6DWO,2WW2,6F90


Conserved Protein Domain Family
Glyco_hydro_92
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pfam07971: Glyco_hydro_92 (this model, PSSM-Id:400362 is obsolete and has been replaced by 429762)
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Glycosyl hydrolase family 92
Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation.
Links
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Statistics
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PSSM-Id: 400362
Aligned: 654 rows
Threshold Bit Score: 365.266
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6DWO_D       223 QAQLNLAREI--SlRSTEMLQQGIADWHNYFDRLKVTH---ENPEHTKTFYHTLYRTFLFPQTFYEldeNqqp------- 290 Enterococcus fa...
ESK91898     255 RACSNAEEEIpdW-NWDQVQKDAKAKWEDALQRVQLDNidqEDATVVELLYSSLYRTSLVPANLTG---Enpyws----- 325 Moniliophthora ...
KEI37084     273 QACANADQEIgqD-DFDTVLSKSRALWNEKLSRLEVDVd-kTSINVTKMLYSSSYRSFLTPSNATG---Ervgrfad--p 345 Mixia osmundae ...
EJT74764     301 KACENLEAEIpaApDFDRLVADSNGLWEEKLGRIELAEg--TPDYMRRLFYTNFYRTFLSPNNATG---Dapppyt---- 371 Gaeumannomyces ...
XP_007856025 304 RACANLDSEVgsS-SFKDIVSKSKALWNDKLRKIELDIp-nTPENVVEMFYSSLYRSNLTPNNATD---Eaqgtysagya 378 Moniliophthora ...
XP_007848586 310 QACANAESEVgsS-SFEDIVAKSKVLWNERLSKIEIDIa-nTAENVTEMFYSSLYRASLTPNNATG---Eaqgafl---- 380 Moniliophthora ...
EMD37640     311 QACSNAETEVgdS-SFEDIMAQSKALWNEKLSKVEIDFa-qTAPNVTEMLYSSLYRSFLTPNNATN---Etqaefa---- 381 Gelatoporia sub...
XP_007396902 310 QACANAESEVgdS-SFEDIVAQSVALWNEKLSKIEIDLa-hTPPNVTEMFYSSLYRAFLTPNNATG---Etqgpfa---- 380 Phanerochaete c...
EGN99935     310 QACQNAESEVgtT-SFDGIVNASKALWNEKLSKIEIDVp-nTPPNVTEMFYTSLYRASLTPNNATS---Etqgvfa---- 380 Serpula lacryma...
EFJ03492     308 QACANAEEEIgeK-SFEDVWAEARGLWNEKLSRIEIDVg-gTPANVTEMLYSALYRSNLTPNNATG---Etqgkyv---- 378 Schizophyllum c...

6DWO_D       291 ---ihYDtfSQTvrpgvlY-TnngfWDTYKTVYPLFSLIAQEKYEEMLEGFLNSYN-EtGFLPKWLSPD-ERGLMPGTLI 364 Enterococcus fa...
ESK91898     326 -spypFY--DAL------FcS----WDTFRTVHPWLSLTSPREWAEIVNAYVDGWRhT-GYIPECRANTkAGYVQGGSNG 391 Moniliophthora ...
KEI37084     346 psnrpFF--DDI------YtS----WDTFRTATPWLSLHSPQDLGELVGTYLDGFQrF-GYIEDARGEQlPGYAQGGSDA 412 Mixia osmundae ...
EJT74764     372 dsahpYF--DGL------YcS----WDTYRTLFPLMALTSPRDMAHITDSYVDGWRrE-GWLPECRANNvKGWVQGGNNG 438 Gaeumannomyces ...
XP_007856025 379 ntthpYY--DSL------YcS----WDTYRTFFPLLSLTSPVEFAQIVDAYLDGWRtE-GWMPECRANNlPGWSQGGSSA 445 Moniliophthora ...
XP_007848586 381 gtssyYF--DSL------YcS----WDTFRTFFPFMSLHSPVEYAQIVDTYIDGWRkL-GWMPECRANNlPGWTQGGSSG 447 Moniliophthora ...
EMD37640     382 ntthfYF--DSL------YcS----WDTFRTFYPLMSLHSPVEFAQIVDNYIDGYLkR-GWMPECRANNlPGWTQGGSSG 448 Gelatoporia sub...
XP_007396902 381 gtthhYF--DSL------YcS----WDTFRTFYPLMALTSPVEFSQIVDNYLDAWRvL-GWMPECRANHlPGWTQGGSSG 447 Phanerochaete c...
EGN99935     381 nttsfYF--DSL------YcS----WDTFRTFYPLMTLHSPVEFAQIVDNYIDGWRkN-GWMPECRANNlPGWTQGGSSG 447 Serpula lacryma...
EFJ03492     379 gttsqYF--DSF------YaS----WDTYRTFYPLMALTSPVEFAQIVDSYIDGWRkE-GWLPETRANNlPGWTQGGSSA 445 Schizophyllum c...

