Conserved Protein Domain Family
eIF3_p135

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pfam12807: eIF3_p135 (this model, PSSM-Id:463717 is obsolete and has been replaced by 463717)
Translation initiation factor eIF3 subunit 135
Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.
Statistics
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PSSM-Id: 463717
Aligned: 138 rows
Threshold Bit Score: 103.419
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002550200         718 QAIPFEGKQLTETLHRSGINMRYLGFIAdkiisrreqflaeteelikaneaaaekkqkeeeekakqeaekakedtekgek 797 
XP_004039976         753 NSRLADSLSVSDCFHLNGVNIRYLGKVI---------------------------------------------------- 780 
WGS:AATM:SJAG_01741  679 SAMPVDGIALARMMHKRGINMRYLGKVAe--------------------------------------------------- 707 
EPY49490             706 SFMPIDGIALSRALHRNGINIRYLGDML---------------------------------------------------- 733 
O59742               704 SFLPIDGVALCRAMHRSGINIRYLGEIA---------------------------------------------------- 731  Schizo...
A8XAA9               745 TVQPIDGNNLADILHSKGINIRYLGEIG---------------------------------------------------- 772  Caenor...
EGT33487             747 TLQPIDGENLADVMHAKGINIRYLGEIG---------------------------------------------------- 774 
XP_003113293         745 IVQPIDGDNLADVMHSKGINIRYLGEIG---------------------------------------------------- 772 
P34466               744 VVQPIDGDNLADIMHINGINIRYLGEIG---------------------------------------------------- 771  Caenor...
1_pfamImport           1 MLQPIDGENLSEVMHNKGINIRYLGEIG---------------------------------------------------- 28  
XP_002550200         798 keddkevkseeeeeeetpTKATYQLSLASYst------lyRVVVQEMIARASKHVLRDLTKNVSDYLIPYVVAHFHNCLL 871 
XP_004039976         781 ------------------NSLNQNDYPHIL----------MILQKTLLVKCLKHVLREIMRLSVQNEIPYSISNALNCIF 832 
WGS:AATM:SJAG_01741  708 ------------------LAASQYGNDHPLvy------laEL---EMLARAVKHVFSNNIAKHSFYNRASSVAYLLCCIF 760 
EPY49490             734 --------------------------YVILdkypentamiRLFTSEIFARSAKHLIRAYISKTPRCLISHVVSHFFNCLL 787 
O59742               732 --------------------------NIILqkspnnvillKLVTSEIFIRSIKHVFRNFLAVVPQVLRSHLLSHLLNNLF 785  Schizo...
A8XAA9               773 ------------------KRVQDTNSFAR-----------PLVLSDIVARSAKHVIRKINVQTPVDQLVVSTSHILNCLF 823  Caenor...
EGT33487             775 ------------------KRLQDTNSFAR-----------PLVLSDIVARSAKHVIRKINVQTSADQLSSSTSHILNCLF 825 
XP_003113293         773 ------------------KRIEDSNLFAR-----------PLVLSDIVARSAKHIIRKINVETLADQLSASTSHILNCLF 823 
P34466               772 ------------------KRLENSVSFAR-----------PLVLSDIVARSAKHVIRKINVQITADQLSASTSHILNCLF 822  Caenor...
1_pfamImport          29 ------------------KRIEDSNTFAR-----------PLVLSEIVARSAKHVIRKINVQVTADQLASSTTHILNCLF 79  
XP_002550200         872 GGDINQT----------PSVDIP---HKNFYS----ESEL------------------------EFTKLEHKDILQLLSQ 910 
XP_004039976         833 SVSDIRDrlekgeicqqKNNTNNe-nMGGGEKnkqgKKNKkqhsnkqqkiqvlnksncivlpqwEVSKLKPSQIWEKVLN 911 
WGS:AATM:SJAG_01741  761 SE---------------DEAFKDs-pVYKEYLqkipSESFq----------------------------TPTQVKESVAQ 796 
EPY49490             788 AESEDDQs---------FPFLPEe-sISQFYPet----------------------------cqMLVSMSPKLVSEALMK 829 
O59742               786 TVYGYVEp---------TKPLINe-nIANLFFqa----------------------------tqVIYSINSTSLYSSIKK 827  Schizo...
A8XAA9               824 -----------------STVSEPs-pVASHAHkkssKKNGkkk------------------nsgVWATLTTASLWKSICE 867  Caenor...
EGT33487             826 -----------------SVVSEPs-pVGTTATkkanKKNGkkk------------------tagIWSALTTASLWKSICE 869 
XP_003113293         824 -----------------SVVTDPs-pVATNATkksnKKNGkkk------------------stgVWSTLTTASLWKSICE 867 
P34466               823 -----------------SVVLDPs-pIAANVAkkanKKNGkkr------------------vtsAWSSLTTSALWNSIRE 866  Caenor...
1_pfamImport          80 -----------------SLVGEPspsLANPAGkktnKKNGkkr------------------nnqVWTSLTTASLWKNICE 124 
XP_002550200         911 QVFIRFRFTL----PENWISE-----SVS--LPALFREIAVKYGIQWKSSHYVF 953 
XP_004039976         912 LAKKRYGYDGfpenMSNLNLL-----NLKfnKLSILRDLLRTIGVQILYKDYYF 960 
WGS:AATM:SJAG_01741  797 NVASRFRYRIh--nSAKFVK-----------SPPLLRNICLKLGIQLLCRDYFC 837 
EPY49490             830 ESQSRFGYKI----PREFVK------EVN--QISLIRLICLKLGIQLACKDYVS 871 
O59742               828 EASSRFRFNL----TDDLLH------SLN--PICILRGTCLRLGIQISCKDYFS 869  Schizosaccharomyces pombe 972h-
A8XAA9               868 ESAYYYGYHI----DTETLDKfleqhEIQ--KTALFRRVVKIMGVQIVARDYQL 915  Caenorhabditis briggsae
EGT33487             870 ESAYYYGFSI----ESESLDKfiethDIQ--KTAIFRRICKVMGVQLVAKDYQL 917 
XP_003113293         868 EASYYYGYPI----DAESLDKfteqhDIQ--KTALFRRICRIMGVQLVARDYQL 915 
P34466               867 DSASYYGYPI----EADSLEKftelhDIQ--KTALFRRICKVMGVQLVARDYQL 914  Caenorhabditis elegans
1_pfamImport         125 EAEYYYGYKI----DSESLEKftelhDIQ--KTALFRRICRVMGVQIVARDYQL 172 
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