3AFL,4FNV,4MMH,5JMD,4NEI


Conserved Protein Domain Family
Hepar_II_III

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pfam07940: Hepar_II_III (this model, PSSM-Id:400338 is obsolete and has been replaced by 429747)
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Heparinase II/III-like protein
This family features sequences that are similar to a region of the Flavobacterium heparinum proteins heparinase II and heparinase III. The former is known to degrade heparin and heparin sulphate, whereas the latter predominantly degrades heparin sulphate. Both are secreted into the periplasmic space upon induction with heparin.
Statistics
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PSSM-Id: 400338
Aligned: 70 rows
Threshold Bit Score: 75.9108
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3AFL_A       490 ADLPALAVFDDIGW-ATIQKdmedpdRH-LQFVFKSSPYGS---LSASHGDQNAFVLYAHGEDLAIQSG---YYVAFN-- 559 Agrobacterium f...
Q220X2       352 NPVTGSNLFPVAGYaIWWQA------NEsKQLSQTLIAWAKhdgHGHKHADEGSVLFWSGGVDWLTNTG---YWPYGAr- 421 Rhodoferax ferr...
Q5V5W9       368 PVPSHSPMGGETGY-YWLDT------DH-GQLLVDGGPVGPsnlPGHSHNDMLSVLLWVDGQRVLTDTG---VYDYAD-- 434 Haloarcula mari...
Q81K28       308 APTEDDKVFPKSGY-AIFRNdwskeeKA-TYVLFTAAYHV----DYHKHSDDLNLYIYSNGE-IITEAG---PNGYNY-- 375 Bacillus anthracis
Q02D12       365 PPVDTSHAFRWAGY-YVMRSgw--daDA-RYLWFDGGPFG----YGHQHEDKLQIVVEAYGKLLLVDPG---NYTYER-- 431 Candidatus Soli...
EAY04736     136 GRGTCPVFLAKTNW-TK---------GNgFYLAMKGGSSN----LSHSHQDAGSFIFEANGVRWASDLGiqdYDQLNRdg 201 Trichomonas vag...
Q5LIC3       400 HLTPPFSWYPETEF-CYITD------NKgNFLAAKGGYND----ESHNHNDAGTFSFWIDQTPFLIDAG---VGTYTRqt 465 Bacteroides fra...
Q2YCG2       490 PPRANSIAFHDIGW-VAMHSaivdplR--TSVYFRSSPYAA---FGHSHADNNSFVLVSRDEPLLIASG---YYDWEG-- 558 Nitrosospira mu...
4NEI_A       375 ILLGDGADGDQGAL-SIHRLge--ghNH-MALVAKNTSQG----MGHGHFDKLNWLLYDNGNEIVTDYG---AARYLNve 443 Saccharophagus ...
WP_015481708 397 MMLSDGSKGDEGGI-GILRYnn---kDEtMALVYKYAAQG----LSHGHYDKLSFSLYENGDEVLQDYG---LSRFVNve 465 Polaribacter sp...
3AFL_A       560 ---------SQmHLNWRRQTRSKNAVLIGGK-GQYaekdKALA---RRAAGRIVSVEEQ-----PGHVRIVgD---ATAA 618 Agrobacterium f...
Q220X2       422 --------nEEaAYSWTGSNAPH----------------QPGE---EFLVPRSVQLLKTg---eASGVSFIeVerrNTDG 471 Rhodoferax ferr...
Q5V5W9       435 ---------NE-RRQYARSVAGHNTVQVGET-EPI----EIGG---KYLMGARTEPTAEy---eGADPTLFrG---HYET 490 Haloarcula mari...
Q81K28       376 ---------KDpFTEYAYSSFAHNTLIVDGK-GLP----RTDR---QYEKVYLSDYEIN-----KDKVEATgI----NLR 429 Bacillus anthracis
Q02D12       432 ---------SK-WRSYFIDSPSHNVVLVDGE-AQR----RRGAprdTYVIKEPLPAVWKs---aPDTDYVEaT---FDEN 490 Candidatus Soli...
EAY04736     202 vkisnfgqqSErWTVFRFMSIGHNTLTVDND---------------LHNVAGYVGFTQT-----FEDDNKLgGqmnMVDL 261 Trichomonas vag...
Q5LIC3       466 -------fsKDrYTIWTMQSNYHNLPLINGV-PQR-----------YGATYKATQVQAD-----KRKNTFTaN---IATA 518 Bacteroides fra...
Q2YCG2       559 ---------SPhWKQWYWQTKAHNAITFDGGkGQA----EKTG---SGKMTAKGQLTEFq---sNGKVDFTeGd--ATPA 617 Nitrosospira mu...
4NEI_A       444 aky-gghylAE-NNTWAKQTIAHNTLVVNEQ-S------HFYG---DVTTADLHHPEVLsfysgED-YQLSsAk--EANA 508 Saccharophagus ...
WP_015481708 466 qkn-gggylKE-NKTYAKHTIAHNTVVQNGV-SHYk--yDFET---GSKNHPEQFIFDAt---dAKFQIVSaK---ESNA 531 Polaribacter sp...
3AFL_A       619 YqvANPLVQKVlre-------thfVND--SYFVIVDEVECSEPQE--------------LQWLCHT-LgaPQT------- 667 Agrobacterium f...
Q220X2       472 AqfRRQVLQIDaqtllvldfaqgvPKGieTIWTVDPTLRLSPGATasnfistpvpdgrhLMISYTN-H--TAVrvqirrg 548 Rhodoferax ferr...
Q5V5W9       491 Aa-AAPASYRHdrt--------ilASD--DWWLVRDELRGPDTETe------------pSVSRLHF-H--PEVav----- 539 Haloarcula mari...
