Conserved Protein Domain Family
Mitofilin

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pfam09731: Mitofilin (this model, PSSM-Id:430783 is obsolete and has been replaced by 430783)
Mitochondrial inner membrane protein
Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.
Statistics
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PSSM-Id: 430783
Aligned: 17 rows
Threshold Bit Score: 352.907
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6PFS4        39 GSSAGKiva---aslLTVGGGLGGTILYAKWDPKFRSSIEKS-VPYSDQLFDMVLGAPPsppvpi----------qkkpe 104 zebrafish
Q55BP9        65 PFGFKP---------LIALVLVGGISAYLYKAWDNQDFMFSSkLPYQREEVEKFKKIMK--------------------- 114 Dictyostelium d...
Q2HCU4       115 KGFFRRlrnffltltLLSALGFGGGVWYSRINDNFHDFFTEY-IPYGEQAVLYLEEMD---------------------- 171 Chaetomium glob...
Q5K8K8        77 PRRFRRvfv---ytaLGVAGFYALSGYVGTKSDAYRDLFTQY-VPGGEAVADYADDNDWd-------------------- 132 Cryptococcus ne...
KIS72220      40 RSGLGRlfv---ystVGATVFYGISTVAALNNDRYNHFFVES-IPGGERIIDYLDTHDVgqeiksinlhgygdkaidvtk 115
P91928        68 EAGFGKvv-----lfVSPLAAVGGVITYAKYDDDFRKLVEKN-VPGAGSVIKVALQEEPpfkgitknvndqidkvksgie 141 fruit fly
1_pfamImport   1 EAGFGKvl-----vvLSPILIGGGVVTYAKYDNEFRKTLITN-VPALEPVLKTLLQETNpldev-----------skkmd 63 
DAA24582      40 rlSASKiag---agiLFVGGGIGGTILYAKWDSHFRKNVEKT-IPYSDKLFEMVLGSPPytvpl-----------pkkpi 104
NP_001006462  41 gVSVGKiig---asvLFVGGGVGGTVLYASYDPRFRENVEKA-IPYSDKLFEMALGPAPysvpi-----------pkkpv 105
Q9XXN2        20 SSGGLKfvg---atvGAVTAGAAGVAGYASYDNEFRKKLEGV-IPGSRTILNYTIGEEEppap--------------rlk 81  Caenorhabditis ...
Q6PFS4       105 TVKPLQISSLSEATKDSKQPKAKAKKSDpapppsveeapapa---palqsleeasaeaAHI-ISAISEVPSVPAPGTSDE 180 zebrafish
Q55BP9       115 EIHQDSQRENLNIEKESKESKESDQQQQh-----------------------------QQQ-QQQQHHQQEEEKEEEKVG 164 Dictyostelium d...
Q2HCU4       172 -FKKRSLTWLAGWETAG------------------------------------------RQ-SSAVQKVAAAKEPSKKAE 207 Chaetomium glob...
Q5K8K8       133 NVSGKAVRAWQSITGARPETRTEKVERKi---------------------------------GEVRQEAAKVPAQVKDKA 179 Cryptococcus ne...
KIS72220     116 TAYDSVSGAVSRVFSGDAGASESAGDERd------------------------------AR-LRVSEARATAKAEADKLA 164
P91928       142 TVTSTVDSVTSKVTGLFGGGSGDDKSKKskvepv------------------katpaeEKR-PSKPSEVSKTEAKPVSKP 202 fruit fly
1_pfamImport  64 DISKTIGEYTSTITGFFGGGDEEKKQEKkpdlppitraksvhvpvpspplpkpepinlSDKvPEQPKKKPEAAAPKVTTA 143
DAA24582     105 QSGPLKISSVSEVMKESKQPASQPQKQKgdtsasttagdt------lsvpapvvqheeLIK-TDHPETGEGKPKPATSEE 177
NP_001006462 106 QQGPLKISSVAEVMKESKQPVPKPQ-------------------------------------TSKTEAVAPSEEKEDKEH 148
Q9XXN2        82 DLRPLQYSADPKVPPKPFEPKPVKKELIg-----------------------------VKEnLKETTEPKKIEKKPENPY 132 Caenorhabditis ...
