Conserved Protein Domain Family
RhoGAP_pG1_pG2
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pfam19518: RhoGAP_pG1_pG2 (this model, PSSM-Id:466111 is obsolete and has been replaced by 466111)
p190RhoGAP, pG1 and pG2 domains
The p190RhoGAP (GTPase-activating protein) proteins, p190RhoGAP-A (ARHGAP35) and p190RhoGAP-B (ARHGAP5)4-6, regulates Rho GTP hydrolysis and are important for proper Rho signalling. They share a domain organization containing a GTP-binding GTPase domain, four FF domains, two GTPase-like folds (pG1 and pG2) in the middle domain and a C-terminal GAP domain. This entry represents pG1 and pG2 which are important for GAP activity toward RhoA and were classified as pseudoGTPases as they lack nucleotide-binding activity. Crystal structures revealed a small GTPase fold in both cases with a central 6-stranded beta-sheet surrounded by four alpha-helices.
Links
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Statistics
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PSSM-Id: 466111
Aligned: 22 rows
Threshold Bit Score: 837.059
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KPP63446      558 ICPSSPFCMDSKIEQILASRFPTRYPFfDCKAQSG-EVKADRINLVILGKDGLARELANEVR------AL---------- 620 
7_pfamImport    1 TCLSGQNCMDIQIQQNLANHASQCTNR-SRSTYMSdSVNTDKLNIVLLGCDGLAHELANEIM------AQ---------- 63  
XP_012824567  557 TCLSGQSCMDIKVEQVLANSLLQSNLG-RMNLYQD-STNLDRINLLILGKDGLAQEMTNEIR------TQ---------- 618 
EMP30765      556 TCLSGQNCMDIKVEQLLANSLLQLDHG-RLNLYHD-RANIDKVNLFILGKDGLAQELANEIR------TQ---------- 617 
OWK50068      558 TCPGCAACVDARVEQLLASRFARPAER----QRRA-DADADRINLVILGKDGLARELANEIR------AL---------- 616 
XP_025000235  558 TCPSCPLCVDSRVEQLLGSRAARPAER-NQKNFLS-DPNVDRINLVILGKDGLARELANEIR------AL---------- 619  chicken
XP_020954842  556 tcLSGQNCTDIKVEQLLTSSLLQVDHG-RLRLYHD-STNIDKVNLFILGKDGLAQELANEIRtqstddEY---------- 623  pig
XP_020954843  556 TCLSGQNCTDIKVEQLLTSSLLQVDHG-RLRLYHD-STNIDKVNLFILGKDGLAQELANEIR------TQstddeytldg 627  pig
XP_006632356  556 TCLSGQSCVDIKVEQILANRLVQLDHG-RPSLYHN-SANIDKVNLYLLGRDGLAQELANEIR------AQ---------- 617  spotted gar
XP_020390974  557 TCPNSQKCMDSKVEQLLAARFYRFSDRsLVNSHSH--SSADKLNLVLLGKDGLAHELANEIR------AL---------- 618  whale shark

KPP63446      621 --------CTNDDRYMLDGKMYELVLRPIEGNVRLPVNSFHTATFNPHGCLCLYNSKESLSYVVESIEKLRDSTLSRRD- 691 
7_pfamImport   64 --------ST-DNEYALDGKMYELELRPIEENARLSANPFQTSSAKPHGCFCVFNSIETLQYIEENLDSSTGFHYSDKR- 133 
XP_012824567  619 --------ST-DDEFALDGKIYELDLKTVDANSPYLLSQLRTSGFKPHGCFCVFSSIESLNFIGDCIGKIRCEAQIRRE- 688 
EMP30765      618 --------ST-DDEYALDGKIYELDLRPVDAKSPYLLSQLWTSAFKPHGFFCVFNSIESLNFIGECIGKIRAEASQIRRd 688 
OWK50068      617 --------CADDDKYVIEGKVYELALRPIEGNVRLPVNAFQTPTFQPHGCLCLYNSKESLSYVVESVEKSRESGAGRRDg 688 
XP_025000235  620 --------CTNDDKYVIEGKMYELSLRPIEGNVRLPVNAFQTPTFQPHGCLCLYNSKESLSYVVESIEKSAA---GRRE- 687  chicken
XP_020954842  624 --------TL-DGKIyeldlr------pvdakSPYFLSQLWTAAFKPHGCFCVFNSIESLNFIG---------------- 672  pig
XP_020954843  628 kiyeldlrPV-DAK------------------SPYFLSQLWTAAFKPHGCFCVFNSIESLNFIG---------------- 672  pig
XP_006632356  618 --------ST-DDEYTLDGKIYELELKPIDVNSALLLSHFLTPAFKPHGYFCVFNSIESLNFIGDCIGRIRAEASQIRKd 688  spotted gar
XP_020390974  619 --------CT-DDKYVLEGKMYELSLRPIEGNVKHRVNSFQTSTFQPHGCLCLYNSKESLYYIKESLEKLKESTLDRRD- 688  whale shark

