6SF1,4FAO,2LCR


Conserved Protein Domain Family
TFP_LU_ECD_ALK1
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cd23534: TFP_LU_ECD_ALK1 
extracellular domain (ECD) found in activin receptor-like kinase 1 (ALK-1) and similar proteins
ALK-1 ((EC 2.7.11.30), also called ACVRL1, or ACVRLK1, or serine/threonine-protein kinase receptor R3 (SKR3), or TGF-B superfamily receptor type I (TSR-I)) acts as type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, it forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ALK-1 may bind activin as well. This model corresponds to the extracellular domain (ECD) of ALK-1, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467064
Aligned: 36 rows
Threshold Bit Score: 67.7649
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
BMP10
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:BMP10 interaction site [polypeptide binding site]
Evidence:
  • Structure:6SF1; Homo sapiens ACVRL1 in complex with BMP10, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #                ####       #   ####  ##       ## #           
6SF1_A         9 GPLVTCTCESp-HCKGp-TCRGAWCTVVLVREEgrh-pqEHRGCGNLHr-ELCRGrpteFVNHYCCDSHLCNHN 78  human
4FAO_C        10 GPLVTCTCESp-HCKGp-TCRGAWCTVVLVREEgrh-pqEHRGCGNLHr-ELCRGrpteFVNHYCCDSHLCNHN 79  human
P37023        29 GPLVTCTCESp-HCKGp-TCRGAWCTVVLVREEgrh-pqEHRGCGNLHr-ELCRGrpteFVNHYCCDSHLCNHN 98  human
2LCR_A        12 GPLVTCTCESp-HCKGp-TCRGAWCTVVLVREEgrh-pqEHRGCGNLHr-ELCRGrpteFVNHYCCDSHLCNHN 81  human
XP_023361071   5 NSLLTCACENf-NCKGssTCQGSWCTVWLIKEAggq-prEYRGCSNQHhqETCLGlpteAFAHHCCYQPLCNLN 76  Tasmanian devil
OCT92734      33 SKYWTCVCNDp-SCSGe-TCVGRVCYVAESYLTesevifTVKGCYNNSikERCNSkm-kNLIEFCCESDFCNKD 103 African clawed frog
PIO40982      20 ITSYNCTCEGg-HCSEn-TCNGKTCFVTEQLLEnne-irRVRGCFNSDitEQCNSkt-sFSEARCCYSNFCNAD 89  American bullfrog
PKK19257      22 ADELLCACDVp-HCSLp-TCTGTVCFVSKRKEEgt--itQHRGCFSQNilEHCRAtateQYGTRCCESSMCNAE 91  rock pigeon
RXM94219     293 KGRWECVCEGseGCEDg-RCWGHRCFVVVSAEGy-----TVKGCYTTHimERCRQp---PQREKCCEGTFCNTN 357 sterlet
XP_029450387  22 NDLWQCICDGp-GCTQd-TCRGRKCFVTIENADgf--tkQTKGCFSEHlmEQCKStvqgTATTKCCDADMCNGN 91  two-lined caecilian

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