Conserved Protein Domain Family
USP47_C
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pfam19718: USP47_C (this model, PSSM-Id:466158 is obsolete and has been replaced by 466158)
Ubiquitin carboxyl-terminal hydrolase 47 C-terminal
This is the C-terminal domain of Ubiquitin carboxyl-terminal hydrolase 47 (USP47), a ubiquitin-specific protease involved in deubiquitinating of monoubiquitinated DNA polymerase beta (Polbeta), being required for its stability and, therefore, plays a role in DNA base excision repair (BER). The C-terminal domains in USPs mediate protein- protein interactions.
Links
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Statistics
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PSSM-Id: 466158
Aligned: 9 rows
Threshold Bit Score: 337.111
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_019850016 1225 RIKVFLLHINNTEFFNLMMESIVAKNTPVREFKKQIIEEAKVQgIDCVLELDKMRLRKKTWRSPGTVYLDHQLI-----D 1299
2_pfamImport    1 RIKLYLLQVNKIRFCKFMMESIVAMDTPVREFKKQIIEEAKKQgIDCVLELDKMRLREKNRLSPGTVYPDHERIynarsP 80  
4_pfamImport    1 RIKLYLLQVNNTDFCKYMMESIVAKGTPVREFKKQIIEEAKVQgIDCVLELDKMRLRYKRGVYPRAVYLDDQMI-----D 75  
3_pfamImport    1 RVKLYLLQVNNTEFCTFMMESIVAKGTPVREFKKQIIEEAKVQgIDCVLELDKMRLRYKKGVYPDTVYLDHQVI-----D 75  
EGI63559     1127 KVKLYQLLIDSTEPYKFLCEWIVSRDMTVGHAKKEILAEIKRK-YDIDIPYEKCRLRKKYYKTASKVFLNEQKF-----E 1200
ESP03989      418 RVKVYQLLVNQPEPCKYLVETIFAKGMSVVESKKLTLPEIKEQ-VSLDIPLSRCRFRKKTWKNPGVVYLDSQIY-----D 491 
RUS84034     1416 RVKVFQLCVNEAEVCKYLVESIFAKGMTVLESKQILLDEIQAQ-CGMDVPLDRCRLRKKSWTNPCTVYLDKQVY-----D 1489
XP_019857767  511 iFKLYLLQLNNTYFCKYMMESIYAKGTPVREFKKQIIEEAKVQgIDCVLELDKMRLRKKSEVYPGRVYLD---------- 580  Amphimedon qu...
XP_019861197    1 -----------------MMESIVAEGTPVKEFKKQIIEEAKVQgIDCVLELDKMRLRYKREVYTSMVHLDHQVI------ 57   Amphimedon qu...

XP_019850016 1300 kDIHVYAG--SEMYVEPLKEPEKMKLPTQMQVYVRRWRPSEYSVDPTEEVILDT-A--SPLDLKKKLSELSEVPVDAISV 1374
2_pfamImport   81 rIDDINKE--IHVYVEPLKGPEKKKHTGQRQLYVIRWRPSQCSVDPIEEIILDSlF--NPKHVIEKLSELSGVPAKYIYY 156 
4_pfamImport   76 -----ATK--ETHYVEPLKGPEKKKHKGQMQVYVIRWHPSQCSVDPIEEIILDN-N--DPKHVIEKLSELSGVPTEYIYC 145 
3_pfamImport   76 ------TS--MGMYVEPLKGPEKKKHDRQSQVYVIRWHPSQCSVDPIEEIILDNrY--DPKDFIGKLSELSGVPAKYI-Y 144 
EGI63559     1201 -DLQFHSQ--FEMIVQELSDKEIVTDTNQIVLFVRRWLPAKLQLGQFQEIVMDN-R--TVEELKKKLSSISDIPEEHIDI 1274
ESP03989      492 dDIAIFPN--WEVFLEVLDGPETKTVATQLAVYVRRWRSSTYTFEPFQEVVLRQ-E--TLEELKTKISEISSIPVDNIDY 566 
RUS84034     1490 tDIVLYPN--WEIFLEVLDGPEKFVKSDQLAVYVRHWHPSTHVIDRFQELVLSH-R--TLQELKAKISSSSGIPVEHVEI 1564
XP_019857767  581 --HQTIDTikETYYVEPLKGPEKMKHHTQRQVYVIRWHPSHFYVDPIEEIILDK-DnnDPKHVIEKLSELSGVPAEYIYF 657  Amphimedon qu...
XP_019861197   58 -----GVS--RDIYVEPLKGPEKIKHQKQIQVYVIRWHPSQCSVDPIEEIILDNnN--GLKHVIEKLSELSGVPAEYIYC 128  Amphimedon qu...

XP_019850016 1375 AKGVgSFPAEISCLDIENELEWNPAIQSISqTPFSLYDDGGVIYYKDNREKMKEITAEERAEIEKTEnkrvnSVGVYGTG 1454
2_pfamImport  157 TEGE-SFSVEISCLDIEYKLRWYSITNLYR-YSLGLYYEGRVIYYKDKRERMKKLTDKERSEIQEAE-----EARLNRIK 229 
4_pfamImport  146 AKSE-PFPVELSCLDIENKLQWYSITSHRL-YSLELYGDGDVIYYKDNRETMKELTDKERSEIHKAE-----EARMKKIS 218 
3_pfamImport  145 RTGSrLFPVEISCLDIENKLEWYSVTS--GrYPLGLYGDGHVTYYKDNRETMKELTDEERSEIQEAE-----EA------ 211 
EGI63559     1275 AKGKgSFPCDNSVLRIQNEHDWNEHHDSLS----YNFEDGAVFLYRDNKEKPKQLNADEVMEIAFKE-----NSRLTPLS 1345
ESP03989      567 GKGKgTFPCELSVLEVDTEVDWNPPCVKLS--QLYICDDGHVIYYKDRTEQPGELTEEQKKEMQQKE-----NIRIAKYS 639 
RUS84034     1565 AKAKgTFPCEVSVLEVQSDLEWNPHAFNLKdWPLNICEDGSIVFFRDAREELVELSEEKKKEIQQKE-----NR-ISHQA 1638
XP_019857767  658 AKSE-SFPVEMSCLNIENKLKWYSITSDTYs-KL--YSDGRVIYYKDNRETMKKLTYKERSEIQEAE-----EARLQKI- 727  Amphimedon qu...
XP_019861197  129 AKSQ-SFPVEMSYLDIENELKWCSITSDSSsLRL--YNDGYVIYYKDNRETMKELTDKERSEIQDAE-----EARLKKI- 199  Amphimedon qu...

XP_019850016 1455 SSSSSghssysyYRKERALKIY 1476
2_pfamImport  230 EIKAL-------YSIDKDIDYD 244 
4_pfamImport  219 ECMYQ---------------HW 225 
3_pfamImport  212 -RLRR--------IRECRLKHW 224 
EGI63559     1346 TTSSYs------PRRERALKIY 1361
ESP03989      640 PKMLTy-----sPRKEKALKIY 656 
RUS84034     1639 HRSSFs------PRKERALKIY 1654
XP_019857767  728 REYKY---------QYGTYCLD 740  Amphimedon queenslandica
XP_019861197  200 RECMY---------QPLALIGL 212  Amphimedon queenslandica
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