KPP63446      692 NSLSHLPLSLLLVTKRGvgs--------------------------isDIGGETAQSLIAQGQQVAGKLQCIFLDPASPG 745 
7_pfamImport  134 DKTSHLPIALILAHETW------------------------------------VLATLRLQGKHIANKMQCHFVDVP--S 175 
XP_012824567  689 KDIASLPFALILANQRD--------------------------------STSKNLPILRHQGQQLANKLQCPFVDIP--A 734 
EMP30765      689 KYMASLPFTLILANQRD--------------------------------SISKNLPILRHQGQQLANKLQCPFVDVP--A 734 
OWK50068      689 HAAPPLPLALALVNKRGg-----------------------------gDGGGETLQSLIQQGQRIAGKLRCVFLDPASAG 739 
XP_025000235  688 NHPAHLPLTLMLVNKRG-------------------------------DAGGETLHSLVQQGQQIAGKLQCVFLDPAAAG 736  chicken
XP_020954842  673 ----------------EfigkirteasqirkdkymanlpftlilanqrdSISKNLPILRHQGQQLANKLQCPFVDVP--A 734  pig
XP_020954843  673 ----------------EfigkirteasqirkdkymanlpftlilanqrdSISKNLPILRHQGQQLANKLQCPFVDVP--A 734  pig
XP_006632356  689 RHIQPLPFILILANQRD--------------------------------SVCKNLPILRHQGQQLSNKLQCTFVDIP--S 734  spotted gar
XP_020390974  689 NHLAQLPLTLVLANKRE--------------------------------SGGETLQTLRNHGQQLANKLQCLFVDVTSHS 736  whale shark

KPP63446      746 IGCG-RNVSEKQLNQVLKCLLDSRRnlNFGNrsppLPPLPSgirdlhHQHSLEADLRIVMCLMCGDTYDVDQLLSPFLLP 824 
7_pfamImport  176 DTYPyRKFHELQIKQALRELLEAKKc-RPSV----VSPAPS------LKELPEVDLRIMMCVMCGDSFSVDLVLTPFLES 244 
XP_012824567  735 GTYP-RKFNETQIKQALRGVLESVKh-NSDI----ASPAPT------IKELSEADLRIVMCAMCGDPFSVDLILSPFLES 802 
EMP30765      735 GTYP-RKFNEAQIKQALRGVLEAVKh-NLDV----VSPVPT------IKDLSEADLRIVMCAMCGDPFSVDLILSPFLDS 802 
OWK50068      740 VGYG-RTVNEKQIGQVLKGLLDAKR--NLNA-----APAPGp-----REASDGAELRLAACLMCGDPVSADEVLLPILQA 806 
XP_025000235  737 IAYG-RSVNEKQISQVLKGLLDSKR--NLSL----VSVPSG------LKELADVELRVAMCFMCGDAAGADELLAPILQS 803  chicken
XP_020954842  735 GTYP-RKFNETQIKQALRgVLESVKh-NLDV----VSPVPT------NKDVSEADLRIVMCAMCGDPFSVDLILSPFLDS 802  pig
XP_020954843  735 GTYP-RKFNETQIKQALRgVLESVKh-NLDV----VSPVPT------NKDVSEADLRIVMCAMCGDPFSVDLILSPFLDS 802  pig
XP_006632356  735 GSFP-RKFNESQIKQALRGVLEALKh-NFDV----MSPLPS------IKDLSETDLRIVMCAMCGDPFSVDLILSPFLDS 802  spotted gar
XP_020390974  737 VGSG-RNFSELQINQALKGLLDTMKr-NLNL----VSASPS------IKDLTDAELRVVMCLMCGDLFNVDEVLLSIIQP 804  whale shark

