1HM3,1N7Q,2WCO


Conserved Protein Domain Family
Lyase_8

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pfam02278: Lyase_8 (this model, PSSM-Id:396729 is obsolete and has been replaced by 460521)
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Polysaccharide lyase family 8, super-sandwich domain
This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Statistics
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PSSM-Id: 396729
Aligned: 86 rows
Threshold Bit Score: 197.864
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HM3_A              340 HHQFWNGDYVQHLRP--A--YSFNVRMVSKRTRRSEs-GNKENLLGRYLSDGATNIQLRgPEYY-NIMPVWEWDKIPGIT 413  Pedobac...
ESK88903            390 nrFFYVNDYMVHRGE--N--YLSTVKMFSTRTQNTEc-TNSQNPLGFHLADGVHYNYIVgDEYE-DIAASWNWNLIPGIT 463  Monilio...
XP_001873208        432 nNMFYDNDYMVHRGR--N--YVSTLKMYSSRTQNTEc-TNLQNPFGFHLSDGVLYTYLRgNEYE-DISAAWDWNLIPGIT 505  Laccari...
EKM83850            397 nRMFYNNDYMVHRGP--N--YVTTVKMYSTRTKYGEc-LNSQNILGFHLSDGAVYTYLKgNEYE-DIAVAWDWNLIPGIT 470  Agaricu...
WGS:AACS:CC1G_06734 351 TRMFFANDYMVHRGP--N--FFSSLKMYSSRTLNTEc-INSQNPLGFHLSDGTLYTYLRgNEYT-DISAAWDWDLIPGTT 424  Coprino...
jgi:Phep_2840       572 TDAFWVNEFLVHRRGenEkpFYVSLKLKSKRTVGAE--DFGNIRRSWYAGYGILPLKISgDEYSdKVLANLDWHALPGLT 649  Pedobac...
CDB11486            430 vrWFYNNDDLMKKTP--D--YHICINMASRRTDGLEsaAFADN-YNFYPTDGATLFQRDgDEYF-RVMGGWDVTAMPGVT 503  Bactero...
CDA75452            425 vRWFFNNDDLMKKTP--D--YHININMASYRTDGLEsaAFADN-YNFYPTDGATLFQRSgDEYF-HIMGGWDITAMPGVT 498  Bactero...
XP_001747490        390 HRHFYDSDYTIMRGD--G--FQYSIRMYSARTVNARc-VNDEGKQSQFTANGMVALYYTgYDYD-SIFPTWNWQQLPGTL 463  Monosig...
EDQ84702            308 HRHFFNSDYAIMRGE--N--FQYSIHMFSARTANAMc-VNTESKRSQFTASGMVARYYTgDEYE-SVFPTWNWQQLPGTL 381  Monosig...
1HM3_A              414 SRDYLTDrpltkl-wgeqgSNDFAGGVS-DgVYGASAYALDYDS-------------------------LQAKKAWFFFD 466  Pedobac...
ESK88903            464 VDYGATAlscdr--tgftgIEKFVGGVS-DgKIGLAAMRYTNPFtr----------------------sLRFQKVWFFLD 518  Monilio...
XP_001873208        506 VDYGATPlncdg--taasgVEAFVGGVS-TgQVGVAAMRYTNPNtt----------------------aLHWQKAWFFLQ 560  Laccari...
EKM83850            471 TDYEATKltcss---gvtgIEDFVGGVS-NdDTGIAVMRYTNPLtg----------------------dLNWQKAWFFLE 524  Agaricu...
WGS:AACS:CC1G_06734 425 VDYRNTLlhcsg--atvtgRESFVGGLS-DgKTGIAAMRYTNPTtr----------------------sLRWQKTWFFLN 479  Coprino...
jgi:Phep_2840       650 EEWRSDAipvgha-qaslpGDNEVAGVTsDgRSGVAIYHHLPREty---------------------ssATALKSYFFIA 707  Pedobac...
CDB11486            504 AREGMDKlvpvtnwrgycsKYNFAAGATdSgENGVAGYIFEKMHgadkenvndkg---drnvensllygFKAYKGYFILG 580  Bactero...
CDA75452            499 AREGMEKlqpvtnwrgycsKHNFAAGATdGsENGVAGIVFEKMNgsdkkavndkgdadkngiknellygFKAYKGYFILG 578  Bactero...
XP_001747490        464 LDQLPTApscgt--ttwqtNTEEVGGVS-NgKLGAAFMAQHQFr------------------------pMSCVRSWGMFP 516  Monosig...