Q81K28       430 Y-----TGVEHsrtv------symKDE--EKIVVKDLVKSDKRHE--------------YKLLWHV-A--SDItvhvrd- 478 Bacillus anthracis
Q02D12       491 FggEVKRNVTHtra-------vlfVKP--DFWVVLDTLTAKDGKPh------------mYDALFHFda------------ 537 Candidatus Soli...
EAY04736     262 F--FGKLSKSLrtv--------llLNN--EYLEVTDDIVCGDTA---------------VLVTWTMiT--PTSda----- 307 Trichomonas vag...
Q5LIC3       519 Yp-AEAEVESWirs--------ysLQK--GQLRISDSFRLTTAKQp-------------NQINFMT-W--GQVn------ 565 Bacteroides fra...
Q2YCG2       618 Y--EGALQQARrrl-------wylRNK--NVLIIHDSLRSATPRQ--------------FEWNIHAlN--PFEikepgs- 669 Nitrosospira mu...
4NEI_A       509 Y-----DGVEFvrsm-----llvnVPSl-EHPIVVDVLNVSADKAstfdlpl-yfngqiIDFSFKV-KdnKNVmk----- 570 Saccharophagus ...
WP_015481708 532 Y-----PGTEMhrtl-----imikDDAl-EKPFIVDVFNLQSNSKn------------qYDLPFHY-F--GQIiatsfdy 585 Polaribacter sp...
3AFL_A       668 -----------------------GrSSFRY---------------NGRKAGfygQF-------------VYSSGGTpqis 696 Agrobacterium f...
Q220X2       549 ser-----------pfagwvvvdG-RPTQAdal----------qiVDPASNs-aSAi------------LFRVASGsmda 593 Rhodoferax ferr...
Q5V5W9       540 ---------------------tvE-DWGTV---------------RATGSDessALl------------SVYPLGV---- 566 Haloarcula mari...
Q81K28       479 ------------------rivelFrNNHKVmemevttvtgvsiraLNEQTKpqvSGw------------VFPKMGEkrg- 527 Bacillus anthracis
Q02D12       538 ---------------------kvEtEGLRA---------------VTLNEGeanLTv------------AARADDG---- 565 Candidatus Soli...
EAY04736     308 ---------------------tvIsTNQ-----------------VRIGNGqksLLl------------TVESPSD---- 333 Trichomonas vag...
Q5LIC3       566 ----------------------tE-IPGKI---------------QLEVKG---KKa------------VIEYDKQlfd- 591 Bacteroides fra...
Q2YCG2       670 ------------------ievkqKaARACIn--------------MLQPHAiefAQn-----------nRFDAPPQipps 706 Nitrosospira mu...
4NEI_A       571 ---------------------mlGkRNGYQh-------------lWLRNTApvgDAseratwilddrfySYAFVTStps- 615 Saccharophagus ...
WP_015481708 586 tvpkslttlgdkygynhiwnegsG--TANAesi----------qfTWLDNR---RFy------------TLTSATSkn-- 636 Polaribacter sp...
3AFL_A       697 ---aveGFPDIDPKEFegLDIHHhvc--atVPAATRHrl---------vtLLVPYSLk---------------------- 740 Agrobacterium f...
Q220X2       594 aqkisiETGATADHWAvlVEGAGe------LKRVSRQd-----------tTITMGHVanstnpadsllvplrpapdvave 656 Rhodoferax ferr...
Q5V5W9       567 ------SDVRTTTTEY--FPEFGv------TEERQTL-------------ELEAGPE----------------------- 596 Haloarcula mari...
Q81K28       528 ---attIEVDISGSNVecITEFRl------KDFKLGRddli------pynLEKTFKStrnlryhfeeaknqkhkdklfvv 592 Bacillus anthracis
Q02D12       566 ------VTLRVVEGQEdpVQGWLprglsavRPAPVGIlsargvqanllyvLAPSPRGggdpvka-----------veaip 628 Candidatus Soli...
EAY04736     334 ------ATLSVTNNDP--IHDYDa------ENPNTKR-------------ILIKVNYa---------------------- 364 Trichomonas vag...
Q5LIC3       592 ---vktEIIPLTDTRL--SNVWGk------SICR----------------ITLTATNi---------------------- 622 Bacteroides fra...
Q2YCG2       707 rnendqGGARTTNDQW--HGRFQ-------TKERMAA-------------VEFLAVVd---------------------- 742 Nitrosospira mu...
4NEI_A       616 ---kkqNVLIAELGAN--DPNYNl------RQQQVLIrrveka-kqasfvSVLEPHGkydgslettsga-ysnvksvkhv 682 Saccharophagus ...
WP_015481708 637 -----deIIFARVGAN--DPKFNl------RKDPSIIirknnk-qnttfaSIIESHGtynpvkevaanayssfsnievis 702 Polaribacter sp...
3AFL_A       741 --EPKRIFSFI 749 Agrobacterium fabrum str. C58
Q220X2       657 raALTRAYANA 667 Rhodoferax ferrireducens T118
Q5V5W9       597 --SGTTAFGYL 605 Haloarcula marismortui
Q81K28       593 fsAMAPEYKFA 603 Bacillus anthracis
Q02D12       629 gdARAARISFR 639 Candidatus Solibacter usitatus Ellin6076
EAY04736     365 -aNEEKQIKVT 374 Trichomonas vaginalis G3
Q5LIC3       623 --YKTGNYSFT 631 Bacteroides fragilis NCTC 9343
Q2YCG2       743 --IDCKNIPIE 751 Nitrosospira multiformis ATCC 25196
4NEI_A       683 seNGKDVVVVD 693 Saccharophagus degradans 2-40
WP_015481708 703 syEDYTAIKVV 713 Polaribacter sp. MED152
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