KPP63446      825 QHCRPMSSlPSGTSVLLELAVGGQRQTIELSLLSYHSSFLLRKSRLVHGYIAVYSARRKASLETLCAFLCEVQDIIPVQL 904 
7_pfamImport  245 QFCTIGKI-GHSCTLVLEVFLGSHKRRVEIAPISYHSAM-MRRDEMVHGYILVYSAKRKASIAMLRAFLSGVPDVLPIHI 322 
XP_012824567  803 RTCSAAQP-GQINSLMLDKIIGDKRRRIQITILSYHSSIGVRKDELVHGYILVYSARRKASMGMLRAFLSEVQDTIPVQL 881 
EMP30765      803 HSCSAAQA-GQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQL 881 
OWK50068      807 QPCRPAPG-G-GAAVLLEAAVGAQRRRVELSLLSYHASFGTRKSRPAHGYIVFYAARRRASLATLRAFLADVPDVVPVQL 884 
XP_025000235  804 PLCRPAPC-G--GSVLLELCLGQQRRRVELSLLSYHAAFGVRKSRLVHGYVVFYAAKRRASLAMLRAFLCEVQDVVPVQL 880  chicken
XP_020954842  803 HSCSAAQA-GQNNSLMldkiigekrRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKAsmgmlraflsevqdtipvqL 881  pig
XP_020954843  803 HSCSAAQA-GQNNSLMldkiigekrRRIQITILSYHSSIGVRKDELVHGYILVYSAKRKAsmgmlraflsevqdtipvqL 881  pig
XP_006632356  803 HCCSAAQP-GQSNTLVLDKIIGDSRRRIQITVLSYHSSIGIRKDELVHGYILVYSAKRKSSMAMLRAFLAEVQDVIPVQM 881  spotted gar
XP_020390974  805 HFCSSLQP-GNSNSVMLELTIGAVRKSVEVSILSYHSSFNIRKNQLVHGYIVFYLARRKASLAMLRAFLSDVQDIIPIQL 883  whale shark

KPP63446      905 LAVGENQtelTDCDVTRERLIQGEELAHEIEARFNTVVCGPGgvvgGLHRIDMLQPFLKDVVEKRTIVEATHMYDNVVEA 984 
7_pfamImport  323 LAVTDTDcdfFTDEISKDLLMEGEQIASDIGAKFKTTSRFYK-------QTEMFTAYFREVYEQKLHIEESMSLWETG-- 393 
XP_012824567  882 VAVTDSQadfFENEAIKELMTEGEHIATEISAKFTALYSLSQ----YHRQTEVFTPFFCDVLEKKTSIENSYLAESTREA 957 
EMP30765      882 VAVTDSQadfFENEAIKELMTEGEHIATEITAKFTALYSLSQ----YHRQTEVFTLFFSDVLEKKNMIENSYMSDSTRES 957 
OWK50068      885 VALADGAgdaPDDEVSREQLAEGEEIAQEIEARFAALPRGRA-------GLDVFQAFFKDALEKKSAVEAAHLYDNAG-- 955 
XP_025000235  881 VALIDGSvdvLESDVSREQVAEGEEIAQEIDGKFAAVAYGQA-----QPKLDSFHAFFKEALEKKTLVEAMHMYDHAAEA 955  chicken
XP_020954842  882 VAVTDSQadffeneaIKELMTEGEHIATEITAKFTALYSLSQ----YHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRES 957  pig
XP_020954843  882 VAVTDSQadffeneaikeLMTEGEHIATEITAKFTALYSLSQ----YHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRES 957  pig
XP_006632356  882 VAITDSQadfFENEAIKELMTEGEHIATEIVAKFTALYSLSQ----YHRQTEVFTPFFSEVLEKKNSIEGMFIYDTTRDS 957  spotted gar
XP_020390974  884 VAITEGTe-vSESDVSRDQLEEGQEIAHEISGRFTAISSGQP----FQHNAEIFAKFFRDATEKKIFVEASHMYDNAAEA 958  whale shark