EDQ84702            382 LDQQDEApncst--tlmsaHTSEVGGVS-NgVLGAAFMTQRARr------------------------pLKCVRSWAMYP 434  Monosig...
1HM3_A              467 KEIVCLGAGINSNAPEn---ITTTLNQSWLNGpvist------agktgRGKITTFKAQGQFWl-LHDAIGYY-FPEGa-- 533  Pedobac...
ESK88903            519 GDVQHVIISNIGSNTTs--pVYSVLDQRRHSGsvyvns----eqlqlqENQVTNVTNVTSLW---HGGVGYT-F--Nasa 586  Monilio...
XP_001873208        561 DDVQHVMVSGVASSSGa--pVYSVLDQRLHNGsimv---------dgsAQRQSNSTTALSLW---HGDVGYS-Fpk---- 621  Laccari...
EKM83850            525 GDVQHTMISNITSTSDs--pVFSVLDQRLHDDaifmdd-----gepfrANDGPTPLSSATLW---HGGVGYD-L-SGlgd 592  Agaricu...
WGS:AACS:CC1G_06734 480 DGAQHVVINILASSSGa--pVYSVLDQKRRNGltvv--------drreVLNSSTITGPQRLW---HDNVGYA-FRSLtna 545  Coprino...
jgi:Phep_2840       708 DKIIALGNNIKRLRPGqqkeIVTTLDQSAFTQpltiaqngktevvqpgQSVNLSFEADKPVWl-HIGNKGYIiYP----- 781  Pedobac...
CDB11486            581 DYFVALGAGVTNMNPDeeghIRTTLDQTALTGevfitrng-kkevlgkGETTLEGNKKKAIWltQQGKFSYCiLPEYt-- 657  Bactero...
CDA75452            579 DYFVALGAGVTNMTPNiegdIRTTIDQTSLVNntyilnkgkkhvlslgDEVELKSNKSNPVWlvQEGKFAYTlLPKYt-- 656  Bactero...
XP_001747490        517 DALIATAHSITAPDDIa--sVFTLADRRAASTvtialhn--gthltlaADQLISLPAAEVAWv-HHDNTLYA-LSNEl-- 588  Monosig...
EDQ84702            435 DALFATAHRISVPDKVp--vVFTLEDARARSTvtvalkn--gdqleiaSHRPIRLAADTVAWi-HHDKTLYA-LSSKf-- 506  Monosig...
1HM3_A              534 --NLSLSTQ----SQKGNWFHINnsHSKDE----VSGDVFKLWINHGARPe-NAQYAYIVLPGIN 587  Pedobacter heparinus
ESK88903            587 pfSLSLDVG----PKTGNWATIGt-SKQPP----ATVDLFAAWLQHTSLSs---PLAYSVYPGTD 639  Moniliophthora roreri ...
XP_001873208        622 paSLSVQFG----NKTGNWSSIGt-STQPA----SAVDLFAAWIQHTSLNt---SIEYTTFPGTT 674  Laccaria bicolor S238N...
EKM83850            593 ddILHVEVG----PKSGNWSAIGt-STEPP----STFDLFAAWIEHGTPAs---SISYSTFPGTS 645  Agaricus bisporus var....
WGS:AACS:CC1G_06734 546 ttPLHVRMG----ERTGSWSAIGt-STQPP----VSVDMWAGLLEHIDLSq---PLEYTILPGTS 598  Coprinopsis cinerea ok...
jgi:Phep_2840       782 --DGKQKII----VKTGTEINIT--DPANA----SKTPGYIIAVNHGQEPatGNGYSYFLVPNVl 834  Pedobacter heparinus D...
CDB11486            658 -sKAFVACE----TRPTNWLKLNp-SNKKTanlpEQVQILRIWADHGQQPv-NDTYGYAVYTGqg 715  Bacteroides sp. CAG:633
CDA75452            657 -dKAKVSCE----MKPTDWKKMNp-SNKNTdkmsKEVKILRLWVNHGQTPv-NDVYGYAVYTGkg 714  Bacteroides sp. CAG:530
XP_001747490        589 -gPVHGTLAifcgNSTGNWIDIGv-TNRTE----TVDRFFAKWQ--LPTPt-PHSAGYLMVPAVS 644  Monosiga brevicollis MX1
EDQ84702            507 -gPVDGTLEifrgWANGSWLDIGt-DPRPE----TVDRFFLKWV--FPKPa-PSSAGYLMIPSVp 562  Monosiga brevicollis MX1
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