2ASI,2APR,5RD2,1J71,3Q70,7AGB,1HTR,5MLG,5SY2,4CMS


Conserved Protein Domain Family
Asp

?
pfam00026: Asp (This model is not part of the current CDD release)
Click on image for an interactive view with Cn3D
Eukaryotic aspartyl protease
Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.
Statistics
?
PSSM-Id: 394983
Aligned: 24 rows
Threshold Bit Score: 267.988
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
?
Program:
Drawing:
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2ASI_A  19 EYAIPVSIGTPGQDFLLLFDTGSSDTWVPHKG----------------------CTk-SEG-----CVGSRF-FDPSASS 69  Rhizomucor miehei
2APR_A  16 EYYGQVTIGTPGKKFNLDFDTGSSDLWIASTL----------------------CTn---------CGSGQTkYDPNQSS 64  Rhizopus microsporus ...
5RD2_A 105 AYITPVQIGTPAQTLNLDFDTGSSDLWVFSSE----------------------TT--ASE-----VDGQTI-YTPSKST 154 chestnut blight fungus
P17946  84 EYLTPVTVGKS--TLHLDFDTGSADLWVFSDE----------------------LP--SSE-----QTGHDL-YTPSSSA 131 Aspergillus awamori
P32834  75 GYFANLTLGSNERVYSLTLDTGSPYTWVTAKNitalsaseiwsdtdgvdagrstSDirTNA-----CTNYTC-FDYSSTT 148 Schizosaccharomyces p...
P22929  74 FYLTTIEIGTPGQKLQVDVDTGSSDLWVPGQG----------------------T-----------SSLYGT-YDHTKST 119 Saccharomycopsis fibu...
P12630  44 YYATTLDIGTPSQSLTVLFDTGSADFWVMDSSnpfclpnsntssysnatyngeeVKp-SID-----CRSMST-YNEHRSS 116 Saccharomyces cerevis...
1J71_A  13 SYAADIVVGSNQQKQTVVIDTGSSDLWVVDTDa--------------------eCQvtYSGqtnnfCKQEGT-FDPSSSS 71  Candida tropicalis
3Q70_A  13 TYAADITVGSNNQKLNVIVDTGSSDLWVPDVNv--------------------dCQvtYSDqtadfCKQKGT-YDPSGSS 71  Candida albicans
7AGB_D  13 SYASKVSVGSNKQQQTVIIDTGSSDFWVVDSNa--------------------qCGk-GVD-----CKSSGT-FTPSSSS 65  Candida parapsilosis
2ASI_A  70 TFK-ATNYNL-NIT-YGTG-GANGLYFEDSIAIGDITVTKQILAYVDNVRGPTAEQSPnadifLDGLFGAA----YPDNT 141 Rhizomucor miehei
2APR_A  65 TYQ-ADGRTW-SIS-YGDGsSASGILAKDNVNLGGLLIKGQTIELAKREAAS-FASGP-----NDGLLGLG----FDTIT 131 Rhizopus microsporus ...
5RD2_A 155 TAKlLSGATW-SIS-YGDGsSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDST-----IDGLLGLA----FSTLN 223 chestnut blight fungus
P17946 132 TK--LSGYTW-DIS-YGDGsSASGDVYRDTVTVGGVTTNKQAVEAASKISSEFVQNTA-----NDGLLGLA----FSSIN 198 Aspergillus awamori
P32834 149 ARR-TNSSTIgFLAsYGDNtTVLGYNMVDNAYFAGLTLPGFEFGLATREYDSSQISV------TPGIIGLSvamtITGIS 221 Schizosaccharomyces p...
P22929 120 SYK-KDRSGF-SIS-YGDGsSARGDWAQETVSIGGASITGLEFGDATSQDV------------GQGLLGIG----LKGNE 180 Saccharomycopsis fibu...
P12630 117 TYQyLENGRF-YIT-YADGtFADGSWGTETVSINGIDIPNIQFGVAKYATTP-----------VSGVLGIG----FPRRE 179 Saccharomyces cerevis...
