Conserved Protein Domain Family
Cadherin_C_2
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pfam16492: Cadherin_C_2 (this model, PSSM-Id:465139 is obsolete and has been replaced by 465139)
Cadherin cytoplasmic C-terminal
Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.
Links
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Statistics
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PSSM-Id: 465139
Aligned: 115 rows
Threshold Bit Score: 39.816
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002804241   713 DLTLILIIALGSVSFIFLLAMIVL-AVRCQKEKKLNIYTClasdcclcccccggggstccgrqararkkklsksdimlVQ 791 
11_pfamImport    1 NLTFYLILSLSLVSFLFMASIIVIiSLKFYRWRQSRFLYK--------------------------------------SN 42  
XP_015796778   465 NLTFYLVLALAVVSFLFITCLVVIiSVKIYRWRQSRILYH---------------------------------------- 504 
XP_015796778   465 NLTFYLVLALAVVSFLFITCLVVIiSVKIYRWRQSRILYH---------------------------------------- 504 
XP_016284549   689 NLTFYLLLSVILVSVGFAVTVLGViVFRVYKWKKSKNLYS--------------------------------------SS 730 
XP_016848988   688 HLTFYLILAVILISVAFFVTVVGVgIYKFYKWRQSKDIFK--------------------------------------AS 729 
RXN25635       109 KLTFYLIIALVSVSTFFLTFIIIIlAVRFCRRRKPRLLFD---------------------------------------- 148 
XP_006632063   684 HLTVILIISLAAVSFFFLTFIVVIiAVRFCQRGKRRLLLD--------------------------------------GA 725 
XP_017570653   675 NMTFYLVLALAAVSVLFIFSVIAIiSVKIYKWRQKRLFYK---------------------------------------- 714  red-bellied ...
XP_016426461   136 NLTFYLVLALAVVSFLFIVSIIAIlSVKCYRWRRERMFYK--------------------------------------SG 177  Sinocycloche...

XP_002804241   792 sSnVPSNPAqVPVEES----GGFGSHHhnQNYCYQVCLTPESAKTDLMFLK 838 
11_pfamImport   43 vT-LPVIPS-AYYPPRyadvGGTGTLQ--HVYNYEVCLTTDSGKSEYRFIR 89  
XP_015796778   505 ----SSLPViPYYPPRysdtLGTGTLQ--HVYNYEVCRTTDSRKSD---CK 546 
XP_015796778   505 ----SSLPViPYYPPRysdtLGTGTLQ--HVYNYEVCRTTDSRKSDCKFGR 549 
XP_016284549   731 gSsLYRTPGpSLHVDA----VRGGLMS--PHLYHQVYLTTDSRRSDLLLKK 775 
XP_016848988   730 rSsLYRTPGpFNHIDT----VRSGFTP--PNFYQQV-LTTDSRQSDLLYKM 773 
RXN25635       149 -G-AVAIPS-AYLPPNyaevEGAGTLR--STYNYDAYLTTGSRTSDFKFVR 194 
XP_006632063   726 v----AIPS-AYFPTSyadvVGTGTLR--HSYNYDAFLTTGSSTSDFKFVR 769 
XP_017570653   715 -S-AANLPViPYYPPG----YADGTLQ--HVYNYEVCGTTDSRLSDIKFvr 757  red-bellied piranha
XP_016426461   178 aN-LPVIPYyPPLYADv---GGTGTLQ--HVYNYEVCRTTDSRKSDLKYGR 222  Sinocyclocheilus rhinocerous
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