Conserved Protein Domain Family
AGK_C

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pfam19712: AGK_C (this model, PSSM-Id:466156 is obsolete and has been replaced by 466156)
Acylglycerol kinase C-terminal
This domain corresponds to the C-terminal of mitochondrial Acylglycerol kinase (AGK, also known as MuLK). AGK is a metazoan-specific protein integrated into the mitochondrial inner membrane through a short N-terminal transmembrane domain. This large C-terminal domain is adjacent the kinase domain and it is oriented to the intermembrane space. AGK is a subunit of the human TIM22 complex which stabilizes the complex and regulates the import and assembly of mitochondrial carrier proteins, a function independent of its kinase activity. Disturbances in both functions of AGK (phospholipid metabolism and mitochondrial protein biogenesis) contribute to the pathogenesis of Sengers syndrome.
Statistics
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PSSM-Id: 466156
Aligned: 19 rows
Threshold Bit Score: 303.151
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003220903 209 VTGLRWGSYRDAGAKVSKYWYLGPLKIQAAHFFNTLKEWPQKHLASLSYLGPTPRPPEEPEKKTSRPPLYARIYKRLLHY 288
XP_006633764 209 LTGLRWGAYRDVTANVSKYWYLGPLKTKAAHLFSTLKEWPQSHEATLTYQGPTPRPPEESTDTPVRPPLLTRIFSRLALY 288
KPP76135     209 LIGLRWGSFRDVATSFSKYWYLGPLKTKAAHWFSTLREWPQNRQASLSFQMPTPRPPDEPTERPPRPWLLRRIIHRLQHF 288
ACI32974     209 LIGLRWGAFRDVAATIKKYWYLGPLKTKAAHWFSTLREWPQVREASVSYLAPTLRPPDLPEQKPQRPHLMYRIAHRLKNY 288
3_pfamImport   1 LIGLRWGAFRDVAAKISKYWYLGPLKTNAAHWFHTLREWPLVHDVSVSLLAPRPRPPDLDPQKPPRPNLLHRIIRRLKNY 80 
4_pfamImport   1 LLGLRWGAFRDAAATISKYWYLGPLKKSAAHWFSTLREWPLVRNVSVSYLAPTLRPPDSPCEKPPRPNLLSRIACRLKNY 80 
XP_004069900 209 LMGLRWGAFRDVAATISKYWYLGPLKTNAAHWFQTLKEWPLVRQLSISYLAPSLRPPDLPPQKPPRPNLLRRIVRRLKSY 288
OCT86100     159 VQGIRWGSYRDASVKVSKYWYLGPLKARAAHLFSALKEWPQQHQASISYLGPAERPPEEPEQKPSRPPLYVRIYRRLALY 238
XP_011605303 153 LMGLQWGAFRDAASKISKYWYLGPLKTYAAHWFSTLREWPLVRDISISHLAPTLRPPDQPFEKPPRPSLLYRIARRLKNY 232 torafugu
XP_008310056 209 LMGLRWGAFRDVAAKLSKYWYLGPMKTNAAHWFSTLREWPLVRDISVSCLAPNLRPPDLPLQKPPRPNVLYHIMRRLKNY 288 tongue sole
XP_003220903 289 WA-----PAPTETPKEV------------------------------------------TPEPWQEMQLSAIELSVTTQN 321
XP_006633764 289 WA-----PPKEELPQEE------------------------------------------EPEPWEKMDVSAVELSISTQN 321
KPP76135     289 WN-----PPVEGEVSSAkdnlctwspcetkmgyglvsvaavgadrppvflipltecpqeEPEHWEQKEISTVELSIMTQN 363
ACI32974     289 WY-----PPIPEPPKVE------------------------------------------EPERWNERMLSTLELSIHTQN 321
3_pfamImport  81 WS-----PPAEEPLKPE------------------------------------------EPEKWEEQQLSTAELYIQTHN 113
4_pfamImport  81 WN-----PPIEGSDDHS------------------------------------------DNANLTA-------------- 99 
XP_004069900 289 WN-----PPVKEPPKVE------------------------------------------VAEKWEEQQLATVELYVQTHN 321
OCT86100     239 WS-----PPKVEVPVEP------------------------------------------TPEPWEEAQLSAVELSITTQN 271
XP_011605303 233 WNppieePPKLEEPEQ-----------------------------------------------WKEEKLSTLELLVQTHN 265 torafugu
XP_008310056 289 WS-----PPVEEPPKVE------------------------------------------EPEKWEEKQLSTLELFVQTHN 321 tongue sole
XP_003220903 322 RHLDLKHTEDFMNICIEPDTVSKGDYIKRGSQKMEEPHMCPEGSQFLQASRCILQLPEDSEGslSIDSEEYEAMPLEVKL 401
XP_006633764 322 KNPDLRRTEDALVVCVEPDTLSKGEFISTGSTKMKDPSTCSQSGVQLLASRCQLSLPEEGAGfySIDNEEYEALPVEVML 401
KPP76135     364 RNPAVKRPEDSMVVCMEPDSLTVGEFIAIGSEKVKDPAQCSVKGQQLEASVCQLGLPQG-GGffNIDNEEYEAMPVEVRL 442
ACI32974     322 KNPVQTRTDDSLLVCVEPDSFSVGEFITVGEKKMEDATAFTRKSLKLEASACQLNLPEEGAGfyNIDNEEYEAMSVEVTL 401
3_pfamImport 114 KNPAER-VRRKLLQCFQS---------FLLNKKVKDPTLFTENSTKLEASVCRLTLPEGAAGfyNIDNEEYEAMPVEVRL 183
4_pfamImport 100 -NTSSERINDSLMICAEPDNSTVGDFITVG--------------------------LVGAGGfyDIDNEEYEAMPVEVRL 152
XP_004069900 322 KNPVERRLHDSMVIRAEPDSFTVGEFISVGSKKEADPTAFTQNSTKLEAGACQLKLPEGVSGffNIDNEEYEAMPVEVRL 401
OCT86100     272 HQPDLLRTLDSMSIHIEPDTIPKGKFIQLGAQKMTDPLLHPEDSQVLLASRCSLHLPQGTEGhfSIDSEEYEAMSVDVTL 351
XP_011605303 266 NNPverRINDSLVIHAEPDNFSVADFITVGNAKTKDPIIFSKNSTILEASACRLQLPEGAGGfyNIDNEEYEAMPVEVRL 345 torafugu
XP_008310056 322 KNPVERRINDSLVVCAEPGDFTVGEFITVGNDKVEDPSVFTKNSTQFEASACRLQLPENSGGffNIDNEEYEAMPVEIRL 401 tongue sole
XP_003220903 402 LPRKLKFFCDASKKDQMLHSTS 423
XP_006633764 402 LPRKLQFFCSPASKKEMLKDPQ 423
KPP76135     443 LPRKLRFFCSAERRQELLTHAH 464
ACI32974     402 LPRKLHFFCSAERREQLLTQVQ 423
3_pfamImport 184 LPRKLRFFISAERREELISQPQ 205
4_pfamImport 153 LPRKLRFFISAERRQQLLSQMQ 174
XP_004069900 402 LPRKLRFFISAERREQLLSQPQ 423
OCT86100     352 LPRKLHFLCHPTRKQELLQSPT 373
XP_011605303 346 LPRKLRFFISAERRAQFLSLTQ 367 torafugu
XP_008310056 402 LPRKLRFFITAERRQQLQSLMQ 423 tongue sole
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