Q6PFS4       181 SPSGHsaaaeecckectepepavkerpaeevtarlaQQDKAELDALAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAA 260 zebrafish
Q55BP9       165 VENTT-------------------------------LEDNIIESIKNHEEEMKNELVSLIESVQDKYAHSNDDEINADER 213 Dictyostelium d...
Q2HCU4       208 PVVV---------------------------------APPKEEAPKVPAPEVKAEEPKKPAPAPAAE------KKRPSKK 248 Chaetomium glob...
Q5K8K8       180 DEAKDhv----------------------------vGKHTASQKIHERAEELRKAVEQKTHEAEARLKELTGEAKHKVQE 231 Cryptococcus ne...
KIS72220     165 QRAKV-------------------------------AAEKAEHQAESALQAVQDKTSELVNRAKAAAERAEAKVRGQTTE 213
P91928       203 AAAAApapaa---------------------kpkdnPLPRDVVELEKAIELSAQLAVKEYNVAIGVLKGFNDDVRKVVDK 261 fruit fly
1_pfamImport 144 TATKAaaaataaapaksap---aapskpaplasggeTVPKSISDLEQQVEVAATIAIKEYGHAVDVLKSYTNEVRKVVDE 220
DAA24582     178 ASSTSvrerppe-----------------evaarlaQQEKQEQVKIESLAKSLEDALSQTARITQQAIVAQNAAVQAVTA 240
NP_001006462 149 EGSHAikerspd-----------------evaarlaQQDKEEQEKISALAATLEGALSSTARITLQAITAQESAVQAVNA 211
Q9XXN2       133 IGAK---------------------------------TPLNPQERNEKLTESLKNHLTQAEKATKVATSAKLETIRAIEH 179 Caenorhabditis ...
Q6PFS4       261 HTDKLREAMDSETPPDEKSTQalnealneraravddagea--------lfkakgeleklrsvidkaKQSKIDSARPQILA 332 zebrafish
Q55BP9       214 EMDSETGVSISDEISKLIEEH---------------------------------------------KQNEEESLPDLLDV 248 Dictyostelium d...
Q2HCU4       249 VTEKKAVENKPVEKQPEPETSlvpa-------------------------------------ttalTPAQKAFKAPEVDE 291 Chaetomium glob...
Q5K8K8       232 ATKDAPFNFSEGVEGIVRAAEsalhktehkaaeaadkvkpaearpsspfpdtqrprelkpetvtpqVPSYEGKKLYTGPP 311 Cryptococcus ne...
KIS72220     214 ASKDGRNIIQRAVDSVQVMTDigantkaapsksaap---------------gngpkeevketyigeLPVNHEAPVGYAAP 278
P91928       262 AVENGENSLWTTLKNRASARDtavataeraa-------------------------reaqekivacEIALSAAATAQNAK 316 fruit fly
1_pfamImport 221 SVDKLDSSSWTTLRNRTSARDtalqaaedaadk---------------------argnieklhallNSREIKCSDELKDK 279
DAA24582     241 HANILKAAMDDSEIAGDKKSAqwrtvegalkerrkavdeaa-----dallkakeelekmksvienaKKEEVAGAKSHITA 315
NP_001006462 212 HLQILKEAMDDSETAGEKKSAqwrtleealkdrrravdeaa-----dvllkakeelektkgvienaKKSQIPGAKSHIIA 286
Q9XXN2       180 HVQTIREAIEAGKDGDWDSVTvahlkakrlaekdekae-----------klarnavadlvteanlgGQGETTQLNPLVPI 248 Caenorhabditis ...
Q6PFS4       333 AEEN----------LHSMIVDLDKVVTKVQTAqseakivsqYSELVNEAKAQFQQELANITPEIQANWKGLSGkLSADDL 402 zebrafish
Q55BP9       249 NYGV----------LSIIPEAVKSAEETVENA---------LKKFTHSNDDDDDTTTTSIIINTSDELKNHNInIENGNE 309 Dictyostelium d...
