4V1X,2P53,2VHL,6RP1,4GOA,5UQC,3MTW,6OHB,6OHA


Conserved Protein Domain Family
Amidohydro_1
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pfam01979: Amidohydro_1 (this model, PSSM-Id:396526 is obsolete and has been replaced by 460401)
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Amidohydrolase family
This family of enzymes are a a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyzes adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyze the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.
Links
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Statistics
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PSSM-Id: 396526
Aligned: 57 rows
Threshold Bit Score: 104.114
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4V1X_A  77 VVLPGFI---NAHTHVNQILLRGGpshgrqfydwlfnvvypgqkaMRPEDVAVAVRLYCAEAVRSGITTINENADsaiyp 153 Pseudomonas sp. ADP
O34909  78 YIVPGYI---EPHAH-PFQIY------------------------NPQTLAEYVSQYGTTTFVNDNLFLLLQSGKk---- 125 Bacillus subtilis sub...
P39761  66 MIVPGFI---DGHVHIESSMV------------------------TPIEFAKAVLPHGVTTVVTDPHEIANVSGEk---- 114 Bacillus subtilis sub...
P31441  81 TAVPGFI---DAHLHIESSMM------------------------TPVTFETATLPRGLTTVICDPHEIVNVMGEa---- 129 Escherichia coli K-12
Q58854  58 YLSPTFI---DGHIHIESSHL------------------------IPSEFEKFVLKSGVSKVVIDPHEIANIAGKe---- 106 Methanocaldococcus ja...
O26952  39 IIIPGFI---DAHLHIESSML------------------------IPSSFAAAAIPHGTVSAISDPHEIANVMGVd---- 87  Methanothermobacter t...
O50821  43 YVLPGFI---DAHIHIESSFL------------------------VPSNFAHLVVAHGTVATISDPHEIANVNGId---- 91  Borreliella burgdorfe...
P57416   5 VKKIKIIkpdDWHVHLRDNEILNQ---------------------VIKYTGKFYKRAVIMPNLNSPITSCLKSIA----- 58  Buchnera aphidicola s...
5UQC_B  50 MVIPGGI---DVHTRFQMP--------------------------DQGMTSADDFFQGTKAALAGGTTMIIDHVVp---- 96  house mouse
P46538  51 LIVPGLI---DLHVHLR----------------------------EPGGEAKETIETGTLAAAKGGFTTVAAMPNt---- 95  [Bacillus] caldolyticus

4V1X_A 154 gNIEAAMAVYGEV--GVRVVYARMFFDrmDgriqgyvdalkarspqvelcsimEETAvaKDRITALSDQY----HGTAGG 227 Pseudomonas sp. ADP
O34909 126 -KALTILNELKKQpvQYFWW---------Sr----------------------YDLQteVLNEDHVLPFDvrkqWIEHPD 173 Bacillus subtilis sub...
P39761 115 -GIEFMLEQARHTplNIHFMLPSSVPA--As----------------------FERSgaILKAADLk------pFYEEEE 163 Bacillus subtilis sub...
P31441 130 -GFAWFARCAEQArqNQYLQVSSCVPAleG-----------------------CDVNgaSFTLEQMl------aWRDHPQ 179 Escherichia coli K-12
Q58854 107 -GILFMLNDAKIl--DVYVMLPSCVPAt------------------------nLETSgaEITAENIe------eLILLDN 153 Methanocaldococcus ja...
O26952  88 -GVRFMIDDAAATpmKFYFTAPSCVPAt------------------------pFETAgaEITARGIe------eLLRMDS 136 Methanothermobacter t...
O50821  92 -GINFMINNSKKTefKFFFGAPSCVPAlsQe----------------------FETSgyVLNDKDId------eLMKLDD 142 Borreliella burgdorfe...
P57416  59 -YRNRILKSMHLn----------------------------------------YKFKplMTCYLTNSTSPkeleFGFSKK 97  Buchnera aphidicola s...
5UQC_B  97 ePGTSLLAAFDQwrewad-----------------------------sksccdYSLHvdITEWHKGIQEEmealVKDHGV 147 house mouse
P46538  96 nPAPDRKEQMEW-----------------------------------------LQARirETARVNVLPYAaitiGQKGEE 134 [Bacillus] caldolyticus

