Conserved Protein Domain Family
Syt1_2_N
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cd21342: Syt1_2_N 
N-terminal domain of synaptotagmin-1 and -2
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse. In general, synaptotagmins contain 2 calcium binding C2 domains. Synaptotagmin-1 and -2 have an additional N-terminal domain that has been shown to bind to Botulinum neurotoxin B.
Links
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Statistics
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PSSM-Id: 409247
Aligned: 11 rows
Threshold Bit Score: 59.3671
Created: 23-Dec-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Botolinum
Feature 1:Botolinum neurotoxin B binding site [polypeptide binding site]
Evidence:
  • Comment:based on structure 4KBB, Mus musculus Syt-2 interacts with botulinum neurotoxin B (BoNT B)
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                  #  ## ### ##                          
P21579        11 AAPPVTTVATvl--psNATEpasp-----------gegkEDAFSKLKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCF 77  human
OCT70762      10 VASQQTTFPPel--hhNGTEmp---------------tkHNVFSDMKNKFMNELSKLPIPPWALATIIIVAGLLLLCCCF 72  African clawed ...
XP_007908043   9 MVLSTVTAPPel--lpNVSEtp---------------skHNVFSHMKHKFMNELSKIPIPPWALAAIIILVGVLLVCCCF 71  elephant shark
TFJ95941       8 AMLATEVTAPptepalNATEtp---------------skENVFSDMKDKFMNKLSKLPIPPWAVATILLVAALLLLCCCV 72  big-headed turtle
XP_028929923   9 MVATQLPATPsgl-phNGTQtp---------------rkEDVFAHMKDKFMNRLSKLPVPPWALATILILAGLLLLCCCV 72  platypus
XP_008281724   7 AAPSTSSVPTnl---pNATAtp---------------gqKQSGGQSPNKFMNELHHIHMPSWAVAALCIVSLCVVLSCAV 68  bicolor damselfish
ROL23553       9 AGPSLSPASPa----qNGSKvpgptsspp--tavqtttaESLAHSIRSKFMNELHKVPLPSWALVAFGFLVVLIISSCCL 82  Anabarilius gra...
XP_017553728  11 PLLPGSATPTqk---lNGSKalrptevlptgappqatpgESFISSFRSKFLNELHKVHLPSWALVTLGFIIVLLILSCCF 87  red-bellied pir...
XP_027884643   5 AAPSTSFSPTki---pNAATtp---------------gkNQTGSQGANKFMNELRSIHKPSWATAALCIVILCMVLSCVL 66  Monterrey platy...
XP_022111830  27 KGVVSVTGVPa-----GVTEgt---------------kgGTVLNKFGDKIMEELQKLPLPMWAIILIAIVAGLLLLCCCG 86  crown-of-thorns...
Q8N9I0        14 APATTTATMPigp-vdNSTEsgga-----------gesqEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCF 81  human

Feature 1                                        
P21579        78 CICKKCLFKKKNKKKGKEkggkNAINMKDVKD 109 human
OCT70762      73 CICKKCCGKKKKGKKGKDkv-kAQINMKEVKD 103 African clawed frog
XP_007908043  72 CVFKKCCNKKKKKKGKDKg--kAQINMKGVKD 101 elephant shark
TFJ95941      73 CACKKCGKRKKGKKGKDKa--kAQINLKEVKE 102 big-headed turtle
XP_028929923  73 CICKKCCGRKKGKKAKGK----AQIHLKEVKE 100 platypus
XP_008281724  69 CVWKKCLKKKDKDKEKEKd--kKQGKEKSKGG 98  bicolor damselfish
ROL23553      83 CFCRKMIFKKKKEKGGKEknekNTINMSSVRE 114 Anabarilius grahami
XP_017553728  88 CICRKFVFKKKKEKAGKEksgkDSISMSTMRE 119 red-bellied piranha
XP_027884643  67 CIWKKCLIKKDKDKEKDKk--kGKEKIKGGFD 96  Monterrey platyfish
XP_022111830  87 CICVKCCCKKKKKKEGKKgl-kGAVDLKSVQM 117 crown-of-thorns starfish
Q8N9I0        82 CICKKCCCKKKKNKKEKGkgmkNAMNMKDMKG 113 human

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