KPP63446      985 CTT-NEg--IHSPRCGSPSPVTAL-VDSE--DDVEPSPPYPtlrdD-----N--TSNI--FKL---PDlESSDtFSV--I 1044
7_pfamImport  394 ----DE----SLPQSA-GVELQGFnSNSQapDDSEPPPPYSpasnEkqpfpLn-MSDMfqFSVaekEF-SGGI-ATVppY 461 
XP_012824567  958 SQQcEDv-fTHSSRGN-SPAYICY-PDSE--DDTEAPPPYSpigdDvq--lLp------kCPL---DN-EGNE-YPI--H 1017
EMP30765      958 THTsEDv-fLQSPRGN-SLAYNYY-PDSE--DDTEAPPPYSpigdDvq--lLptPSDRskYRL---DL-EGNE-YPV--H 1023
OWK50068      956 ----DDa--FGSPRAASPLCNSNA-ADSE--EDAEA-PPg-----Sg---pF--REESakLCA---EP-DAGDaFAR--- 1008
XP_025000235  956 CGA--Ee-aAGSPRAASPQCNSHP-PDSE--EDAEP-SPYGfcrdDva-----lpKEHskLSV---EL-EGNDgLAF--I 1017 chicken
XP_020954842  958 THQsEDv-fLPSPRDC--FPYNNY-PDSD--DDTEAPPPYSpigdDvq--lLptPSDRsry---rldL-EGNE-YPI--H 1022 pig
XP_020954843  958 THQsEDv-fLPSPRDC--FPYNNY-PDSD--DDTEAPPPYSpigdDvq--lLptPSDRsry---rldL-EGNE-YPI--H 1022 pig
XP_006632356  958 TNTsEDv-fLQSPHGN-SPACN-YyPDSD--DDTEAPPPYSpirdDvl--lLptPSERtsKNRm--DL-EGNE-YPI--H 1024 spotted gar
XP_020390974  959 CSN-PEevfNFSPRPGSPLNNSNC-FDYD--EDIEGPPPYValqdEtsgplL--AKEQpkLLM---DL-EGNDnYSL--Y 1026 whale shark

KPP63446     1045 SEI-SSF--ESK--LNNKVPPQVRPKP-TVSFDF-RKVNLNPY--IDp-AGKR------KSLPTAMTWPQGVdggYDPSD 1108
7_pfamImport  462 GSPlCSH--EYLtdRSYKIGPPVLPKP-----VLpPRPDPELLkrME---TLRfg---gESIRKSLRQTPSE---SDPGD 525 
XP_012824567 1018 STPlNCH--DHE--RNHKVPPPIKPKPaVPKPRV-NRLDPNLVktIE--AGMGkn---pRKQALRTHLTHGEd--LDASD 1085
EMP30765     1024 STPlNCH--DHE--RNHKVPPPIKPKPlVPKANV-KKLDPNLLktIE--AGIGkn---pRKQSSRVPLAPPEd--SDQSD 1091
OWK50068     1009 --------------------PPGKPKA-PPPFEA-----ADPR---D---ARR-----------RSAAAPDA---FDPSD 1042
XP_025000235 1018 SVV-SAF--ESK--LNSKVPPPVKPKP-PVPFEL--GKGDLTY--LE--QGQR-------KSVSCGSWPPADa--FDPSD 1076 chicken
XP_020954842 1023 STP-NCH--DHE--RNHKVPPPIKPKPvVPKTNvkkldpnllkt------ieagigknprkQTSRVPLAHPEd--MDPSD 1089 pig
XP_020954843 1023 STP-NCH--DHE--RNHKVPPPIKPKPvVPKTNvkkldpnllkt------ieagigknprkQTSRVPLAHPEd--MDPSD 1089 pig
XP_006632356 1025 STP--VNthDHE--HNHKVPPPVRPKPiGPKTNV-RKLDPNLLktIE--AGMKst---kK--QMRVPLAHAEd--VEAQD 1090 spotted gar
XP_020390974 1027 STL-SSF--ERL---NNKVPPPVKPKP-MVHFDK-----LMKK--MDssEGKEpaskemPRKPSTVSWAPSDd-gSYTSD 1091 whale shark

KPP63446     1109 -YAEPMDAVCKPRpT-DEENIYSVPHDSTQG-KIITIRNANKTH--SNG--GGNGSDSE-AESSSLERRr-KLSAMGIKP 1179
7_pfamImport  526 -YADPLDAISRFR-N-LEENIYSVPQDSKQG-KIIRIRGRPVYQ----A------------------RK----------P 569 
XP_012824567 1086 nYAEPADTIHKPK-D-FINDTYAIPDDSQ-N-HSSRLRWFFTPQ----Gd-EENGIPDR-VPRGQVERR----------P 1145
EMP30765     1092 nYAEPIDTVFKHR-G-FTDDIYAVPDDSQ-N-RIIKIRNSFVIN--AQGd-EENGF-SDrISKSHGERR----------P 1153
OWK50068     1043 -YAEPMDAVAAKPrG-EEENIYSVPHDSTQG-KIITVRNINKAP--SNGg-SGNGSDSE-ADGGSLERRgrAAPANAAAA 1115
XP_025000235 1077 -YAEPLDAVLKPK-S-EEENIYSVPHDSTQG-KIITIRNINKSQ--PNGg-ANNGSDSE-ADSSSLERGg-RKLSLLAKP 1147 chicken
XP_020954842 1090 nYSEPIDTIFKQK-G-YSDEIYVVPDDSQ-NrI-IKIRNSFVNN--TQGd-EENGF-SDrTSKSHGERR----------P 1151 pig
XP_020954843 1090 nYSEPIDTIFKQK-G-YSDEIYVVPDDSQ-NrI-IKIRNSFVNN--TQGd-EENGF-SDrTSKSHGERR----------P 1151 pig
XP_006632356 1091 nYAEPADTLLKSK-GfS-DDIYAIPDDSQ-N-RIVKMRNSFGVLhgTHAd-EENGF-DR---LSKGGRR----------P 1151 spotted gar
XP_020390974 1092 -YAEPIDTLVRPR-G-DEENIYSVPHDSTQG-KIITIRNSISAK--SQSngSGNGSDSE-MDISSLERQ--RKLSSVSKP 1162 whale shark