4V1X_A 228 RIS-VWPAPATTTAVTVE--------GMRWAQA-----FARDR-AVMWTLHM--AESDHD----ERIHG---MS--PAEY 281 Pseudomonas sp. ADP
O34909 174 VIQgGEMTGWPRLVDGDD--------LMLHCMQ-----ATKKQ-RKRIEGHFpgASDKTLtkmkLFGADcdhEAmtGDEV 239 Bacillus subtilis sub...
P39761 164 VLGlAEVMDYVSVQQAEK--------DMVQKLL-----DARVA-GKRIDGHLagLSTDLIniyrTAFVLndhEVtsKEEA 229 Bacillus subtilis sub...
P31441 180 VTGlAEMMDYPGVISGQN--------ALLDKL------DAFR--HLTLDGHCpgLGGKELnayiTAGIEnchESyqLEEG 243 Escherichia coli K-12
Q58854 154 VLGlGEVMNYPAVINEDE--------EMLKKIE-----VAKKY-NKLIDGHCpkLKGWELnkyiSHGIMsdhESvdEDEA 219 Methanocaldococcus ja...
O26952 137 VVAlGEMMNFPAVIAGDD--------GVMAKIK-----AARDL-NMPVDGHAplLSGDELctyiGAGIStdhECvsPEEV 202 Methanothermobacter t...
O50821 143 IYYlAEVMDFKGVINKDI--------EIINKIN-----SALKR-NKVVDGHApgLSPNLTlkyaSSGIStdhECltIEDA 208 Borreliella burgdorfe...
P57416  98 IFVaAKFYPNGCTTNSKT--------GIKKISDitpvlECMEKiGMPLLIHGeeINQNIDiydrEAKFIektLDplRKKF 169 Buchnera aphidicola s...
5UQC_B 148 NSFlVYMAFKDRFQLTDS--------QIYEVLS-----VIRDI-GAIAQVHAenGDIIAEeqqrILDLGitgPEghVLSR 213 house mouse
P46538 135 LTDfAALKEAGAFAFTDDgvgvqsagMMFEAMK-----QAAAL-DMAIVAHCedDTLTNGgavhDGEFArryGLrgIPSV 208 [Bacillus] caldolyticus

4V1X_A 282 MEC---YGLLDE-RLQVAHCVYFD---RK--------DVRLLHRH--NVKVA---------SQVVSNAY----------- 324 Pseudomonas sp. ADP
O34909 240 MRR-------------LELGYYVSlrnSS--------------------------------------------------- 255 Bacillus subtilis sub...
P39761 230 LDR-------------IRRGMYVMmreGS--------------------------------------------------- 245 Bacillus subtilis sub...
P31441 244 RRK-------------LQLGMSLMireGS--------------------------------------------------- 259 Escherichia coli K-12
Q58854 220 LEK-------------LRLGLKLMireGT--------------------------------------------------- 235 Methanocaldococcus ja...
O26952 203 LEK-------------RRLGMKIMareGS--------------------------------------------------- 218 Methanothermobacter t...
O50821 209 RYK-------------LSLGMKILireGS--------------------------------------------------- 224 Borreliella burgdorfe...
P57416 170 PKL----------KIVLEHITTKEsveYIknndvnylSATITPHHlmLNRNDmfyggiqpyLYCLPILK----------- 228 Buchnera aphidicola s...
5UQC_B 214 PEEveaEAVNRSiTIANQTNCPLYvtkVMs------kSAAEVIAQarKKGTVvygepitasLGTDGSHYwsknwakaaaf 287 house mouse
P46538 209 CEA---VHIARDvLLAEAAGCHYHvchISt------kESVRVVRDakRAGIRvtaevtphhLLLCDEDIpgldany---- 275 [Bacillus] caldolyticus

