pfam16568: Sam68-YY (this model, PSSM-Id:465182 is obsolete and has been replaced by 465182)
Tyrosine-rich domain of Sam68
Sam68-YY is a short tyrosine-rich domain on Src-associated in mitosis, 68 kDa protein (Sam68), a protein that regulates TCF-1 alternative splicing. It is a crucial binding-partner of the APC-Arm domain that forms a superhelix with a positively charged groove, the surface-residues of which groove form numerous interactions with Sam68-YY to fix it in a bent conformation. APC-Arm is the armadillo repeat domain of the tumour-suppressor protein adenomatous polyposis coli or APC. APC plays plays important roles in Wnt signalling and other cellular processes.
Jiyao W et al.(2023). "The conserved domain database in 2023.",