6DWO_D       365 DAVIADAAVKk-iR------PDLmpQFLEAMKKGATqqserenYG-----RQGTLDYlKYGYVPS---------T-YhES 422 Enterococcus fa...
ESK91898     392 MPILGDFAVKygsRaeelgvPIE--DLYQALVDTAEnt----pPDwy-rvGRQNTAWkTFGFIPTdwvdpsgstGlAtRE 464 Moniliophthora ...
KEI37084     413 EPILSDWVVKy-gSsf--svDGQ--EVMSALDADATnt----pKQwiaggGRENDLYeQYGYIPTnalv-dgnsGvQtRQ 482 Mixia osmundae ...
EJT74764     439 VPVVADFVVKygaRaaelgvSMD--DYWAALEHDVDat----pANwd-yeGRNNEAYnRLGYIPYdfle-rdavGqHtRE 510 Gaeumannomyces ...
XP_007856025 446 DNIVSHFALAyhnEaqrlgiNLD--ELYSALLADGDen----pPNwy-tvGRQINVYkQYGYVPYdsqd--psaGiRtRE 516 Moniliophthora ...
XP_007848586 448 DNIVSHFAIYyhnEaerlgiNLE--ELYSALLADGDin----pPEwn-tlGRQVNVYkQYGYVPFavld-ptstGrQtRE 519 Moniliophthora ...
EMD37640     449 DVIVGHFAMTyhnEaselgiDLE--QLYAAMIADGEvn----pPEwn-iqGRQVNVYkEFGYVPFavld-tmstGrQtRE 520 Gelatoporia sub...
XP_007396902 448 DVIVGHFAMTyhdEaaalgiNLN--DIYSAQLADAQlt----pPNwd-ieGREAGAYiKYGYVPAsvle-tdsvGrQtRE 519 Phanerochaete c...
EGN99935     448 DNIVSQFAINyhnEaqalgvDLN--ELYAALKTDGEvn----pPEwn-ieGRQINVYkQNGYVPFavld-tastGrQtRE 519 Serpula lacryma...
EFJ03492     446 DNILSHFAVHyhnEaaalgiDLE--ELYAAVLTNGEkn----pPEwn-iyGRQINVYkQYGYVPAgvld-tssvGrQtRE 517 Schizophyllum c...

6DWO_D       423 VNHTLDYAYSDFCISQVAKTLND-SETATFYRQQALNYQQLFNPE------TGFMQAKDTEGNFRpdFldiRW------- 488 Enterococcus fa...
ESK91898     465 ASRAYEYALGDFAVRQTAITLGKsTEEVDKYTNRSMNFVNMWDPNlvhdgfKGFAQRRYPNGTFA--F---SPpdacspv 539 Moniliophthora ...
KEI37084     483 VSRTLEYAFNDFTVATAARAQGN-PDRADFYFQRSLYYRNVF-VNasfdgfTGFAQQRLPNGSFI--L---RDpricspl 555 Mixia osmundae ...
EJT74764     511 FSRGLEYSFGDFAAAMAARALGKsPNVWRPLLDRSLGYSANYNMAlesdgfRGFVARRLANGTFL--P---SDptdcspl 585 Gaeumannomyces ...
XP_007856025 517 ASRTPEYAFEDFGIRQVALLLGK-AEDEARYANRSLNYRNVWDPSvqsdgyQGFMQKRYRDGRFQ--Y---TDpvwcspr 590 Moniliophthora ...
XP_007848586 520 GSRTLEYVFEDFGIRQVALLLGK-TEDEARYANRSLFYRNIWDDSiesdgfKGFMQKRFPNGTFA--F---QDpkncspq 593 Moniliophthora ...
EMD37640     521 GSRTLEYAFEDFAIRQVALLLNK-TDDVETYTNRSFFYRNVFDPNvksdgfTGFSQKRFMNGSFA--Y---VDpidcspl 594 Gelatoporia sub...
XP_007396902 520 GSRTLEYAFEDFAIRNVALLLNK-TEDFETFNNRSQSYRSVWDSNvksdsfAGFMQKRFPNGTFL--Y---TNpvdcspi 593 Phanerochaete c...
EGN99935     520 GSRTLEYAFEDFGIRQVALLLNQ-TDDVAEYTNRSYFYRNVWDKDvtsngfQGFAQKRLSNGTFV--Y---TDpidcssq 593 Serpula lacryma...
EFJ03492     518 GSRTLEYAFEDFGIRQVAQLLGH-DEDLAEYTNRSYWYRNVWDPSvesdgfKGFPQKRLPNGDFN--Y---TDpihcslk 591 Schizophyllum c...

