Conserved Protein Domain Family
SUFU_C

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pfam12470: SUFU_C (this model, PSSM-Id:463598 is obsolete and has been replaced by 463598)
Suppressor of Fused Gli/Ci N terminal binding domain
This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologs. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologs.
Statistics
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PSSM-Id: 463598
Aligned: 14 rows
Threshold Bit Score: 247.712
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002429835        244 IEKGIETEGSNLGGVSAKCSWIEkdfdiecslheqssiiaksE----------LGGPRISEQ----ESQQIKSELKK--- 306
1_pfamImport          1 VDEGIEADGSNLSGVTANCAWSE-------------------Nf---------VVNQKSCQNflvtVGDQYHSEFLRyni 52 
XP_008187827        255 ITEGIKTEGSNLCGISAHCSWEElnnrcdkala--------------------------------------------yns 290
EFX89751            269 VEHGIDRDGCSLSGVSARCHWEErkvtsk--------------------tgsawrSPEAEDDsssqDDEEDEPEAGAtlg 328
WGS:AAPP:GF17874-PA 253 LQDDLEKQGSDLAGVNAEFSFRElkpkkevkkevdfhalsekCan-------eENNRPLTESlfkrEEPSFPQSMSIssn 325
EDW24939            251 LQDDLEKQGSDLAGINADFTFKEtkptivkqe-vdfqslserCat-------eENNRPMTESqmkrEEPSFPQSMSLssn 322
XP_001842898        245 LEIDLEKEGSDLAGVNADFTFKElpki------------aikKeivd---peeEITKSISSCnieiKKEFN--DGLEhsg 307
Q7PYI0              251 LELDLEKEGSDLAGVNADFTFKElakgal--------tvavkKevld---pdeDLSRSISSCniavKEEANEKDTLEqst 319 Anophele...
XP_001601038        277 VQSGIAREGSNLSGVSAKCWWVQmgdkstqkyreqrqesdeeDdgelepeeeiDIKPNIKSErlspCEQDVKMSVEQds- 355
EKC30433            252 VEQGIETEGSNLSGVNSRCSWEEpgengddyynedmkdnrtvDerrn---sneIDRPRISDF----ESEQIKATLQK--- 321
XP_002429835        307 ------GL----LsskpginnsliktedfedfdryvlfflpnvsvrksdimfqgnfaestelvHVVHLEGIHLTFNLESG 376
1_pfamImport         53 frfvtiKLliltNfyrgrnslglg-----------------------------nsgfettellQTKVLENVHLTFNLESG 103
XP_008187827        291 vehsmnNLriinNsrapnedlketdg------------------------nsnykscelselnQGQFIENVHITFNLEAG 346
EFX89751            329 rhrpadGEptinGeiw----------------------------------------------piRRLYKGVHLTLNLEAA 362
WGS:AAPP:GF17874-PA 326 slhkscPLd--fQpla----------------------------------------------pnCISLDGIEITLAPNVA 357
EDW24939            323 slhkscPLd--fQpqa----------------------------------------------pdCISLDGIEITLAPTVA 354
XP_001842898        308 ---ssdMVnpfhHsqv---------------------------------------------psRVSPLNGIELTLAPYAA 339
Q7PYI0              320 gstssdMVnpfdNpni---------------------------------------------psRVFPLTGIELTLAPYAA 354 Anophele...
XP_001601038        356 -----nGL---------------------------------------------------------KTLMGLHLTFNLEAG 373
EKC30433            322 ------GLqfprrdsrefeydntrr---------------------kqsfdsigssegptellRTRTLDFVHLKFNLEAG 374
XP_002429835        377 ILLPLALRGRVKHGRHFTFKSVLGDTAITFVASSVTGTFVNSDHPYAAHGPWLQVLIPDDFATEMITDIEMLnQ-NTDEI 455
1_pfamImport        104 SLLPLAIRGRVKHGRHFTFKSACSPIAITFVAESVTGSFVDVDKPYVAHGPWLQLLLNEDSSNQLLEKLQPLiS-HPEQI 182
XP_008187827        347 LLLPFVLKGRIRHGRHFTFKALTGDATITFVASAVSGSLVSEEKPFVAQGSWLQVLVSNSFLDSMESSLKFL-N-EPVME 424
EFX89751            363 SLLPVVLRGRLRHDRHFTFKAVAGETAVTLLTSRVGGALASPSAPLVAKGPWLQILVDSEWLAKLESDLACL-Q-QPDGV 440
WGS:AAPP:GF17874-PA 358 KYLLLAIKDRIRHGRHFTFKA--QHLALTFVGETVTGCAVSKKEPYGVLGYWVQVLIPEDLVPRMLEAFRGAgLnETCEP 435
EDW24939            355 KYLLLAIKDRIRHGRHFTFKA--QHLALTLVAETVTGAAVSVHEPYGVLGYWIQVLIPNDLVPRMMDDFRNAnLdENTEL 432
XP_001842898        340 KFLVLAIKDRIRHGRHFTFKA--QNMAVTFVSESVTGSIVTKDSPYGVLGYWVQILIPNALIPKMIDTFSDLnS-SVDNL 416
Q7PYI0              355 KFLMLAVRDRIRHGRHFTFKA--QHMAVTFVAESVTGSIVNRQTPYAVLGSWVQILIPNRLVPRMVERFGELsTrSADGL 432 Anophele...
XP_001601038        374 TLLPLAIKGRVMHGRHFTFKSILSHAAVTLVPPSVTGTFATKEKPYAVQDPWLQVLLPDELTERMAQEFQVL-N-APEQL 451
EKC30433            375 SLLPLALKGRLRHGRHFTFMSALNDTAVTLVSTSVNGSIADENHPFAAHGPWLQVLLTDDFIEEMIVDTEEL-V-HPDEI 452
XP_002429835        456 TFPKTFAWPDRKIVITI 472
1_pfamImport        183 MLPQTYTLNDKKLSITI 199
XP_008187827        425 PLPKTVNWPDRNLTITI 441
EFX89751            441 VVPKTFCWFDRQMALTV 457
WGS:AAPP:GF17874-PA 436 AQRIELEWPDKNLKLIV 452
EDW24939            433 TQRLQFDWPDKNLRLIL 449
XP_001842898        417 KIPLTYEWPEHNLKFII 433
Q7PYI0              433 KIPLTYEWPEQNLKFII 449 Anopheles gambiae str. PEST
XP_001601038        452 QLPKTFTWPEYKLAITI 468
EKC30433            453 MCPKTYSWPERRLMITI 469
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