQRNrSACRVLRAGQAATLALGpfd--- 479 chicken
AAK93508  450 CEFQVDEIFRVs--DVGPVVGGLLVQGVLTENMAMKIGPlpdGSFHPVTVNTIHRNkAPCRVVRAGQSASLSFSmdqd-- 525 fruit fly
XP_394725 400 CLFQIDETFRVa-gLNEPVLGGLLVKGAIALGTRLLVGPlpdGEFSPVKVVSLHRNkAPCCLVRASQSASLTLApstnrs 478 honey bee
XP_972902 376 PEFQIDENFKAg--DVGQIIGGLLTKGVITEGMQMQIGPqkdGSFLNVVIKSIHRNrVPCRMVRAGQSAALCLSsyi--- 450 red flour beetle
CAK11377  408 TEFQVDEIYSVp--DVGTVVGGTLYSGVCREGDRLVVGPtddGKFLRLKVCSIHRNrSGCRVLRAGQAATLALGnfd--- 482 zebrafish
AAF78884  369 TEFQVDEIYTVp--EVGTVVGGTLSSGICREGDQLVVGPtddGCFLELRVCSIQRNrSACRVLRAGQAATLALGdfd--- 443 human
XP_787032 381 TEYQVDEVYSVp--NVGRVVGGTLYRGVIKEDDTLLLGPseeGTFSKVNIQSIHRNrSASRVVRAGQAATLALGeme--- 455 purple urchin
AAX24879   79 TLFWINQVYTQipgVCNPVIDGRVQLGQLLNNQILWLGPdqfGDFYPVQIVSLMHNlQVHDIAYAGQSASMEVYf----- 153 Schistosoma japonicum
AAB90495  463 --ydeLRRGMVISR 474 Archaeoglobus fulgidus DSM 4304
EAA04814  427 -mdivLAQVSVLFH 439 Anopheles gambiae str. PEST
XP_419499 480 --rslLRKGMVMVS 491 chicken
AAK93508  526 --vptLRSGMVLLG 537 fruit fly
XP_394725 479 pplphLRPGMVLIS 492 honey bee
XP_972902 451 ---pnLRNGLVLLR 461 red flour beetle
CAK11377  483 --rslLRKGMVMVS 494 zebrafish
AAF78884  444 --ralLRKGMVMVS 455 human
XP_787032 456 ---kpIRKGMVLVS 466 purple urchin
AAX24879  154 -----LPKTWNTMT 162 Schistosoma japonicum
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