4V1X_A 325 -------LGSGVAPVPEMVER-GMA----VGIGTDnG--------NSNDSVNMIGDMKFMAHIHRav---hrDADV-LTP 380 Pseudomonas sp. ADP
O34909 256 -------IRPDVRKILQELHEkGFRyydhFFYTTDgAtpnf-ykgGMTNEL-----IRIAL-------------EEgVPA 309 Bacillus subtilis sub...
P39761 246 -------VAKNTLNVLPAVNEkNARr---FFFCTDdKhvddllseGSVNHQ-----VKMAI-------------QAgLNP 297 Bacillus subtilis sub...
P31441 260 -------AARNLNALAPLINEfNSPq---CMLCTDdRnpweiaheGHIDAL-----IRRLI-------------EQhNVP 311 Escherichia coli K-12
Q58854 236 -------ASKNIYLLNICKKIkDFRn---IMLVSDdVcik--dldGYMLNI-----LRKAT--------------NyVSP 284 Methanocaldococcus ja...
O26952 219 -------SARNLRDLAAAGCDf---------LVSDdIhpad-lleGHMDRI-----LRRAV-------------DYgIDP 263 Methanothermobacter t...
O50821 225 -------AAKNFESLHPLISEcSKKycdsLMFCFDdAhpnd-ilnGHINLI-----VARAI-------------KHgHDF 278 Borreliella burgdorfe...
P57416 229 -------KNKHRMALRKAISNgDKH----FFLGSDtAphlhknkiNMLGCA-----GIFNAPSSLlsyvkvfEEMRaLKY 292 Buchnera aphidicola s...
5UQC_B 288 vtspplsPDPTTPDFLNSLLScGDL----QVTGSAhCtfntaqkaVGKDNFTLIPEGTNGTEERMsviwdkaVVTGkMDE 363 house mouse
P46538 276 kmnpplrSREDRDALIEGLLD-GTI----DFIATDhAphtaaekaKGIEAAPF---GIVGLETAFpllythfVKTGvFTL 347 [Bacillus] caldolyticus

4V1X_A 381 EK-ILEMATIDGARSLGMdhEIGSIETGKRADLILLDlr-hpQTtph----hhlAATIVFQAYGNevdTVLIDGNVV 451 Pseudomonas sp. ADP
O34909 310 ID-AYNMASFNIAKYYQMddYLGVVGPGRLASLNIL-----------------------EDPLNPnpvTVLSKGTIL 362 Bacillus subtilis subsp....
P39761 298 FL-AYQLGSLNAAECYGLd-TKGAIAPGFDADLLFV-----------------------SDLENVtvtMTMVKGQTV 349 Bacillus subtilis subsp....
P31441 312 LHvAYRVASWSTARHFGLn-HLGLLAPGKQADIVLL-----------------------SDARKVtvqQVLVKGEPI 364 Escherichia coli K-12
Q58854 285 IE-AIQMVTINPANYFGF--DVG-IKAGNEASFVIF-----------------------EDLDNFkvyNIVIKGRFL 334 Methanocaldococcus janna...
O26952 264 VS-AVQMVTINPAEHYGL--STGAIAPGWDADFVVV-----------------------DSLRDFnvkRVYIDGRPV 314 Methanothermobacter ther...
O50821 279 FD-VLKIACINPVLHYKI--PVGLLRIGDPADFIIT-----------------------KDIKTFkinKTYINGKLV 329 Borreliella burgdorferi B31
P57416 293 LQ---SFCSENGPKFYNMpiNKETITIIKKPCKIIK-----------------------KINVGRnviIPFLSGEIL 343 Buchnera aphidicola str....
5UQC_B 364 NQ-FVAVTSTNAAKVFNLypRKGRISVGSDADLVIWDpdsvkTIsakthnsaleYNIFEGMECRGsplVVISQGKIV 439 house mouse
P46538 348 KQ-LVDWLTIKPAQCFGL--KAGRLAVGAPADIAVIDleteeAIdpetfaskgkNTPFAGWVCQGwpvMTFVGGTLV 421 [Bacillus] caldolyticus
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