4UX8,7AML


Conserved Protein Domain Family
RET_CLD4
?
pfam17813: RET_CLD4 (this model, PSSM-Id:465517 is obsolete and has been replaced by 465517)
RET Cadherin like domain 4
RET is a single transmembrane-spanning receptor tyrosine kinase (RTK) that plays critical roles in the development of vertebrates. Structural analysis indicate that the ligand-binding RET ectodomain (RET-ECD) contains four consecutive cadherin-like domains (CLD1-CLD4) followed by a membrane-proximal cysteine-rich domain (CRD). This entry relates to CLD4 which is required for CRD folding.
Links
?
Statistics
?
PSSM-Id: 465517
Aligned: 25 rows
Threshold Bit Score: 113.576
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
4UX8_A        376 LPS-TYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGAN-------CS-TLGVVTSAEDTSGILFVNDTKALR 446 
3_pfamImport    1 FANvTHMFPLARRASFYAQVGRVCVENCHRFDGFRVTYRLQVPDKNasadvqsCYaAISITQAPDDMWGLLYVNDSEVLC 80  
XP_004077559  394 FANtTQEFTVSRRASVYAQVGRICVENCLEFGGFRVTYWLEVLDKNasasslsCHaAISITQAPDGMWGLLYVNDSEPLH 473 
XP_023183795  395 FANiTHVFTLSRKASIYAQVGRICVENCLEFDGFSVSYQLEVPDKNmssellsCYsAISITQAPDRMLGLLYVNNSGALS 474 
XP_022540397  394 FSNiTY-VSLSRKSTLYSQIGKVCVDNCLKFKGIDIAYEIEIADRNvsadvlsCYsAVSVARSLEEMSGVLYVNDTKPFQ 472 
AJG05962      388 FSNvTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNitaeaqsCYwAVSLAQNPNDNTGVLYVNDTKVLR 467 
KPP59675      352 FPSaTSLFTVSRQSTAFAQIGRVCVDNCLKFHGISVVYRLVPAEKNssalersCYtAVGITPSSSDISAVLYIIHTEPLQ 431 
XP_006630860  393 FTNvSFLFTVDRKAAPYTQIGTVCVDNCKKFQGIEVTYKLNI-DRNasllvktCYaAVAIEQSREDSSAILYVNRTDSLR 471 
XP_005473896  391 FPNvTHIFTVSRRASAYAQVGKICVENCQQFDGFSVIYRLEVADKNmsadsqaCYtAISITQSPNRKWGHLYVNDSEALC 470 
7AML_A        367 FSNvTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNitaeaqsCYwAVSLAQNPNDNTGVLYVNDTKVLR 446 

4UX8_A        447 RPKC-AELHYMVVATDQQTSR-QAQAQLLVTVEG 478 
3_pfamImport   81 RPEC-QDLQYLVVAEEEHTQL-EASTQIHIILDA 112 
XP_004077559  474 RPEC-QDLRYAVVAQEEFKEL-ETSTQIQVLLDG 505 
XP_023183795  475 KPGC-QDLDYTVVAQEEQTQL-VASTQIRILLHG 506 
XP_022540397  473 RQECfQDLEFVLIAKEQQRHL-EAKTQLLIRFEG 505 
AJG05962      468 RPEC-QELEYVVIAQEQQNKL-QAKTQLTVSFQG 499 
KPP59675      432 QPEC-RKLHFTLEAQEKKTQL-QAKTELVIQFNG 463 
XP_006630860  472 NKDC-QDLQYIVVAQERQNKQtQAKTQLTITLVG 504 
XP_005473896  471 KPEC-QDLQYLVVAQEGNEQL-EASTQIHIKIDG 502 
7AML_A        447 RPEC-QELEYVVIAQEQQNKL-QAKTQLTVSFQG 478
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap