Conserved Protein Domain Family
TFP_LU_ECD_Babo
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cd23598: TFP_LU_ECD_Babo 
extracellular domain (ECD) found in Drosophila melanogaster Baboon and similar proteins
Baboon (Babo) is the Drosophila transforming growth factor-beta (TGF-beta)/activin-specific type I receptor that transmits signals through dSmad2. Baboon/dSmad2-mediated TGF-beta signaling is required during late larval stage for development of adult-specific neurons. In addition to dSmad2, it can Mad and bone morphogenetic protein (BMP)-specific R-Smad. Baboon is the ortholog of the human activin receptor-like kinase (ALK)-4/5/7. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467127
Aligned: 40 rows
Threshold Bit Score: 79.313
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_477000    127 IKCHCDt-------------------CKe-------------sNNICET--DGFCFTSVeknsdGSIIFSYSCMVVkynm 172 fruit fly
AEU03849      25 LQCACDr-------------------CEk-------------tNFTCET--DGVCFKQLil--eSSVTMTMRCMDAdrlt 68  Florida lancelet
TRY61003      24 LDCICGkvvlddttfppittvstedsCPvnatssh-iqvegvnLAICST--DGRCFKSIhn-sgGRIETNYICVKEnmlq 99  Tigriopus calif...
XP_023332900  24 LICSCNnl----------------smCA---------------ESTCQT--DGKCFRSLky-dnGVIRERLQCLTKeqlv 69  Eurytemora affinis
XP_023329711  21 LRCLCGvsetpitdpl-atptvikdsCEepsleeggclehgacYGVCST--DGYCFKSIsr-kdNFIRRTYRCLDQhmlt 96  Eurytemora affinis
QBA83600      26 LKCKCSkg----------------reCGk-------------nSTTCTT--EGVCFALTyi-kkSLVTTNYGCFHPevll 73  medicinal leech
XP_022690036 185 LRCYCNd-------------------CTt-------------sNYTCET--NGVCFAGTkrvdgDKYEFYYSCVGQeelq 230 Varroa jacobsoni
XP_018494391 147 RRCYCNn-------------------CGs--------------EQVCET--DGVCFAGSerkenGQLEYFYRCLDAkrmf 191 western predato...
XP_022690033 185 LRCYCNd-------------------CTt-------------sNYTCET--NGVCFAGTkrvdgDKYEFYYRCLDKprmf 230 Varroa jacobsoni
AEW90635      34 LKCNCNyga---------------vsCK---------------NNICTTdnEGKCYFRIyr-lmQKEERELGCLDKadmv 82  Helobdella sp. ...

NP_477000    173 -qrskPFECLTsner---------------------------fdtyRIDCC-KSDFCNKN 203 fruit fly
AEU03849      69 -ppenPFICQDsnn-----------------------------prfAIRCCkTHDFCNRE 98  Florida lancelet
TRY61003     100 -pkerPFFCHFsekn---------------------------krefQSQCCyETDFCNAN 131 Tigriopus californicus
XP_023332900  70 -pifrPLICEYskkt---------------------------tqvyISGCCdDYDLCNLS 101 Eurytemora affinis
XP_023329711  97 -pehrPLYCYAradi---------------------------tdryRVGCCkTGELCNSN 128 Eurytemora affinis
QBA83600      74 -pagnPMICYDneqk---------------------------tffeKRKCCwSKDYCNAE 105 medicinal leech
XP_022690036 231 -pprkPLICETaetpn--------------------------kqfvKVECC-TTDMCNQN 262 Varroa jacobsoni
XP_018494391 192 phegfAVQCNRthpdteydir----------------gyrrgiveeATWCCdSEDFCNKN 235 western predatory mite
XP_022690033 231 pgedyISQCNRtstanqfdtrlsstpahsirgqlklghkhdfvpeeSNWCCdSEEMCNRK 290 Varroa jacobsoni
AEW90635      83 -pqgnPFQCHSsiva---------------------------ahkeVRNCC-STDFCNGK 113 Helobdella sp. Austin
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