6DWO_D       489 --------------GKdyA-EGSAWQSSFAVYQDFAGLIKLYG-SELA-FEKKLIQLCnQapnfnvegygfeihemsema 551 Enterococcus fa...
ESK91898     540 dpi-ghscargtdnNVg-FyESSSWEMSFFAPHSVATLIRLMG-GNET-FVQRVDHYF-S-------------------- 594 Moniliophthora ...
KEI37084     556 dtnatrscslqqgtSDg-FyEASSWEYSFFAPHDMAGLIDLTAqGNRTeFIRRLDYFF-D-------------------- 613 Mixia osmundae ...
EJT74764     586 dknatrpcslqstnVYg-GhESSSWEYSFYAPHDGAGLVRLLG-GNDT-FAARLRRFF-G-------------------- 641 Gaeumannomyces ...
XP_007856025 591 dtg-srscslqndnDSg-FyESSSWEYSFMAQQDVAGLITLMG-GPEM-FVKRLDHLF-E-------------------- 645 Moniliophthora ...
XP_007848586 594 dkndtrpcslqgnnVNg-FyESSSWEYSFYAPHDTVGLIDLMG-GNDT-FVKRLDHFF-D-------------------- 649 Moniliophthora ...
EMD37640     595 dns-trdcslqddnSVg-FyEASSWEYSFFVPHDTAHLIQLMG-GNET-YVNRLDHFF-S-------------------- 649 Gelatoporia sub...
XP_007396902 594 dns-srscslqddnTVg-FyESSSWEYSWFVPHDTAHLIELMG-GNET-FVNRLDHFF-E-------------------- 648 Phanerochaete c...
EGN99935     594 dtnqsrscslqednIVg-FyESSSWEYSWYAPHDTAYLIELMG-GNDT-FVKRLDYFF-N-------------------- 649 Serpula lacryma...
EFJ03492     592 ddnsnrecsltagnTNg-FyESSSWEYAWFVPHDTAYLIELMG-GNET-FVDRLDHFF-E-------------------- 647 Schizophyllum c...

6DWO_D       552 aidFGQLAISNQPSFHYPFLFSYIGKPEMAQPLLKQLM-QTFDASPTGYPGDEDNgSMSAWYIFNSLGFYPVtPGTGEYV 630 Enterococcus fa...
ESK91898     595 ---KGYFQAGNEPSFAIPWIYHYANRPDLTASRVRQIVyKNFNTGIGGIPGNDDSgAMAALLTFHLLGLYPV-PGTKQLL 670 Moniliophthora ...
KEI37084     614 ---QGLFDPSNEPSFATPLAYHYVDRPDLSIKAVRKIVaQSFGIGKDGLPGNDDQaAMATLLIFHLLGMFPV-PGTTQML 689 Mixia osmundae ...
EJT74764     642 ---AGYNVVGNEPSFQTPSLYHHVGLPGSSVRESRRVVlDNFNLTRGGSPGNDDNaAMSSLVVWYMLGLYPV-PASAEML 717 Gaeumannomyces ...
XP_007856025 646 ---GGYYLPGNEPSFHTPAQYHYANQPTKSVDRVRDVVfSNFDITPGGIPGNDDQgAMASLLIWHLLGLYPI-PSTTQIL 721 Moniliophthora ...
XP_007848586 650 ---AGYYLAGNEPSFQTPIGYHYANQPAKSVDRVREVVfTNFDITAAGLPGNDDQaAMATLLAFHLLGLYPV-PSTSHLL 725 Moniliophthora ...
EMD37640     650 ---AGLFDPSNEPSFQTPIGYHYANQPTKSVDEVRNLVfTSFDITPAGIPGNDDQaAMATWLVFHLLGMYPV-PSSSQFL 725 Gelatoporia sub...
XP_007396902 649 ---KGYYYAGNEPSFQTPIGYHYANHPTQSVDRVRDVVfTNFDITPAGIPGNDDQaAMATLLAFHLLGLYPV-PGSTELL 724 Phanerochaete c...
EGN99935     650 ---EGYYLPGNEPSFQTPIGYHYANQPADSVDRIRDVVlTNFDITPAGLPGNDDQaAMATLLCFHLLGLYPV-PSTSHYL 725 Serpula lacryma...
EFJ03492     648 ---AGYYLAENEPSFQTPIGYHYADRPTKSVDRVREVVfENFGITPAGLPGNDDQaAMSSLLTFHILGLYPV-PSTTELL 723 Schizophyllum c...

