2XXL


Conserved Protein Domain Family
CLIP
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pfam12032: CLIP (this model, PSSM-Id:463440 is obsolete and has been replaced by 463440)
Regulatory CLIP domain of proteinases
CLIP is a regulatory domain which controls the proteinase action of various proteins of the trypsin family, e.g. easter and pap2. The CLIP domain remains linked to the protease domain after cleavage of a conserved residue which retains the protein in zymogen form. It is named CLIP because it can be drawn in the shape of a paper clip. It has many disulphide bonds and highly conserved cysteine residues, and so it folds extensively.
Links
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Statistics
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PSSM-Id: 463440
Aligned: 173 rows
Threshold Bit Score: 38.1565
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2XXL_A               32 CTTPDGDQGQCMPFSSCRTIEERLTEaqkagQKvPADYASYLQKALCG-EF-NGVRHFCC 89 
XP_001954293         29 CTTPDESNGRCINLRECGYLFEVVQR-----GViSPEDREFLKSSQCGyRN--GQVLVCC 81 
EDW54810             29 CTTPDENSGTCINLRECGYLFELLQS-----EEvTDQDRRFLQASQCGyRN--GQVLICC 81 
XP_001993814         25 CTTPGEQIGICIPLRECDYLFELLQR-----SP-TASERTLLQRSQCGnRD--GQVQICC 76 
WGS:AAQB:GK10951-PB  29 CTTPGEQSGSCIYLRECDYLFELVQM-----QPiSNSNRALLQNSQCG--YrNGQVLICC 81 
WGS:AANI:GJ14460-PA  25 CTTPTDQSGTCIHLTECNYLFELVQK-----RTiSAANRALLQNSQCGyRN--GQVLICC 77 
Q17B76               24 CTGPDGRAGNCILLRSCDSLFTLIKK-----KPlLPEDRSFLSRSQCGwSQqENHPLVCC 78  yellow fever mosquito
ETN59198             78 CLLPDSGVGQCILLRNCTPLYNMIRQ-----RPlPDADRLYLQRTQCGwSTaEKHPLVCC 132
Q7QB73                1 CTLPDSTVGECILLRNCNSLLTLIRK-----KPlLDADRTYLQRSQCGwSAaENHPLVCC 55  Anopheles gambiae str. PEST
EDS32818             29 CNAPDGKPGRCILLRSCNSLFALIKK-----KPlEQEDRAFLSRSQCGwSRtENHPLVCC 83
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