Q2HCU4       292 PSRW----------PPASPid-------------------pLAVPNAADPVV--QDLVRMLNDIITVINHDGA---NDRY 337 Chaetomium glob...
Q5K8K8       312 LPLGhepppgyylpPPPSTKKEKVEEKVEEIKerlpllvpkVKEFASEEPII--SQLASTIDSLTSSLSTPSK-ALSSDA 388 Cryptococcus ne...
KIS72220     279 RRDR----------GLQAPDHPTARLRPDPEApklpllapsIKSLSASEPMI--AQLAGTIDELTVFLKETPS--SGAKA 344
P91928       317 KVEAvr------dkIKKLVDHIGNVKDELYRHkdtasvsdkYWRNVEKARNYFIDEIESIFPGLSLADKKLNL--SKEDL 388 fruit fly
1_pfamImport 280 ARQN----------IAAYLDHLKKAKEEVYAArdlaslgekYWKRVESARNYFVEEMESLFPGI--NLAERKLnLSKDEL 347
DAA24582     316 AEGK----------LHNMIIDLDNVVQKVQAAqseakvvsqYHELVVQAREDFKRELDSITPEVLPGWKGMTDkLSADDL 385
NP_001006462 287 AEEN----------LHHMIVDLDNVVKKVQAAqseakivaqYHELVATAREEFQRELDSITPDVQPGWKGLTGqLSTDDL 356
Q9XXN2       249 SKAT----------AEKLSNELDEMISNVKHVdserifvhdYSDRVAESRRKFQMELKAVHPNLN---YEDGMkIKKADL 315 Caenorhabditis ...
Q6PFS4       403 NSLIAHAHRRIDQLNReLAEQRVREQIHIEVALEQQKLEdQKAQERAVISALEHSRE------DMRLEQEKKVQEVREVM 476 zebrafish
Q55BP9       310 ESLVDSLDVNYNVLSI-IPEKVKSAEEKVENVLKKFEEQyLEKVEKLISENMKLKVDfdklinGKDDELKRVEEEIREKY 388 Dictyostelium d...
Q2HCU4       338 GATIGKAKNEISKVGQkILDIKTAVEKDAAQQVRQRVDG-FDQAANDLVARLEAAMTvq--eqQFRREFEAEMERLRKSY 414 Chaetomium glob...
Q5K8K8       389 TGILNKAQDDLTALNArLQEVKKAEKAKLEQSISEKKKE-----FEALLKSMEAEKAks--eeGLKQTWQHERQTMVEDW 461 Cryptococcus ne...
KIS72220     345 KGVLESAQIDLEQLSQrLETIKRQEAKRVEDSLAAQAKR-YETQISKQSQEAADKLSsr--esDWQKSFEEEHAKQTQQF 421
P91928       389 DLFILHAYTHVLAYQKeLQRLQTDGELRLKRAIDSVR---GDNDSEALRAQLEYHLEae--rrKLAVENQKKIFHIHAES 463 fruit fly
1_pfamImport 348 DLFILHAYTQVIAHQKeLQKLQIEGDQNLRRALEAVR---GSDQSEEVKARLEYEIAke--krQLNLLNQKKLLLTRAEL 422
DAA24582     386 NALIAHAHRRIDQLNRaLAEQKATEKQHIALALEKQKLEeKRAFDSAVAKALEHHRS------EIQAEQDRKVEEVRDAM 459
NP_001006462 357 NSLIAHAHRRIDQLNKeLAEQRVREQQHIELALEKQKLEdKKALEAAVAKALEHHKS------EIEIEQEKKVEEVREVM 430
Q9XXN2       316 HTILAHAHLRIDQLSQkLIDSKLNEEKRIQSIIAKKKEDlLEKLRLETNAKQAAVIPefd-kkKLDAELARATAEIQKKY 394 Caenorhabditis ...
