Conserved Protein Domain Family
HkD_Daple
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cd22228: HkD_Daple 
Hook domain found in Daple (Dvl-associating protein with a high frequency of leucine residues) and similar proteins
Protein Daple, also called coiled-coil domain-containing protein 88C (CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling.
Links
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Statistics
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PSSM-Id: 411799
Aligned: 4 rows
Threshold Bit Score: 305.695
Created: 21-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative
Feature 1:putative LIC-binding interface [polypeptide binding site]
Evidence:
  • Comment:the conserved Hook domain interacts directly with the dynein light intermediate chain 1 (LIC1)
  • Comment:based on the structure evidence that Homo sapiens Hook 3 (6B9H) interacts with a dynein light intermediate.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
Q9P219         12 FLQSPLVTWVKTFGPFGsgsqdNLTMYMDLVDGIFLNQIMLQIDPrPTNQRINKHVNNDVnLRIQNLTILVRNIKTYYQE 91   human
P85120         12 FLESPLVTWVKTFGPCGnenesKLAMYMELVDGVFLNKIMVQIDPrPSNQRVNKHVNNDVnRRVQNLTILVRHIKAYYQE 91   African clawe...
A0A2R8QCI3     12 FMDSPLVVWVKTFGPLGfssedKLSMFMDLVDGVFLHKIMTHIDPsPMNQRVNKQVNNDVnLRIQNLNTVIRHIKNYYQE 91   zebrafish
XP_025007141   12 FLQSPLVTWVKTFGALGgggedKLGMYMELADGVLLNRIMLQIDPrPTNQRVNKHVNNDVyLRVQNLTILVRNIKTYYQE 91   chicken

Feature 1                                                 #     #  ## #    #  ## ##  ##  # 
Q9P219         92 VLQQLIVMNLPNVLMIGRDPLsGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTH 164  human
P85120         92 VLQQLIVMNLPNVLLISKDPLtDKSMEELKKILLLMLGCAVQCERKEEYIERIKQLDIETQAGIVSHIQEVTH 164  African clawed frog
A0A2R8QCI3     92 HLQQLIVMNLPNVLAIAKDPLsGKSMEEMKRMLLLILGCAVQCDRKEEIIEKIKLLDIETQAAIVTHIQEVTH 164  zebrafish
XP_025007141   92 VLQQLIVMNLPNVLMIGKDPLsGKSMEEIKKLLLLVLGCAVQCERKEEFIERIKQLDIETQAAIVSHIQEVTH 164  chicken

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