1WIX


Conserved Protein Domain Family
HkD_Hook1
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cd22225: HkD_Hook1 
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Hook domain found in protein Hook 1 (Hook1) and similar proteins
Hook1 is a microtubule-binding protein required for spermatid differentiation. It is a component of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex.
Links
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Statistics
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PSSM-Id: 411796
Aligned: 7 rows
Threshold Bit Score: 271.339
Created: 21-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative LIC-binding interface [polypeptide binding site]
Evidence:
  • Comment:the conserved Hook domain interacts directly with the dynein light intermediate chain 1 (LIC1)
  • Comment:based on the structure evidence that Homo sapiens Hook 3 (6B9H) interacts with a dynein light intermediate.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1WIX_A        10 LCDSLIIWLQTFKTAsPCQDVKQLTNGVTMAQVLHQIDVAWFSESWLSRIKDDVGDNWRIKASNLKKVLHGITSYYHEFL 89  house mouse
Q9UJC3        14 LCDSLMIWLQTFNTAsPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFL 93  human
Q5ZJ27        10 LCDSLILWLQTFNTAaPCRNVQDLTNGVAMAQVLHQIDVAWFDASWLNRIKEDVGDNWRIKSSNLKKILQGIMDYYHEFL 89  chicken
Q5TZ80         8 LCESLIIWLQTFKTAaPCKTVEDLTSGAAMSQALHQIDPSWFSESWLARIKEDVGDNVRLKMNNLKKILQMIVDYYNEVL 87  zebrafish
NP_001096450   8 LCESLIIWLQTFNTAaPCQTIQDLTNGVAMAQILHEIDYTWFDVSWLSRIKDDVGDNKRIKIHNLKKILQGIVDYYREFL 87  tropical clawed...
XP_007901877   8 LCDSLIIWLQTFHVSaPCENVQDLIRNSAMAQVLNQVDSSWFDDSWLSRIKDDVGDNSRLKMSNLKKILQMVLDYYQEVL 87  elephant shark
XP_014348001   8 LCESLVIWMQSFNTTtACKTVQDLTSGAAMAQALHQIDSSFFNETWLSRIKEDVHDNWRLKVCSINSTDLKLYFKKQNHT 87  coelacanth

Feature 1                                                         #     #  ## ##   #  ## ##  ##  
1WIX_A        90 gqqi--------------seeLIPDLNQITEcADPVELGRLLQLILGCAVNCEKKQEHIKNIMTLEESVQHVVMTAIQEL 155 house mouse
Q9UJC3        94 gqqi--------------seaLIPDLNQITEcSDPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQEL 159 human
Q5ZJ27        90 dqqi--------------seeLIPDLNKISEnSDPTELGRLMQLILGCAVNCERKQEHIQNIMTLEESVQHVVMTAIQEL 155 chicken
Q5TZ80        88 aqqm--------------sdfPLPDLMRVVEqSDQVELGRLLQLILGCAVKCDRKQEYIQIIMTLEESVQHVVMTAIQEL 153 zebrafish
NP_001096450  88 dqhi--------------lefLLPNLNLIADhSDATEMGRLLQLILGCAVNCEKKQEHIQVIMTLEESVQHVVMTAIQEL 153 tropical clawed...
XP_007901877  88 slqi--------------tdfPLPDLNTLVEqSDPLELGRLLQLILGCAVNCERKQEHIETIMTLEESVQHNVMTAIQEL 153 elephant shark
XP_014348001  88 eytlqgaplngdvlgqtildfPLPDLNRVAEhTDPLELGRLLQLILGCAVNCEKKHEYIQNIMTLEESVQHVVMTAIQEL 167 coelacanth

Feature 1        #   
1WIX_A       156 MSKS 159 house mouse
Q9UJC3       160 MSKE 163 human
Q5ZJ27       156 MSKE 159 chicken
Q5TZ80       154 MSRE 157 zebrafish
NP_001096450 154 MSKD 157 tropical clawed frog
XP_007901877 154 MSKE 157 elephant shark
XP_014348001 168 MNKE 171 coelacanth

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