Conserved Protein Domain Family
CLP1_P
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pfam16575: CLP1_P (this model, PSSM-Id:406878 is obsolete and has been replaced by 406878)
mRNA cleavage and polyadenylation factor CLP1 P-loop
CLP1_P is the P-loop carrying domain of Clp1 mRNA cleavage and polyadenylation factor, Clp1, proteins in eukaryotes. Clp1 is essential for 3'-end processing of mRNAs. This region carries the P-loop suggesting it is the region that binds adenine or guanine nucleotide.
Links
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Statistics
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PSSM-Id: 406878
Aligned: 76 rows
Threshold Bit Score: 108.882
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4Q752        130 GENQWEREAVSRALLNLAVRHGSpyGICYVDLDVAMPMVGCPGTVSAAFVEEPV---TAPEDFGVMmpL--TFFH-GTAS 203 Leishmania major
WP_013706228   33 GGPDRGKSTFCRYLLGRARAESR--PAAFIDGDLGQSHLGPPATLGLNFYPPRP---PDDSGLFPD--V--LYFI-GQTS 102 Desulfobacca a...
EHO42103       27 GNTDCGKTTLSRFLVQE-LAQIE--KVAWIDCDPGQSNLGLPTTLNAGIYDASL---SS-----PQhvF--SRFI-GVTT 92 
WP_013032124   29 GATDRGKSTYCAFLGQTLSAAGF--RVAFVDADVGQKDVGPPATISLAYLDEAL---EL-----SQapLaaLYFV-GAVS 97  Nitrosococcus ...
jgi:Gura_3491  41 GATDSGKSTLARFLVAGLTATGL--TVALVDTDVGQSALCLPGTVGVKLFRSSA---DLADYRCEQf-----sFL-GSAN 109
Q8TZ62         44 GPQDSGKTTLVTFIANELVERGL--KVGIVDADVGQSDVGPPAVVSLGIVEDTV---HD--LSEVEmrH--GYFV-GSIT 113 Methanopyrus k...
jgi:Tpen_0195  96 GGVDSGKTSFVTFLANRLSQAGE--RVGIVDADLGQKSIGPPATIGLGVVASPLvslGEAEFV-----D--GFFV-GSVT 165
Q5JDN6         34 GGVDSGKSTLITFLGNELLSLGF--KVAVVDSDVGQKGVLPPGTISLAIPEGPF---ESMSELEGVa----HYFV-GTTA 103 Thermococcus k...
Q58711         39 GGVDSGKTTLATFLANELLNLGF--KVAIVDSDVGQKSILPPATISLAFPETNF---NN---LYEIkpY--KSYFvGSTA 108 Methanocaldoco...
Q8U4H6         36 GDVDTGKTTLIVYLANELISRGF--KVAIVDADVGQKGILPPATISLALADMKF---SS---LSELkpL--IHYFvGSIT 105 Pyrococcus fur...

Q4Q752        204 VTSATRkRYLDLCVCAAQAATslgfansKFEAGGFLIHSLSPSTEI-Q-HDVL-SDVLSIFAVTHVVVTGAdRELEKFLY 280 Leishmania major
WP_013706228  103 PPGRMM-ELVVGLRHLADIAR-------RRGQYRIIVNTSGFIGGP-A-AHRLkLAKAESLTPRLVIGLQQ-EQELASIL 171 Desulfobacca a...
EHO42103       93 PQRKPLlSLLSIVRLHARVVEq--------GAKFTIMDSSGYSAGP-AaVEFQ-AAIIEAIKPDLVILVER-EQELEALN 161
WP_013032124   98 PIGHL----LPVVVGTKRMVE-------LAQAPFVIIDTSGLVTGS-G-RVLK-TFQIDSLRPQVIVALEK-EQELGPIV 162 Nitrosococcus ...
jgi:Gura_3491 110 PA--------RLVPRLLETTGrlt-elaRSRAEVVLIDTTGLISGElG-RGLK-LAKIRVTLPDQIIALQR-RDECEPIL 177
Q8TZ62        114 PSGHLL-QTTVGTRRMVDLALa-------eGTDVVLIDTSGMVHGG-P-ARALkLHKVDAIRPSHVAFLDR-DGQVSHIK 182 Methanopyrus k...
jgi:Tpen_0195 166 PSGLLH-RHVVGVRLMVEVAEt------RMGVRRVVVDTTGWVSEQ-G-GRELkLFKAMALEPDVVVVVSRgDECLHIV- 235
Q5JDN6        104 PSQ--------FIGEMAVGVKrmv-eiaRNVADVVLIDTTGFVTGV-G-AEMK-RLKAELVKPDIIAVIHS-GELSGLVK 170 Thermococcus k...
Q58711        109 P--------IQFFGEMITGTKllc-dyaEDKADIIIVDTTGLISGS-G-ADLK-RMKIEMIKPDIIIALEKrNELKSILK 176 Methanocaldoco...
Q8U4H6        106 PSQ--------FFGEMIVGTMrlseigkK-FADYVLIDTTGMIYGS-G-VELK-RLKIEAVKPDLILALEK-KEELNPIV 172 Pyrococcus fur...

Q4Q752        281 NAVL-GRTVHFVRLPKLAGVQSPSSAGAEQRRRAQLERYFF 320 Leishmania major
WP_013706228  172 APLQrFRPEAVLTLPVSAQAQPKPFQQRRLYRQERFAAYFQ 212 Desulfobacca acetoxidans
EHO42103      162 QHVGrLGGIELKRIPVSQYVTPRSMPIRKEYRENKFREYFQ 202
WP_013032124  163 RACR---NYNVIRLRSSPQTKAKSIDIRRAAREQAFRTYFE 200 Nitrosococcus halophilus
jgi:Gura_3491 178 GQLD---ELVIRRIHPHPAARTRSKESRSRIRRERLAAYFA 215
Q8TZ62        183 RMVKsLKYIKVHDLAVPDAVKDVERKDRIRRRERVLREFFE 223 Methanopyrus kandleri
jgi:Tpen_0195 236 NTLG--RLFEVVQVEAPKAVRLRGRIDRREYRKVMYRKFFE 274
Q5JDN6        171 ALEP---YGGVIELAVSETVKRYPLEERRNLRAEKWRNYFR 208 Thermococcus kodakarensis KOD1
Q58711        177 -PFE--NKIRVFYLKVYENAKSFSREERKEIRAEKWKEYFK 214 Methanocaldococcus jannaschii DSM 2661
Q8U4H6        173 SGFE-DKTIKLKVSENARSY---SRSERRQIRQEKWRKYFE 209 Pyrococcus furiosus DSM 3638
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