Q6PFS4       477 EAEMRTQLRRQAAAHTDHLRDVlkvqeqelreeaQEILNSKMMEQEthyrrltqeqlDTFTLDMNAAYAR-LKGIEEAID 555 zebrafish
Q55BP9       389 RSSLDAAIEELNKDLDEKLKDM------------DQFIKSKVFDNQ-----------AVLQETLEKQKSNlINIFKQQAE 445 Dictyostelium d...
Q2HCU4       415 DNKVHLIQERERQLAEEKLNNQlleqavqlqrafTQDIKKHVEQER-----------DGRLGKLNELKAA-VEGLEKLTA 482 Chaetomium glob...
Q5K8K8       462 RKELEGELEQQRQSIEQRLREEvvsqgielqrrwLRSIKTQVETER-----------GGRLAKLDSLTTS-LKQLERITL 529 Cryptococcus ne...
KIS72220     422 KEKLEKELATQSQIINERLKEEviaqgielqrrwMKDIKAKVEEER-----------GGRLSKLDELATD-LKSLEKVSL 489
P91928       464 DKLLRLQLKKQAEAHADHIKDIvaqretdltrsfKRELEDKLATEK-----------ANYKLQLAGMLGK-LRGMDAALA 531 fruit fly
1_pfamImport 423 EQQMREQLKRQTEAHVDHLKDAltqkelemkrkfQRELDEKITTEQ-----------ASYKLQLAAMLGK-LKGIHNALV 490
DAA24582     460 ENEMRTQLRRQAAAHTDHLRDVlrvqeqelkyefEQDLSEKLAEQElqfrrlsqeqvDNFTLDINTAYAR-LRGIEQAVQ 538
NP_001006462 431 ESEMRTQLRRQAAAHTDHLRDVlkiqeqelkvefEQNLSEKLSEQEmqfrrltqeqlDNFTLDINTAYAR-LKGIEQAVE 509
Q9XXN2       395 DEKLK---------------EVvrtqkqlydiehAKDVDEAVLKER-----------NLHSSAVGKALAQ-LAGIEKALS 447 Caenorhabditis ...
Q6PFS4       556 SHVIAEEEARKAHQLWLSVEALNYTLKSAGADS-----PTEPLEGAVRAIKES-----CAENEFAQALAIAIPEESLNR- 624 zebrafish
Q55BP9       446 SIKQSELEKRAITQLTQCIVDLQKLLHDKSAIDga--nGKGLLVRSFKNLTDL-----SNYDQLIKELLSTLPEGFEKK- 517 Dictyostelium d...
Q2HCU4       483 GWNEVIDANLRTQQLHVAVEAVRASLEDAHH--------PRPFIKELVALKEI-----AAQDPVVDAAIASVHPSAYQR- 548 Chaetomium glob...
Q5K8K8       530 DNSATLDDNVRLHKIWSALRAVQSKVDSGD----------LAFDDELRALKSLstptaSSGEGVVRSALEQIEKSGIPQt 599 Cryptococcus ne...
KIS72220     490 DNSSVLDENLSVHTLWTAVRAVQHALDDASATK-------RPFAEQLRVLKGTs---kARDDPVLSAAIEALDASGAADt 559
P91928       532 ERADAERTANQAQALWAACQALWASVRAATPGVhy-kdRLRPLKNEINAIAKV-----AKGDDLVAAVLESVPKEAQER- 604 fruit fly
1_pfamImport 491 EHADAEKSAHQAQALWGACQSLWSSIRSGQPGKsw-rdQLRPLKDEIAAVARS-----AEGDELVTVVLKGLPETAVKR- 563
DAA24582     539 SHAVAEEEARKVHQLWLSVEALRYRMKTASADL-----PTVPLGSAVEAIRAS-----CSDSEFAQALTAALPPESLTR- 607
NP_001006462 510 SHAVAEEEARKAHQLWLSVEALKYCMKTASGDS-----PTEPLESAVKAIKAS-----CSDNAFTEALTAALPQESLTR- 578
Q9XXN2       448 GHLQMDIENRKSKQMWLATQNLKGTVIFGNRASccmegRRAPLGDQMKTLLSCcg--gGNSDEFVKTINTAMSKTSKVR- 524 Caenorhabditis ...