1J71_A  72 SAQ-NLNQDF-SIE-YGDLtSSQGSFYKDTVGFGGISIKNQQFADVTTTSV------------DQGIMGIG----FTADE 132 Candida tropicalis
3Q70_A  72 ASQ-DLNTPF-KIG-YGDGsSSQGTLYKDTVGFGGVSIKNQVLADVDSTSI------------DQGILGVG----YKTNE 132 Candida albicans
7AGB_D  66 SYK-NLGAAF-TIR-YGDGsTSQGTWGKDTVTINGVSITGQQIADVTQTSV------------DQGILGIG----YTSNE 126 Candida parapsilosis
2ASI_A 142 AME------AEYGstYNTvhvnLYKQGLISSPLFSVYMN--TNSGTGEVVFGGVNNTLLGGDIAYTDVMSr------yGG 207 Rhizomucor miehei
2APR_A 132 TVRg-----VKTP--MDN----LISQGLISRPIFGVYLGkaKNGGGGEYIFGGYDSTKFKGSLTTVPIDNs-------RG 193 Rhizopus microsporus ...
5RD2_A 224 TVSpt---qQKTF--FDN------AKASLDSPVFTADL---GYHAPGTYNFGFIDTTAYTGSITYTAVSTk-------QG 282 chestnut blight fungus
P17946 199 TVQpk---aQTTF--FDT----VKSQ--LDSPLFAVQL---KHDAPGVYDFGYIDDSKYTGSITYTDADSs-------QG 257 Aspergillus awamori
P32834 222 SDDkv--vaFTPPtiVDQ----LVSANVIDTPAFGIYLN----EDVGELIFGGYDKAKINGSVHWVNISSsd-----dST 286 Schizosaccharomyces p...
P22929 181 ASAqs---sNSFT--YDNlplkLKDQGLIDKAAYSLYLNs-EDATSGSILFGGSDSSKYSGSLATLDLVNiddegdstSG 254 Saccharomycopsis fibu...
P12630 180 SVKgy---eGAPNeyYPNfpqiLKSEKIIDVVAYSLFLNs-PDSGTGSIVFGAIDESKFSGDLFTFPMVNeyptivdaPA 255 Saccharomyces cerevis...
1J71_A 133 A--------GYNL--YDNvpvtLKKQGIINKNAYSLYLNs-EDASTGKIIFGGVDNAKYTGTLTALPVTS--------SV 193 Candida tropicalis
3Q70_A 133 AGG------S-----YDNvpvtLKKQGVIAKNAYSLYLNs-PDAATGQIIFGGVDNAKYSGSLIALPVTS--------DR 192 Candida albicans
7AGB_D 127 AVYdtsgrqTTPN--YDNvpvtLKKQGKIRTNAYSLYLNs-PSAETGTIIFGGVDNAKYSGKLVAEQVTS--------SQ 195 Candida parapsilosis
2ASI_A 208 YyfWDAPVTGITVDGSAA-----VRFSRPQAFt------IDTGTNFFIMPSSAASKIVKAALPDATETqqg---wvVPCA 273 Rhizomucor miehei
2APR_A 194 W--WGITVDRATVGTSTV-------ASSFDGI-------LDTGTTLLILPNNIAASVARAYGASDNGDgt----ytISCD 253 Rhizopus microsporus ...
5RD2_A 283 F--WEWTSTGYAVGSGTF------KSTSIDGI-------ADTGTTLLYLPATVVSAYWAQVSGAKSSSsvg--gyvFPCS 345 chestnut blight fungus
P17946 258 Y--WGFSTDGYSIGDGSS------SSSGFSAI-------ADTGTTLILLDDEIVSAYYEQVSGASGETeag--gyvFSCS 320 Aspergillus awamori
P32834 287 F--YSVNLESITVTNSTSsnnvqSSKRSSKDIevnttvtLDTGTVYIYLPEDTVESIADQYQGIVSEYgy----vvIYCD 360 Schizosaccharomyces p...
