Conserved Protein Domain Family
Syt2_N
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cd21964: Syt2_N 
N-terminal domain of synaptotagmin-2 (Syt2) and similar proteins
Syt2, also called synaptotagmin II (SytII), exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. It may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It plays a role in dendrite formation by melanocytes. The model corresponds to N-terminal domain of Syt2, which is a recognition domain responsible for the binding of botulinum neurotoxin B (BoNT B).
Links
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Statistics
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PSSM-Id: 409249
Aligned: 7 rows
Threshold Bit Score: 67.8895
Created: 17-Jun-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Botolinum
Feature 1:Botolinum neurotoxin B binding site [polypeptide binding site]
Evidence:
  • Comment:based on structure 4KBB, Mus musculus Syt-2 interacts with botulinum neurotoxin B (BoNT B)
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                     #  ## ### ##                       
Q8N9I0         4 IFKRNQEp--iVAPATTTATMPig---pvDNSTEsggagesqEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLT 78  human
XP_018104734   5 LFKKAEApl-pETHTMMTSTEPsvv--sqDNSTAvagsgdksADTFRKIQQELMNQINKIPLPPWALIAIAVVAGLLIIT 81  Xenopus laevis
XP_007892400   3 LGETNSEa--lAAPISSTTMIPvg---pgDNSTEsgghaagkNDVFEKLKDKFMNELNKIPLPPWALIAIAVVGGLLILT 77  Callorhinchus m...
XP_028652822   7 LFPHHTA----VPEPNSTAVTPsvs-saaDNSTEpv----nsSNQYTTIFKQLGVVFKKIPLPQWAIIALAVVVGLLVIT 77  reedfish
XP_005995512 142 LLKKNPEp--mVAPVPITTVMPiv---stENVTEpmgpeesnEDMFAKLKEKFMNELNKIPLPPWALIAIAVVAGLLVLT 216 coelacanth
XP_003642761   2 TFKQASM----MAPEATATTMPma---tmENSTEaagtgeskEDMFADLREKFMNELNKIPLPPWALIAIAVVAGLLLLT 74  Gallus gallus
TSM36106       2 VGPEPTGlggtHLPSTMTMAPGpavstaaDNSTGagg--ssmDEIFEKIRNKFFNEIETIPLPPWALIAIAVVAALLIVT 79  goonch

Feature 1                                               
Q8N9I0        79 CCFCICKKCCCKKKKNKKEKGKG----MKNAMNMKDMKG 113 human
XP_018104734  82 CCFCICKKCCCKKKKGKKEKGKGkgkgMKNALNMKNMKG 120 Xenopus laevis
XP_007892400  78 CCLCICKKCCCKKKKNKKEKGKG----MKNAINMKDVKN 112 Callorhinchus milii
XP_028652822  78 CCFCICKKCCCKKKKNKKEKGKG----MKGALNLKNMKG 112 reedfish
XP_005995512 217 CCFCICKKCCCKKKKNKKEKGKG----MKNAMNMKDMKN 251 coelacanth
XP_003642761  75 CCFCICKKCCCKKKKNKKEKGKG----MKNAMNMKDMKS 109 Gallus gallus
TSM36106      80 CCFCIIKKCCCKKKKNKKGKKGKdgfnMKNMQGGDKQQD 118 goonch

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