5FS8


Conserved Protein Domain Family
AIF_C
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pfam14721: AIF_C (this model, PSSM-Id:464279 is obsolete and has been replaced by 464279)
Apoptosis-inducing factor, mitochondrion-associated, C-term
This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.
Links
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Statistics
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PSSM-Id: 464279
Aligned: 30 rows
Threshold Bit Score: 159.35
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5FS8_A              363 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKs-----aTEQSGTGIRSESETESRAS 437
XP_009022515        298 AGMNMTGARKPYKHQSMIWSDIGPYIGFEAIGLIDSALPTVSVFAKLPNSSTP--------DTNIDDAKSQDSEKTDPNP 369
XP_002131727        455 AGENMAGGQKSYYHQSMFWSDLGPDVGYEAIGIIDSALPTVGVFAKATEKDTPKaaegaglRDDGAENPAENTEKQPTTT 534
KMY87587            526 AGENMTGAKKPYQHQSMFWSDLGPEIGYEGIGLVDSSLPTVGVFALPSESATR--------VDQLSESSDSDVPETSTSS 597
WGS:AAPP:GF14603-PA 591 AGENMTGAKKPYQHQSMFWSDLGPEIGYEGIGLVDSSLPTVGVFALPTNVAKR--------VDKLPESPENQSSESAPTS 662
XP_002051838        591 AGENMTGAKKPYQHQSMFWSDLGPEIGYEGIGLVDSSLPTVGVFALPSQSEKR--------ADSHIDVRSDASSKNVYKK 662
XP_002001664        597 AGENMTGAKKPYTHQSMFWSDLGPEIGYEGIGLVDSSLPTVGVFAIPSNNEKR--------ADSHTEVRADANADEQLKT 668
XP_001989001        537 AGENMTGAKKPYQHQSMFWSDLGPEIGYEGIGLVDSSLPTVGVFALPSPNDKR--------AVNHTEAVVDTTSSDRVKI 608
XP_001844711        527 AGENMAGKNKPYIHQSMFWSDLGPKIGYEAIGIIDSALPTVAVFAKASPAQI---------IPDTSEKLQAANATIIPAS 597
ETN64791            459 AGENMVGKNHPYTHQSMFWSDLGPRISYEAIGLIDSTLPTVAVFAKRSAEEL---------ARSIAGASDSEKLQAANAI 529

5FS8_A              438 EITIPPst----------------paVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKD 492
XP_009022515        370 QIKELTlee---------------tsSKLNSLDDDEYRKGIVFYLKDDVVVGVLMWNVFSGMSVARQIIQE 425
XP_002131727        535 TTTASS----------------------------EEFGKGVVFYLRQQKVVGVLLWNVFGRMPIARKMIRD 577
KMY87587            598 SQSSKSdaga------------sqdgVTCDPDEAGNYGKGVIFYLKNDKIVGILLWNLFNRIGLARTIINQ 656
WGS:AAPP:GF14603-PA 663 SNASVEksd--------------kdgVTCNPDESENYGKGVIFYLKNDKVVGILLWNLFNRIGLARTIINQ 719
XP_002051838        663 MTDGPD--------------------LVCDPNEAPNYGKGVIFYLKNDKIVGILLWNLFNRIGLARTIINE 713
XP_002001664        669 VTGPEM---------------------SCDPSEEPNYGKGVIFYLQNEKIVGILLWNLFNRIGLARTIINQ 718
XP_001989001        609 IGDGTE--------------------MSCDPSEEPNYGKGVIFYLQNDKIVGILLWNLFNRIGLARTIISQ 659
XP_001844711        598 ATQTPSnssvlnhtsvvkaeamppkpAEPAREDADDFNKGVIFYLRDEKVVGVLLWNIFNRIGTARKIVAQ 668
ETN64791            530 GDGPKKeqav------------papaASKDQEPGEDFDKGVIFYLRDKKVVGMVLWNVFNRMGTARKILDQ 588
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