6Q2J,7AML


Conserved Protein Domain Family
RET_CLD1
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pfam17756: RET_CLD1 (this model, PSSM-Id:465485 is obsolete and has been replaced by 465485)
RET Cadherin like domain 1
RET is a single transmembrane-spanning receptor tyrosine kinase (RTK) that plays critical roles in the development of vertebrates. Structural analysis indicate that RET contains four consecutive cadherin-like domains (CLD). This entry relates to the first CLD at the N-terminal. Several regions within RET-CLD1 have been shown to be important for ligand-coreceptor binding. CLD1 and CLD2 have a distinctive clamshell shape and CLD1 is essential for CLD2 folding. CLD1 contains 2 sites for GDNF receptor alpha 1 binding.
Links
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Statistics
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PSSM-Id: 465485
Aligned: 20 rows
Threshold Bit Score: 177.888
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6Q2J_E          1 LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHlygTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEK 80  
2_pfamImport    1 LYFPQNEYTETVYVGQLAGTPILQVHAMLDSDSERSHFYLCWT---NPLRRPAYSSWFNLDINTGTLSLNKTLEESDFAS 77  
XP_005473896   27 LYVPQNEYIETVYVGQQAGTPVLQVHAMQDNKSEKPHFYLCPT---KTAMPSHYGSWFYMNINTGTLFLNKTLEESDFAQ 103 
XP_022540397   26 LYFPQNLYSETIYVGQPAGAPLLQVHSMRETSSERPYFSLCWR---NVQKPPLIAAWFHIDPVSGVLYMNKTLEWTDFDS 102 
NP_858048      23 LYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSH-------RDAFTSWFHIDEASGVLYLNKTLEWSDFSS 95  
XP_006630860   24 LYFPQKKYSENVFVGQPAGTPILQLHVMLDNESETAHFCLRQLt-eYPKIKL-----FHLDERTGLLSLNRTLDWSDFAP 97  
XP_004077559   30 LYFPQKEYIETVYVGQPAGTPVLQVHAMQDSAAERPHFSLCWA------RRPYYASWFHMDVTTGVLYLNRTLEPADFSS 103 
XP_023183795   30 LYFPQKEYTETVYVGQPAGTPVLQVHAMLDGRSERPHFYLCGS------RRPPYALWFQMDVQTGELSLSKTLEETDFAS 103 
7AML_A          2 LYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSH-------RDAFTSWFHIDEASGVLYLNKTLEWSDFSS 74  
XP_016851013   20 LYFPRKDYHENVYLDQPGGSPLLQIHALKDSEKEKIYFWLCPQl-hIPGVGIKDNLWFQIKEKTGLLFLNKSLDREDFET 98   green anole

6Q2J_E         81 LSvRNhGf-PLLTVYLKVFLSPTSLREGECq-WPGC----ARVYFSFFNTSF 126 
2_pfamImport   78 LQ-HS-W--SVKKLFLLAMVIPTFTRKSQC--IRNS----PRITLDFVNATM 119 
XP_005473896  104 L--YQ-RsrSVRKLFLQTMVRSEFTNKPLCl-MRKP----VQIILDFVNATL 147 
XP_022540397  103 LSsSA-Fg-HAKKLILKVVAA-PGNQRSICl-HHTK----VDVSLTFLNTTA 146 
NP_858048      96 LRsGS-VrsP-KDLTLKVGVSSTPPMKVMCt-ILPT----VEVKLSFINDTA 140 
XP_006630860   98 PS-NS-WtgPVKKLPLLARASQKPFRDKSCh-GQTVhgqdVSIYINFYNTTA 146 
XP_004077559  104 QYpTS-W--PVKRLSVQAVVSNSFIKGSQCa-AKRK----ALITLDFVNATM 147 
XP_023183795  104 LYqNS-W--PAKRLTLQVMALNSVSKRAPC--SRNS----AHITLDFVNGSM 146 
7AML_A         75 LRsGS-Vr-SPKDLTLKVGVSSTPPMKVMCt-ILPT----VEVKLSFINDTA 119 
XP_016851013   99 LFaGN-Wm-SMPKLILQVYLTSQPLQGKDCreSYNK----ALVKLSVINGTM 144  green anole
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