Conserved Protein Domain Family
CERK_C
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pfam19280: CERK_C (this model, PSSM-Id:466025 is obsolete and has been replaced by 466025)
Ceramide kinase C-terminal domain
This domain is found at the C-terminus of ceramide kinase enzymes. It is related to the beta sandwich domain of NAD kinases. Along with the N-terminal domain it catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This family contains ceramide kinase like proteins that lack the ceramide kinase activity. It also contains ore distantly related proteins this may have different functions.
Links
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Statistics
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PSSM-Id: 466025
Aligned: 16 rows
Threshold Bit Score: 363.636
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KPP69889     210 FCAMYGFGGRTLALAERHRWMPPSQRREFALIRALANLKPEDCEVSFLPLNVAPGgpQDPRRSEsvr-nlGEQDTE---- 284
XP_012884281 312 FSAMFGFGGRTLALAEKYRWMSPNQRRDFAVIKALTTLKPEDCTISFLPLNNSQD--ELQR--Q------GSPKSG---- 377
XP_002712274 320 FSAMFGFGGRTLALAEKYRWMSPSQRRDFAVIKALTKLKPEDCEISFLPFNNSWN--IQERSAQ------GSPDSD---- 387
XP_013886909 229 FSAMFGFGGWSLAHAEKKRWMSSSRRREYALVKTLAKLRSEDCQLSFLPAKKTNLc-LSGHQDQdqv-ekDDPVSE---- 302
NP_001082943 349 FSAMFGFGGRTLALAERHRWMPPSQRREFALIKTLAKLKPEDCELSFLTAKGAED--QKKAELN------GDGGDI---- 416
XP_014029114 449 FSAMFGFGGRTLALAERHQWMPPGQKREFAVIKTLANL---NVTLSITETLSSLE----EQV-L---------------- 504
XP_014428350 161 FSAMFGFGARTLALAEKHRWMPSNQRRDFAVIRTLASLKPEECELSFLPLKNSLQ--DSQETVRkk--keRPKKSD---- 232 Chinese soft-sh...
XP_016155405 226 FSAMFGFGARTLALAEKHRWMPSSQRKDFAFIKTLADLKPEECELSFLPLQILQE--DSHEDRKk----kERTEKG---- 295 Collared flycat...
XP_014844477 163 FSAMFGFGGRSLARAEKKRWMSSSRRREYAVVKTLARLRPEDCQLSFLPAKSSESs-LFGQQDQg------eDKELdtes 235 Poecilia mexicana
XP_015214474 357 FSAMFGFGGRTLALAEKHRWMPSNQRREFAVIKTLANLKPEDCELSFLPLTQSQK--VTEGKsrndstkdsppntD---- 430 spotted gar

KPP69889     285 ADSTWQTTQGLFLNISVMAIPCLCSMAPRGLAPNTS-LDNGSMALIAVGNASRSEFVKHLKRYSNLNNQFSFSFVETYTV 363
XP_012884281 378 CSDHWQTLQGQFLNVSIMAIPCLCSVAPRGLAPNTR-LNNGSMALIIARNTTRPEFIKHLKRYASVKNQFSFPFVETYTV 456
XP_002712274 388 YNEQWQTIQGQFLNVSIMAIPCLCSVAPRGLAPNTR-LNNGSMALIIARNTSRPEFIKHLKRYASMQNQFNFPFVETYTV 466
XP_013886909 303 GNESWITKQGLYLNISVMSIPCLSPHAPKGLAPNTS-LTNGSALLITVGKASRSEFIKHLKRYNSSSGQFNFPFVETHSV 381
NP_001082943 417 CEGDWQSRKGLFLNISIMAIPCLCSMAPRGLAPNTR-LNNGSMALISVGNTSRSEFIKHLKRYNSTNNQFGFSFIETHSV 495
XP_014029114 505 ----WMTNQGLFLNVSIMAIPCLCSMTPRGLAPNTRyFLPLTPSVCVCVCVCKIEQWKHGLDRSRKHFQFSFSFVETHTV 580
XP_014428350 233 NKVQWHTIQGHFLNVSIMAIPCLCSMAPRGLAPNTR-LNNGSMALIVVRNTSRTEFIKHLKRYASVKNQFNFPFVETYAV 311 Chinese soft-sh...
XP_016155405 296 SKDQWQKIQGHFLNVSIMAIPCLCSMAPRGLAPNTR-LNNGSMALIVVQNTSRSEFIKHLKRYTSEKNQFNFPFVETYTV 374 Collared flycat...
XP_014844477 236 AEESWMTNQGLYLSISVMSIPCLSPHAPQGLAPNTS-LDNGSASLIAVGNASRSEFIKHLKQYTSSSGQFSFPFVETHSV 314 Poecilia mexicana
XP_015214474 431 DEEEWQKIKGLFLNISIMAIPCLCSMAPRGLAPNTR-LDNGSMALIVVRNTSRADFIKHLKRYGSLKNQFSFSFVETYTV 509 spotted gar

KPP69889     364 QAVRLRPRSQAGWVDDNSEdnvefetKKTPFISSEGT-YPWNIDGELLEVPGELLIRVHPQLITLFGVNVEELEDCPVKC 442
XP_012884281 457 EEVKVCPKTKTSGYSESEE-------VGPHESASETS-LPWNIDGDLMEVASEVHVRLHPGLISLYGGSLEEMNDCNVTC 528
XP_002712274 467 EEVRVRPRNRTSGYNPEEE-------EGSHETASEDG-FPWNVDGDLMWVPSEVHVRLHPRLISLYGGTMEEMSDSKETC 538
XP_013886909 382 SAVKLHPFSLAGCS-EESEeeg--daKEAPTILSEGVaLPWNIDGELLEIESEVLIRVHSRLITLYGEEVDEAEST-TSC 457
NP_001082943 496 KAVRLRPSSQSSWTDDVSEeneesdsKNTPIISSEGT-YPWNIDGDLLDVPSELLIRVHPQLLTLFGSDVEEAEETPVKC 574
XP_014029114 581 RAVRLRPHSQRSWSDDVCEdngecesKNTPIISSEGT-YHWNVNGDLLEVPSELLIRIHPQLLTLFGVDIEEAEEAHIKC 659
XP_014428350 312 QEVKVQPRNKIGYDTEENV--------YLQATFTEGN-YPWNIDGDLMEGASEVHVRVHRQLINLYGGSIDELDDSKVMC 382 Chinese soft-sh...
XP_016155405 375 QEVKVQPRLKSGPDAKENV--------CLN---AEGN-YPWNIDGDLMKEASEVHVRVHPQLIDLYGVNTDDLESSQVTC 442 Collared flycat...
XP_014844477 315 SAVRIRPRSLIGWSEEESEdeg--dsKNTPIIQSERAaLPWNIDGELVEIANEVLIRVHPRLITLYGEEVNEAEST-VTC 391 Poecilia mexicana
XP_015214474 510 QAVKVRPRPWSGWGDDTLEenveidsKNTPMISSEGS-YPWNIDGDLME-ASEVCIRVHPQLITLFGVNTEEVDESTVKC 587 spotted gar

KPP69889     443 SCI 445
XP_012884281 529 NCL 531
XP_002712274 539 HCL 541
XP_013886909 458 NCF 460
NP_001082943 575 SCI 577
XP_014029114 660 SCI 662
XP_014428350 383 SCL 385 Chinese soft-shelled turtle
XP_016155405 443 NCI 445 Collared flycatcher
XP_014844477 392 SCI 394 Poecilia mexicana
XP_015214474 588 SCI 590 spotted gar
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