6DWO_D       631 IGMPLVQTAEVKL-SNGKQLTIqtSpN---------------KvqQqFIHEIQLNQEKH--TApYFTH----QellNGGT 688 Enterococcus fa...
ESK91898     671 IGSPFVSSFTLKNnVFDTETKF--TvTgfdqatltgtppsgsR--L-FVKSVTINGEPSpsLC-VIDFdv-vV---GGGD 740 Moniliophthora ...
KEI37084     690 LGSPSLPSFNITNaGTNSKATF--SvTgydprtlmnpppvdaK--L-YVRSITINGQAQpsTC-FVDFrdvfV---KNST 760 Mixia osmundae ...
EJT74764     718 VLSPFLPGYTVHNeLLG-DVRV--TvTgfdpaslnstipagaR--A-FVDDLRLDGK-SvgRC-RVDFdq-fF---SARN 785 Gaeumannomyces ...
XP_007856025 722 VISPFIPKYTIHNdYLGKSTTV--TvKgydrnsvqksipqgaA--A-YVKSVTINGKPSfsRC-HIDFydvfR---VGGD 792 Moniliophthora ...
XP_007848586 726 ILSPFTPKYTIHNsFLNSSTTV--TvKgfdpnsvqkvipdgaA--A-YVKNVMINGKPSesRC-HFDFydvfR---LGGE 796 Moniliophthora ...
EMD37640     726 VVSPFLPKYTIHNsFLNVSTTV--TvQnfdprsvqktiphgaA--A-YVKSVTVNGNVQpsRC-HIDFydvfR---VGGE 796 Gelatoporia sub...
XP_007396902 725 VVSPFIPQYTVHNsYLNVSTTV--TtKgfdarsvqqtipkgaA--A-YVANVTINNQLLasRC-HLDFydifK---TGGD 795 Phanerochaete c...
EGN99935     726 ITSSFIPKYTIHNsYLNTSTTI--TvQgydaksvqspipsgvA--A-YVKNVTVNGQVTasRC-YVDFydtfR---LGGN 796 Serpula lacryma...
EFJ03492     724 ILSPFVPKYTIHNaYLNVSTTV--TvAnfdpksvaqtipdgvA--A-YVESVAINGEELpsRC-HLDFydafR---LGGN 794 Schizophyllum c...

6DWO_D       689 LDYQLGI 695 Enterococcus faecalis V583
ESK91898     741 IVIQVDG 747 Moniliophthora roreri MCA 2997
KEI37084     761 IVIELTA 767 Mixia osmundae IAM 14324
EJT74764     786 VEFVMTA 792 Gaeumannomyces tritici R3-111a-1
XP_007856025 793 VVIEVTA 799 Moniliophthora roreri MCA 2997
XP_007848586 797 VEIEVTA 803 Moniliophthora roreri MCA 2997
EMD37640     797 VVIEVTS 803 Gelatoporia subvermispora B
XP_007396902 796 IVIEVTA 802 Phanerochaete carnosa HHB-10118-sp
EGN99935     797 IVIELTS 803 Serpula lacrymans var. lacrymans S7.3
EFJ03492     795 ITITLTA 801 Schizophyllum commune H4-8
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