Conserved Protein Domain Family
PKK
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pfam12474: PKK (this model, PSSM-Id:463600 is obsolete and has been replaced by 463600)
Polo kinase kinase
This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.
Links
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Statistics
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PSSM-Id: 463600
Aligned: 56 rows
Threshold Bit Score: 80.298
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_018667614  959 YQTTKQQIKDQYHLQRHQLVIRHDKEQEQMHRHNKRSREELISHQQQEKVRLPKIQRSEGKARMSMFKRSLRIQSTYegK 1038
XP_015792140 1140 HQLAKRQLEDIIKLQRIQIFTRHEKELEQLKRMSQRQEDQLLKRQAVERRQLPKHIRAEMKARELMFRESLRCSSAN--L 1217
EEZ97987     1050 HQLMKRQIKEIFILQRHQMLTRHEKEKEQIKRRAARKEEELLKKQAAEKRSLPKRIRTEMKARELMFRESMRISISGt-N 1128
XP_002006903 1158 HQLSKRHVKELCFMQRHQMIVRHEKELDQVKRMLQRKEEDLLKKQTLEKRALPKRIRAERKARDLMFRESLRISTN---L 1234
ETN62420     1440 HQLAKRHVKDICFMQRHQMIIRHEKELDQIKRMITRKEEELVKRQTIERRALPKRIRAERKARDMMFRESLRISMT---T 1516
XP_028034415  899 YQLAKRQLKDEFLLRRQQMLVRHDKELEQIKRKNTRKEEELAKCQALEKRSLPKRIRAEQKAREMMFRESLRISTAP--Q 976 
KAE9428136    193 HQLAKRQLKDSFFLQRHQMLIRHDKELEHMKRLNARKVEDLLKRQNIERRAHPKRIKSEMKVREMMFRESLRIRMANn-P 271  Apolygus lucorum
XP_003105520  871 FVLHRKLFKDEYYLLRTQMLARHQREMAQIEKNHQEEEEELIRALTLDRKKLPKMLRAETKTRSVMFKESLRISSTN--M 948 
PDM66189      982 YVLHRRLLKDKFFLLRTQMLARQQKELQQAQKLHAREEEELIRALATDRKRLPKMLRNEAKTRSAMYKESLRISMAD--P 1059
XP_003383893  688 HQLQKQQVREAFHMQRHQMQMRHQKEYDQQLRRDNFRLDELKQTQLFEKKQLPKQLNAEFKVQLNELRKTMGL------R 761 

XP_018667614 1039 AAVNe-rEKIKQFTITETKRMKAEKLKQHLKHEtQLKELDARSEANMRELMQLQNEKRRMVVDHE 1102
XP_015792140 1218 HNVEderERIRKWQESEKLRYKAQQQEQENKHRkQLEDLRAASEAAIRELEHSQNEKRKSLLNYE 1282
EEZ97987     1129 DPEAe-kNKFKEFQEKEKKRYQAEQQRFELKHQrQLEELRAMSDATIKELEQLQNEKRKMLLEHE 1192
XP_002006903 1235 DPEMe-rDRLKKFQEQEKKRYMQEERRFEVKHQkQLEELRATRESAIRELEQLQNEKRKALVEHE 1298
ETN62420     1517 DPELe-rEKLKKFQEQEKKRYNQEQLRFETKHSkQLEELRATSEGSIRELEQLQNEKRKQLLEHE 1580
XP_028034415  977 NHEDd-rDRLKKFQENEKRRYKAEHQRLATKHAkAREELKAQGEAMLRELEQFQNEKRKALMNHE 1040
KAE9428136    272 DPDHe-rNMLKKFQENEKKRYRLEAQRFDQKHQrQQEELRANSEQTIKELEQLQNEKRKMLMEHE 335  Apolygus lucorum
XP_003105520  949 SNSEm-qERIRRFDEQESLRMRAALEDHDMKSQkKLQALKDRHHAAVIELDEMQNEKRKQLLEKE 1012
PDM66189     1060 SGGDi-nDMVRRFDEQEKARVNQALRDHEMKSEkKIQTLKEKNAAEMKELEETQNENRKLLLEKE 1123
XP_003383893  762 RTAEd-kAKLKKLEQRYIIKEESERSLMKEKHTrDLETQKAEMENNIREMVEIQNEKKLTLTQQE 825
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