5H3O


Conserved Protein Domain Family
CLZ
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pfam16526: CLZ (this model, PSSM-Id:465160 is obsolete and has been replaced by 465160)
C-terminal leucine zipper domain of cyclic nucleotide-gated channels
The CLZ domain is the C-terminal leucine-zipper domain of of cyclic nucleotide-gated channel proteins. The CLZ domains form homotypic trimers in solution thus constraining the channel of the CNGs to contain three cyclic nucleotide-gated subunits, CNGA. The CLZ domains formed homotypic parallel 3-helix coiled-coil domains, consistent with their proposed role in regulating subunit assembly.
Links
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Statistics
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PSSM-Id: 465160
Aligned: 47 rows
Threshold Bit Score: 52.1698
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5H3O_A       614 LLAKGREILKKDNLLDE----NAPee--qKTVEEIAEHLNNAVKVLQTRMARLIVEHSSTEGKLMKRIEMLEK 680
4_pfamImport   1 LEEKGRQILTKMGMLEEs--gEHVde-eaDKLENKIGSLESKLEILQTKLARLMSELESSHRKMQARVEQLEW 70 
XP_026000822 424 LEEKGRQILTKMGMLEEsg-eKEEge--gEKVETKIQRLESNLEVLQTKLARLMMELESSNRKMQARVAQLEL 493
XP_027878501 424 LEEKGRQILIKMGMLENra-eVEEve--aEKVETKIERLESSLELLRTKLARLMVELESSNRKMRARVEQLEM 493
XP_020568859 461 LEEKGRQILVKMGMLDEsa-eEGDgd--aDQIETKLTKLEDHLELMQTKLARLMVELESSNSKMQARVERLEW 530
OCA17731     485 LEQKGREILLKMNKLDEqladELAak--eQELEMKVGRLESNLDSLQTKLARLLAELESSAVKMTQRIRQLEW 555
EHB06726     464 MEEKGREILLKMNKLDVn--aEAAeialqEATESRLRGLDEQLDDLQTKFARLLAELESSALKIAYRIERLEW 534
XP_010704542 398 LEAKGREILLRMDKLDVhaeaAAAaa--rEEAERRAQVLEAALEALQTRTARLLAQLESSALKLALRIGRLES 468
XP_016854267 456 LEAKGREILLQMGQLDTq--vEAReeaqrREEQRRTQALQLRLDALQTRLARMLAGLESGALKLTLRLERLEG 526
NP_001027710  10 ML---K--LDKENAIDRa--eQAEtd--kKSAEDKATGLEEELQGLQKRLKATEDELDTSQEKLRTAIENLEn 73  vase tunicate
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