6J4X


Conserved Protein Domain Family
RNA_pol_Rpb1_6
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pfam04992: RNA_pol_Rpb1_6 (this model, PSSM-Id:461511 is obsolete and has been replaced by 461511)
RNA polymerase Rpb1, domain 6
RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 6, represents a mobile module of the RNA polymerase. Domain 6 forms part of the shelf module. This family appears to be specific to the largest subunit of RNA polymerase II.
Links
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Statistics
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PSSM-Id: 461511
Aligned: 117 rows
Threshold Bit Score: 109.896
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6J4X_A        874 LDGTQVE-RQTIdTIPGSDKAFHKRYYV-------DL-------------M--DEKNsiKPd---------VIEYAA--D 919  Komagataella ...
A0BYP5        879 MAAEFIE-HQEIkCVNLSNAQLEEKYEL-------IKeqwfgseirqkyqN--------------------ILTEDVikD 930  Paramecium te...
XP_004027344  336 LAGEYIE-TQKIaEIEYSNEQFEKEYRFi-----------------------rDFENqvSIkeflereyerKLNKDVisE 391 
CAM70645      852 LDGARIEgNQAFpIPHMTNSEMADKYRY-------EY-------------NdeGSFSenMGg--------hYMDPFVrdS 903 
Q57YU2        875 LDGARIEgGQLFpLPFRDDKEMEDTYKY-------EY-------------DvdGTFSgkVGg--------nYMDPHVrkM 926  Trypanosoma b...
Q4DDX5        859 LDGARIEgGQLFpLPFRDNKEMESTYKY-------EY-------------DetGAFNekVGg--------aYMDPHVkkM 910  Trypanosoma c...
Q7T6X5        869 GINTENQvDQKIdLISANDNKVRNDYVYt-----------------------eDEIKylIKn------------------ 907  Acanthamoeba ...
Q4N0F9        886 MGAEYIE-DQFIdLMRLDDEEIHRRFSH-------DF-------------RseSYGLgwI-------------SEEIrnA 931  Theileria parva
EDO05418      886 MGAEYVE-DQTLdLMKLDFASLNRLYAH-------DF-------------RneNYGVgwI------------LDESVrtN 932 
XP_001007918  884 LAGEFIE-TQKIgEVDYKEEDFQKEYRFvkanksdDWlfqytkldqmenqIskEISRdvLI----------AIKEEFmrM 952 

6J4X_A        920 I--LGDVE-LQKE-----LNSEYEQLVSDRKFLREiVFV--Ng--dHNWP--LPVNLRRIIQNAQQIFHL----DRAKA- 980  Komagataella ...
A0BYP5        931 I--EEDFE-GQAL-----LKGEFDEIKKIRNELRRlFLIdsApkeeLFTHyyLVVNIERIISTIKINKKI----SDREK- 997  Paramecium te...
XP_004027344  392 I--DESARqSRQKyepfcLEEEYRDLLEARDLFRKcFYFysFk---QSLDlnIPVNIDRMLRSTKIEMSKnnriYDKDE- 465 
CAM70645      904 L--LRDPQ-SVLK-----LQEEFEQLMKDRAMSRLvIDMed----kNKLKmnLPVNVARLIQNARTTMGK------RSQv 965 
Q57YU2        927 L--RADPQ-NVRK-----LQEEYEQLTADREWSRKmLDLed----rDKLKlnLPVNPGRLIQNARSTMGK------RSQv 988  Trypanosoma b...
Q4DDX5        911 L--RADPE-NVRK-----LQSEFDQLMADRDWARRmMDLee----rEKLKlnLPVNIGRLIQNARSTMGK------RSQv 972  Trypanosoma c...
Q7T6X5        908 --hKTDKRyTTDL-----NNSLYRKLISMRDQLRRiQRLvnLtsaeFKETykMPVDIQQFIFNIINR-------DVRNNn 973  Acanthamoeba ...
Q4N0F9        932 I--LSDFS-QQVI-----LVEEFQKLLDLKKMICEeIFPsgD------YSqhLPINIKRILEYATTQFPA------SST- 990  Theileria parva
EDO05418      933 I--LTDFS-KQVI-----LVEEYQRILDMKAILCKqVFPdgE------ARqhLPINISRLLEYAKTQFPT----TTESR- 993 
XP_001007918  953 IneRNEGEdPKFI-----LEQEYEELIEARNLFRKnFYFyaQe---GKLDinLPVNIGRMIESAKIEMSQknktYTRDQ- 1023

6J4X_A        981 SDLTIPEIIHGVRDLC-KKLFvl----------rgENELIKEAQQNATSLFQCLVRARLATRRILEEFRLNRDAFEWVLG 1049 Komagataella ...
A0BYP5        998 CRLNPIYVTQQVDELI-QKVDkl-------------lsYDLEERKDCINLFRTHLKVSLASKDLCCRHRLTPEAFQELIS 1063 Paramecium te...
XP_004027344  466 SRLSPIYVYRVINELF-TKLD--------------NDAINRGVDPNALMLFKAHVRLHLSSKKIVIKHKINKEKFEQLVR 530 
CAM70645      966 SNLNPITVINRVRELQ-EDLAqlfpsyhkdyngrfANVLSQQRVERALTLFGIHLRQILGSKRVLKEYKLNDKAFEYLLK 1044
Q57YU2        989 SNLSPITIIDHVRKLQ-EDLMklfpsyhrggdgyiRNTLSRERIESALTLFNVHLRQLLASKRVLKEYKLNDRAFEYLLK 1067 Trypanosoma b...
Q4DDX5        973 SNLSPVTIIDHVRKLQ-EDMLklfpcyhkgvdgriHNLLSRQRIENALTLFSVHLRQLLASKRVLREYKLNDKAFEYLLK 1051 Trypanosoma c...
Q7T6X5        974 VVVDPYYVLKMIKDMYyGSDSkimk------ynnrTSRIKKEDEKRIKFLMKIYLYDVLAPKKCTHVYKFSKQEFDEIVD 1047 Acanthamoeba ...
Q4N0F9        991 SKLNPVEIAQRTNKLL-ESLIiint-------sgpNDILSEEAQQNATILIKAHLRCHLNSRYLMEQVQISSLALDWVYG 1062 Theileria parva
EDO05418      994 KLMNPVDIAQRVQQLL-DSLTivvt-------sgpHDILAAEAQENATILIKAHLSTALNSRRLMEREKIGNLAFDWLLG 1065
XP_001007918 1024 CKTNPIQVYKSLLELF-KNLD--------------DYAVKRGMEYESLALFKAHIRLHLGSKKIVLRHKLSMEVFDKLTK 1088

6J4X_A       1050 TIEAQFQRS 1058 Komagataella phaffii GS115
A0BYP5       1064 EIIYKLKKS 1072 Paramecium tetraurelia
XP_004027344  531 EVEARYKQA 539 
CAM70645     1045 EIRTKYQQS 1053
Q57YU2       1068 EIRTKYHQS 1076 Trypanosoma brucei
Q4DDX5       1052 EIRTKYLQS 1060 Trypanosoma cruzi
Q7T6X5       1048 -----YFKK 1051 Acanthamoeba polyphaga mimivirus
Q4N0F9       1063 EVERCFFKA 1071 Theileria parva
EDO05418     1066 EVKRIFYKS 1074
XP_001007918 1089 EIFDKFKKA 1097
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