Q6PFS4       625 GIYSEASLRARF-YDIRRLARRVALI-DETRNSLYQYFLSYLQSVLLFERDQeapp-----aklAPEDLDTFKLLAYATY 697 zebrafish
Q55BP9       518 PVIPLDTLNNQF-QDIAKKLRKSQLI-DPNDNSLLGKAVSELASLFIIPEKG------------MVQGNDYDAILARAED 583 Dictyostelium d...
Q2HCU4       549 GISTPAELIDRF-RRVAAEVRKASLL--PDDAGVASHASSYVLSKVMFK-KQgl-----------aAGDDVESILTRTQT 613 Chaetomium glob...
Q5K8K8       600 GVKSFAALSSWFtNTVAPRIQSSSLVpAPEEATVISHLASAGLSKIMFRPQAgr-----------vPGDSVGAVLARAEW 668 Cryptococcus ne...
KIS72220     560 GVETFTTLKQWFdDKVGPRVRQVSLVpSPETSGVLSHLASAALSPILFH-KKgl-----------vPGQDVPSVLARAEY 627
P91928       605 GVYPEDALRERF-LNVERVARRLALV-PEEGAGLPIYFLSYLQSLFILRPDNpiskdelenkpfDYSKLDTYDILNRARY 682 fruit fly
1_pfamImport 564 GVYPEDALRERF-LKVEEVSRRLALV-PAEGARLPMYVLSYLQAALIARPDKpisqdelenkpfDFSKLDTYDILNRARY 641
DAA24582     608 GVYSEETLRVRF-YAVQKLARRVAMI-DETRNSLYQYFLSYLQSLLLFPPQQlkpp-----aelCPEDADTFTLLSYASY 680
NP_001006462 579 GVYSEEALRARF-YTVQKLAKRVAMI-DETRNSLYQYFLSYLQSLLVFHPQQlkpp-----aelSPDDLDTFKLLSYASY 651
Q9XXN2       525 GEYTEQDLNTRF-NKVCRIGRRVAYV---NEGGALAHLYSWLKSSLTIELVPkkga----neslTPAVENNFTLLTRAEQ 596 Caenorhabditis ...
Q6PFS4       698 SIERGDLELAAKFVNQLRG-ESQ-----------RVAQDWLKEARLTLETKQVISLLsaYAN 747 zebrafish
Q55BP9       584 HLRKNNLSSAIKEMESIQQqSSKsstnidnhhlsKLTSNWIKQAKERDQLENISKLL--ELK 643 Dictyostelium discoideum AX4
Q2HCU4       614 FLEEGDLDNAAREMNGLTG-WSK-----------TLSRDWLGEVRKVLEVRQALEVIqtEAR 663 Chaetomium globosum CBS 148.51
Q5K8K8       669 CLAEKDLDGAAREINSLTG-WPA-----------KLANDWLQQARRKLEVQQALEVVatEAT 718 Cryptococcus neoformans
KIS72220     628 YLDRKDLDSATRELNQLKG-WPK-----------LLASDWLAASRKRLEVQQALDVVqtEAS 677
P91928       683 HVDRSDFLQALKYMNLLQG-ASR-----------KIAGEWMKEARLMLETQQAANTLmaHAA 732 fruit fly
1_pfamImport 642 WLDRGDLVKTVQYVNLLQG-APR-----------KAALDWLNEARLLLETQQAASTLmaHAA 691
DAA24582     681 CLEHGDLELAAKFVNQLKG-ESR-----------RAAQGWLKEARVTLETRQIVEILtaYAS 730
NP_001006462 652 CIEHGDLELAAKFVNQLRG-ESR-----------RVAHDWLTEARMTLETKQIVDILtaYAS 701
Q9XXN2       597 LWKSGKKSDAIRVLQLTDG-ATR-----------RVAADFIADARRQHEALLLSRLLlaHAA 646 Caenorhabditis elegans
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