6J9R


Conserved Protein Domain Family
CC_brat-like
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cd20482: CC_brat-like 
coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
This family contains the coiled-coil (CC) region of Drosophila brain tumor (Brat), a translational repressor that belongs to the tripartite motif (TRIM) protein superfamily. TRIM proteins play important roles in various cellular processes and are involved in many diseases which consists of two B-box domains and a coiled-coil (CC) domain at the N-terminal region, and an NHL domain at the C-terminus. Brat localizes at the basal cortex during asymmetric division of Drosophila neuroblasts by directly interacting with the scaffolding protein Miranda (Mira), which it does through the CC-NHL domain tandem, indicating that the function of the Brat CC domain is to assemble Brat-NHL in dimeric form which is necessary for Mira binding. Brat CC forms an elongated antiparallel dimer similar to its other TRIM protein counterparts, but the overall length of Brat CC dimer is shorter than the TRIMs.
Links
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Statistics
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PSSM-Id: 467844
Aligned: 63 rows
Threshold Bit Score: 111.474
Created: 27-Apr-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
homodimer
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:6J9R: Drosophila melanogaster brain tumor protein forms a homodimer; contacts at 4.0A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  ## ###  #  #                        ##  #  ##  ##  #      ##  #  ##  ##  
6J9R_B          5 NESALQTLLADXRGKIGEIVgia-----------gnsDQNLTKVKLQYQKAHNELNETHQFFASXLDERKTELLKELETL 73   Drosophila me...
XP_029644255  226 HKAGLQRLISGARAQIPGIQksv-----------kevEEVSEKLNLKLREAEDEIVSAFDVLDKLIVQQKTTLLKELSEI 294  Octopus sinensis
XP_002735026  148 HKKELEELLTKAKARIAPLThai-----------dlvSNTREKLSAKKTNAETDLVKSFETLDKVITTRKETLLNQLETY 216  Saccoglossus ...
XP_013393215  231 HQSALRNLIHNAQARIPVIEdai-----------tvvSSVSTALCDKFKEAEMQISDAFDALNELIDQRRNKLLSDLEST 299  Lingula anatina
ELU03406      155 HREMLGELLKKAHLQIPAVReal-----------eevNMVSETLGKNYKDAEGMIQESFDALSRLLLQRKDVLLSDLQSK 223  Capitella teleta
XP_002735871  205 QRPILEKLLHHAQEKIPTLEgal-----------dnvKFVLQQLDSEKEAAEERIREQKRSLVSTIEQKEQTLLQDLEDT 273  Saccoglossus ...
XP_002166121  193 HRNGVTNLLDNAKRKIPVIKlal-----------keiAEVKENLNQRRTSIAHFIKSKIDLLIKYMEERKTQLLSQLDEI 261  Hydra vulgaris
XP_021962521  141 EKLRLQQLLDGITEKVKKLEdav-----------qlaETAAEELASNKVVGEAQISAAFDQLVTRLKERRSNLLDELDLQ 209  Folsomia candida
XP_027208033  391 HRAAMHQLIDRVTMQLPCVKeai-----------cdiQDVCHNLEERRADAENEIRRCFNTLHELLDKRQTALINLLNSI 459  Penaeus vannamei
XP_035674560  451 KYSQMKDIVSKTKMVIDTFLrstndqirafetamsvvAEVEKDKKKQREDAEREIMERVELFTKSILDYKDGLLSDLDMM 530  Branchiostoma...

Feature 1         #         ##  #   #  ##  ## ##         #  ##  #  ##    
6J9R_B         74 YTAKVNSNNSWQQRSRDLIDKGLATCEAVERspappSSLLTEALLLRKSLEQQLQ 128  Drosophila melanogaster American nodav...
XP_029644255  295 HTSKQMVLNKQKDTLESTLSRISNCCEVTEEal--tHGKETAILVVKKEVTEKLQ 347  Octopus sinensis
XP_002735026  217 HSSKLKVLEEQKKKLELGLSNIINSCEFTEQal--tHGNETEVLLVKKQMADRLR 269  Saccoglossus kowalevskii
XP_013393215  300 HKVKQATLHSQKQTLLDILTNINDCCQLTEKal--tHGSETDILLMRKEMTAKLS 352  Lingula anatina
ELU03406      224 YSDKQRTLQEQCESLEATLNGINSCCEFTQNal--kHGNETEVLLVRKEMTEKLS 276  Capitella teleta
XP_002735871  274 YNGKKKILEAQQDGLMLGLGNVNSGCEFTENll--kYGNELALLAVKKQALQRMQ 326  Saccoglossus kowalevskii
XP_002166121  262 YLEKESVINDQQDELELDLDNFHSSCEFVENmm--nYGNEAEVMTVKRFMTKRLR 314  Hydra vulgaris
XP_021962521  210 YNVKLDLIHKSRTVLRNHLKDVQECCLLTEKal--sHENETEILFVKKQIGERLE 262  Folsomia candida
XP_027208033  460 ESEKQQTLGNQREELEAWVGGVESGCEFVEKal--tHCPAMEVVLVRKQLGERLM 512  Penaeus vannamei
XP_035674560  531 FTQERVELSTEREKLEFQVAKLKSSCEFTEKll--kYGTQTEVVDYQEHVTNRLN 583  Branchiostoma floridae

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