4NDI


Conserved Protein Domain Family
zf-C2HE
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pfam16278: zf-C2HE (this model, PSSM-Id:465082 is obsolete and has been replaced by 465082)
C2HE / C2H2 / C2HC zinc-binding finger
zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.
Links
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Statistics
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PSSM-Id: 465082
Aligned: 100 rows
Threshold Bit Score: 43.4316
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4NDI_A              123 NTEYFLESQAVIe----mVQEAGRVTvrdg---mpelLKLPLRCHECQQLLPSIPQLKEHLRKHWTQ 182
XP_002054592        127 NTDLFITFQAVYa----lLRVNGSVEpmpadkaeelrMATPIHCNQCSFITDNFNKFKIHLYDHWRK 189
XP_001999372        127 NSDLFITFQAIYa----lLCVKGSVEpmpaeqveqllHATPVHCNQCSFYTENFGQLKRHLYIHWRE 189
WGS:AANI:GJ22722-PA 124 NTDVFITYQAVYa----lLRVQGSIEpmsperakalrKTMPLRCNQCDFESQSLVALKTHLFEHWKK 186
WGS:AAPU:GI16920-PB 123 NTELFLTYQAVYa----lIRVQGSVQpmpaekadelrKALPLRCNQCDFETNLLLGLKGHLFEHWKN 185
Q16F08              122 RTDLFMPFESVLl----eLQERGHIKhrpea-yinslMDARLECNQCDRQFDTLPALKEHLLDHLNS 183 yellow fever mosquito
EDS31274            121 VTEFFMPFESTLtgivleLQDKGRIErrsqe-liehlLRLPLACNQCAFPCSTLPQLKKHLESHLDS 186
EDS31272            127 NTAYFMPFEDILn----eLKEKGKIArrpka-lidrlLQTPLVCNQCPDRFDSLGGLKSHLDNHWLE 188
ETN58038            121 HTDFFLQTEVAIe----rLRTHGSIEwlpqp-vltawISAPLKCNQCSYHPKTFHDLKKHLQQHAEQ 182
XP_001996255        312 NTALFLTYQTAYa----lLRVQGFIEpmpeeemqklrNSIELRCNQCDFVSKGLVVLKAHLFTHWKE 374
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