3QHP,2IV7,5D00,5N7Z


Conserved Protein Domain Family
Glycos_transf_1
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pfam00534: Glycos_transf_1 (this model, PSSM-Id:395425 is obsolete and has been replaced by 425737)
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Glycosyl transferases group 1
Mutations in this domain of PIGA lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
Links
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Statistics
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PSSM-Id: 395425
Aligned: 45 rows
Threshold Bit Score: 79.614
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3QHP_A   1 TPFKIAMVGRYSNE-KNQSVLIKAVALSKy------kQDIVLLLKGkgpd----------ekkiKLLAQKLGVKAEFGFV 63  Helicobacter pylori 2...
P43636 216 GDRFYLSINRFEKK-KDVALAIKAFALSEdq----inDNVKLVICGgydervae--nveylkelQSLADEYELSHTTIYY 288 Saccharomyces cerevis...
P44806 246 EDEIILKSHRALLA-KYPNLLLLLVPr---------hPERFNVVADllkke---------kfqfIRRSTNELPNENTQVI 306 Haemophilus influenza...
P54166 195 KYNLSPNKKVLLIM-AGAHGVLKNVKELCenlv-kddQVQVVVVCGknta-----------lkeSLSALEAENGDKLKVL 261 Bacillus subtilis sub...
Q43009 574 KKPIIFSMARLDHV-KNLTGLVELYGRNPrl----qeLVNLVVVCGdhgkeskdkeeqaefkkmFNLIEQYNLNGHIRWI 648 Japanese rice
P37751 196 PSELTIFYPAVPRVfKNYELIISAARKLKeq----snIKFLLTISGten------------ayaKYIISLAEGLDNVHFL 259 Escherichia coli K-12
P72900 190 TQPYFLYVGARGTY-KNFDQLLLAFQKVTakp---kyADLLLCVVGspfe-----------nqeKERLEFLGLSKNVVHY 254 Synechocystis sp. PCC...
O67183 411 KEPFFLMVSTLEPR-KGHFQVLKAFEILWkk-----gINVNLVIVGkegwk--------vrklvKHIKKHRFLGKHLFWF 476 Aquifex aeolicus
P53954 305 RLNQAIVLAQFRPE-KRHKLIIESFATFLknlp-dsvSPIKLIMAGstrskqd----enyvkslQDWSENVLKIPKHLIS 378 Saccharomyces cerevis...
Q19265 208 TKYVFTSLNRFERK-KNIVLALDAFEKLKsnlpadefSQCHLVIAGgydlknpe--niehydelVEHMKKLELPADQIVF 284 Caenorhabditis elegans

3QHP_A  64 NSNE----LLEILKT----CTLYVHAANV--------------------ESEAIACLEAISVGIVPVIANsPLSATRQFA 115 Helicobacter pylori 2...
P43636 289 QEIKrvsdLESFKTNn---SKIIFLTSISsslkelllertemllytpayEHFGIVPLEAMKLGKPVLAVN-NGGPLETIK 364 Saccharomyces cerevis...
P44806 307 LGDSmg-eLMLMYGI----SDIAFVGGSLv-------------------KHGGHNPLEPLAFKMPVITGKhTFNFPEIFR 362 Haemophilus influenza...
P54166 262 GYVEr---IDELFRI----TDCMITK------------------------PGGITLTEATAIGVPVILYKpVPGQEKENA 310 Bacillus subtilis sub...
Q43009 649 SAQMnrvrNGELYRYicdmRGAFVQPALY--------------------EAFGLTVIEAMTCGLPTFATA-YGGPAEIIV 707 Japanese rice
P37751 260 GYLDke-kIDHCYNI----SDIVCFPSRL--------------------ETWGLPLSEAKERGKWVLASD-FPFTRETLG 313 Escherichia coli K-12
P72900 255 GRATdg-qLAKLYNQ----SIAFVYPSLY--------------------EGFGIPPLEAMACGTAVIGSN-VSSIPEVVG 308 Synechocystis sp. PCC...
O67183 477 GYVSde-lLKELYKR----ALALIAASED--------------------EGFGLPIVEAFRNNTPVIARD-IKVFREIAG 530 Aquifex aeolicus
P53954 379 FEKNlpfdKIEILLN----KSTFGVNAMWn-------------------EHFGIAVVEYMASGLIPIVHAsAGPLLDIVT 435 Saccharomyces cerevis...
Q19265 285 LHSPsdtqKVNLIRR----SRAVLYTPDR--------------------EHFGIVPVEAMYLGTPVIAVN-TGGPCESVR 339 Caenorhabditis elegans

3QHP_A 116 LDEr---------SLFEPN--NAKDLSAKIDWWLENKle------rERMQNEYAKSA 155 Helicobacter pylori 26695
P43636 365 SYVagenessatgWLKPAVpiQWATAIDESRKILQNG---------SVNFERNGPLR 412 Saccharomyces cerevisiae S288C
P44806 363 MLVev------qgVLEVNS--TADALERAVEALLNSKe-------sRERLGNAGYEV 404 Haemophilus influenzae Rd KW20
P54166 311 NFFed------rgAAIVVN--RHEEILESVTSLLADEd-------tLHRMKKNIKDL 352 Bacillus subtilis subsp. subtilis str. 168
Q43009 708 HGVs--------gYHIDPYq-NDKASALLVEFFEKCQe-------dPNHWIKISQGG 748 Japanese rice
P37751 314 SYEk--------kAFFDSN--NDDMLVKLIIDFKKGNlkk---disDANFIYRNENV 357 Escherichia coli K-12
P72900 309 DAG----------LLFDPK--SMDQLVDQLLYVLENPi-------kRDSLIQKGKKQ 346 Synechocystis sp. PCC 6803
O67183 531 DNA----------FFFENTk-NPEVIANAIKTWLELYrkgl--hpkPANLKQYKYTW 574 Aquifex aeolicus
P53954 436 PWDan-------gNIGKAPp-QWELQKKYFAKLEDDGettgfffkePSDPDYNTTKD 484 Saccharomyces cerevisiae S288C
Q19265 340 NNEt--------gFLVDQT---AEAFAEKMIDLMKDEe-------mYRRMSEEGPKW 378 Caenorhabditis elegans
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