Conserved Protein Domain Family
HIF-1
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pfam11413: HIF-1 (This model is not part of the current CDD release)
Hypoxia-inducible factor-1
HIF-1 is a transcriptional complex and controls cellular systemic homeostatic responses to oxygen availability. In the presence of oxygen HIF-1 alpha is targeted for proteasomal degradation by pHVL, a ubiquitination complex.
Links
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Statistics
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PSSM-Id: 463274
Aligned: 12 rows
Threshold Bit Score: 41.5125
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_023819367 523 TERDLCDLDLETLAPYIPMDgEDFQLNPIIPEP 555
2_pfamImport   1 TTQAMEDLDLEMLAPYIPMD-DDFQLRSLTPEE 32 
Q6EHI4       543 STQPMEDLDLEMLAPYIPMD-DDFQLRIPSPLD 574 zebrafish
XP_005986474 547 STQEAEELDLEMLAPYIPMD-DDFQLRSFDQLS 578
3_pfamImport   1 TLENVEEMDLDMLAPYISMD-DDFQLTLLNTLP 32 
XP_019659156 478 IAQDVDTLDLEMLAPYISMD-DDFQLNSSEQLP 509
XP_031819704 584 VEQDIEALELEMLAPYISMD-DDFQLNTSDQ-P 614
4_pfamImport   1 TPFTTQDLDLEMLAPYISMD-DDFQLPCVAVEE 32 
XP_023208360 553 NTEGMEDSELEMFAPYISMD-DDFQLPCLGPDE 584
1_pfamImport   1 FNCDQCELDLDSLAPYIPMHgEDFLLTPIIDRA 33 
XP_004753054 516 SQTDFSELDLETLAPYIPMDgEDFQLSPIYPEE 548
XP_009305016 522 SQLNLSDLDLETLAPYIPMDgEDFQLHPICLEE 554
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