KPP63446     1180 RLYRDRSKRL-GRFSSF-----RTSFSIGSDDELGVS--LKTK---EDEAGAQKADSSLNEe------S--EDPKKRNI- 1239
7_pfamImport  570 VPYKHRSERLkPRRTAPpellaTGSPSEGSDEEVQNFf-PSLSr--RKRKPRMSDSDLDKPs------A--DQDDRKKK- 637 
XP_012824567 1146 SKYKYMSKTLfSKSKSYr---yRRAHSDASDEEALTG--KERKr--KPKHRPSEEDPLLSPtvdswkgGi-DNPAITSD- 1216
EMP30765     1154 SKYKYKSKTLfSKAKSYy----RRTHSDASDDEAFTT--SKTKr--KGRHRGSEEDPLLSPvet-wkgGi-DNPAITSDq 1223
OWK50068     1116 RLYRARCARL-GRFAAY-----RPGLGVGSDDEAGAA--RKKDedgGGGHGGYKGDNAGAAye---aaDg-EDPRRRNI- 1182
XP_025000235 1148 ALYRTRCARL-GRFASY-----RSSFGVGSDDELGPI--RKKEe--DQSSQGYKGDNAVIPye----tAdgEDPRRRNI- 1212 chicken
XP_020954842 1152 SKYKYKSKTLfSKAKSYy----RRTHSDASDDEAFPT--SKTKr--KGRHRGSEEDPLLSPvet-wkgGi-DNPAITSDq 1221 pig
XP_020954843 1152 SKYKYKSKTLfSKAKSYy----RRTHSDASDDEAFPT--SKTKr--KGRHRGSEEDPLLSPvet-wkgGi-DNPAITSDq 1221 pig
XP_006632356 1152 SKYKHRSSILfNKMKAYh----RRAHSDASDDESGVAlqQKKKk--GRGHRGSEEDPLLSPvdp-wkgGi-DNPAITSDp 1223 spotted gar
XP_020390974 1163 LLYRDRSKRL-GRFASY-----RTSFSVGSDDELGSL--SSQKk-aEADSSLPKGDNTTNTye----tDg-DESKRGKL- 1227 whale shark

KPP63446     1240 ---LRSL-RRT--SK---------K--PRAKPRY--SISKP----IESNYFGVPL 1271
7_pfamImport  638 ----KSLlRKS--KEf--------K--PTAKYRKq-EVKKE------SVYFGLPL 669 
XP_012824567 1217 ---QEQE-ERK--TKkkatkvkedK--KKKKTKQlnPPTRRn---WESNYFGKPL 1260
EMP30765     1224 eldDKKM-KKKt-HKv--------KedKKQKKKTk-AFNPPtrrnWESNYFGMPL 1267
OWK50068     1183 ---LRSL-RRT--TK---------K--PKAKARP--SLSKAp---WESSYFGVPL 1215
XP_025000235 1213 ---LRSL-RRT--TK---------K--PKPKPRP--SLTKPm---WESSYFGVPL 1245 chicken
XP_020954842 1222 eldDKKL-KKKt-HKv--------KedKKgcihirkrklrtsihqhveigkvitl 1266 pig
XP_020954843 1222 eldDKKL-KKKt-HKv--------KedKKQKKKTk-NFNPPtrrnWESNYFGMPL 1265 pig
XP_006632356 1224 eqdDKKP-RKPrkPKp--------DksKRSKPKStkPLYPPtrrnWESNYFGVPL 1269 spotted gar
XP_020390974 1228 ---LRSL-RRPt-SR---------K--PKPKPRP--SISKSt---WESNYFGVPL 1261 whale shark
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