P22929 255 AvaFFVELEGIEAGSSSI------TKTTYPAL-------LDSGTTLIYAPSSIASSIGREYGTYSYSYgg----yvTSCD 317 Saccharomycopsis fibu...
P12630 256 T--LAMTIQGLGAQNKSScehetFTTTKYPVL-------LDSGTSLLNAPKVIADKMASFVNASYSEEegi---yiLDCP 323 Saccharomyces cerevis...
1J71_A 194 E--LRVHLGSINFDGTSV-------STNADVV-------LDSGTTITYFSQSTADKFARIVGA--TWDsrneiyrlPSCD 255 Candida tropicalis
3Q70_A 193 E--LRISLGSVEVSGKTI------NTDNVDVL-------LDSGTTITYLQQDLADQIIKAFNGKLTQDsngnsfyeVDCN 257 Candida albicans
7AGB_D 196 A--LTISLASVNLKGSSF-------SFGDGAL-------LDSGTTLTYFPSDFAAQLADKAGARLVQVardqylyfIDCN 259 Candida parapsilosis
2ASI_A 274 SyQNSKSTISIVMqksgsssDTIEISVPVSKML--LPVDqs--neTCMFII-LPDGGNQYIVGNLFLRFFVNVYD-FGNN 347 Rhizomucor miehei
2APR_A 254 T--SAFKPLVFSI-------NGASFQVSPDSLV--FEEFq----gQCIAGF-GYGNWGFAIIGDTFLKNNYVVFN-QGVP 316 Rhizopus microsporus ...
5RD2_A 346 A---TLPSFTFGV-------GSARIVIPGDYID--FGPIstg-ssSCFGGIqSSAGIGINIFGDVALKAAFVVFNgATTP 412 chestnut blight fungus
P17946 321 T---NPPDFTVVI-------GDYKAVVPGKYIN--YAPIstg-ssTCFGGIqSNSGLGLSILGDVFLKSQYVVFN-SEGP 386 Aspergillus awamori
P32834 361 S-FSDSDYISFNFg------SDADFHVSVNDLV--IYRQestsgdICYLAL-FEGDTSSYLLGQYFLQYVYSIYD-WDAQ 429 Schizosaccharomyces p...
P22929 318 A---TGPDFKFSF-------NGKTITVPFSNLL--FQNSeg--dsECLVGV-LSSGSNYYILGDAFLRSAYVYYD-IDNS 381 Saccharomycopsis fibu...
P12630 324 V-SVGDVEYNFDF-------GDLQISVPLSSLI--LSPEte--gsYCGFAV--QPTNDSMVLGDVFLSSAYVVFD-LDNY 388 Saccharomyces cerevis...
1J71_A 256 --LSGDAVFNFD--------QGVKITVPLSELI--LKDSds---sICYFGI---SRNDANILGDNFLRRAYIVYD-LDDK 316 Candida tropicalis
3Q70_A 258 --LSGDVVFNFS--------KNAKISVPASEFAasLQGDdgqpydKCQLLF---DVNDANILGDNFLRSAYIVYD-LDDN 323 Candida albicans
7AGB_D 260 TdTSGTTVFNFG--------NGAKITVPNTEYV--YQNGd----gTCLWGI---QPSDDTILGDNFLRHAyLLYN-LDAN 321 Candida parapsilosis
2ASI_A 348 RIGFAPL 354 Rhizomucor miehei
2APR_A 317 EVQIAPV 323 Rhizopus microsporus var. chinensis
5RD2_A 413 TLGFASK 419 chestnut blight fungus
P17946 387 KLGFAAQ 393 Aspergillus awamori
P32834 430 KIGLAAL 436 Schizosaccharomyces pombe 972h-
P22929 382 QVGIAQA 388 Saccharomycopsis fibuligera
P12630 389 KISLAQA 395 Saccharomyces cerevisiae S288C
1J71_A 317 TISLAQV 323 Candida tropicalis
3Q70_A 324 EISLAQV 330 Candida albicans
7AGB_D 322 TISIAQV 328 Candida parapsilosis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap