5AIL,3Q71,3V2B,3VFQ,4ABK,5O2D


Conserved Protein Domain Family
Macro_BAL-like

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cd02903: Macro_BAL-like 
macrodomain, B-aggressive lymphoma (BAL)-like family
Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Members of this family show similarity to BAL (B-aggressive lymphoma) proteins, which contain one to three macrodomains. Most BAL family macrodomains belong to this family except for the most N-terminal domain in multiple-domain containing proteins. This family includes the second and third macrodomains of mono-ADP-ribosyltransferase PARP14 (PARP-14, also known as ADP-ribosyltransferase diphtheria toxin-like 8, ATRD8, B aggressive lymphoma protein 2, or BAL2). Most BAL proteins also contain a C-terminal PARP active site and are also named as PARPs. Human BAL1 (or PARP-9) was originally identified as a risk-related gene in diffuse large B-cell lymphoma that promotes malignant B-cell migration. Some BAL family proteins exhibit PARP activity. Poly (ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins. BAL proteins may also function as transcriptional repressors.
Statistics
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PSSM-Id: 394874
Aligned: 24 rows
Threshold Bit Score: 179.757
Created: 20-Sep-2005
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
ADP-ribose
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ADP-ribose binding site [chemical binding site]
Evidence:
  • Structure:3Q71: human Poly [ADP-ribose] polymerase 14 binds adenosine-5-diphosphoribose, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         ###          ###        ####  #                                 
5AIL_A          3 NAMVVn-nLTLQIVQGHIEwq-tADVIVNSVNPh---DITVGPVAKSILQQAGVeMKSEFLATKAKQfq-rsQLVLVTKG 76   human
3Q71_A         31 GSLVSpggLQMLLVKEGVQna-kTDVVVNSVPLd--lVLSRGPLSKSLLEKAGP-ELQEELDTVGQGvavsmGTVLKTSS 106  human
3V2B_A         26 YEMKIg-aITFQVATGDIAte-qVDVIVNSTARt---FNRKSGVSRAILEGAGQ-AVESECAVLAAQp---hRDFIITPG 96   human
4ABK_A         15 YEMKIg-sIIFQVASGDITke-eADVIVNSTSNs---FNLKAGVSKAILECAGQ-NVERECSQQAQQr---kNDYIITGG 85   human
AAP91749       72 HDYKIg-eITVQVANCGITdltkSNIIVNSVGPd--fELSKGQVSAILLRRVGP-QLQTECTNNPKFa---tESYRITTG 144  Ciona intesti...
XP_002125042  289 VRMVPr--AEVNLFKGDITke-nVDAIVIGVAKqdltNLGNSPLAGAVLKAAGK-ELQDDCNASAASkp-dmWSVVQVNS 363  vase tunicate
NP_001107919 1204 HETTVg-gVTLQVLNGDITte-qTDVIVNSTTKe---FTLKAGVSKAILDKAGP-NVEAECQQLGAKt---dSGLIMTQA 1274 zebrafish
XP_007894519 1266 TQIKIh-eTIVEVKQGDITld-tVKAIVNSTNTt---LNLNSGVSGAIFTAAGN-TVVDECKKLGTQp---aDGVVVTGP 1336 elephant shark
XP_013090473  868 DSIKLfqdISVNVMQGEINkq-rTDVIVITVDKs--lDLTKGKISHTILKEAGD-EIQDELKLNYNDgl-kaNQFAKTSG 942  Biomphalaria ...
XP_013397857  707 HLMEGg--IKITLVQADITkdrwSSVLVNVVTEk---LTLQYGLAKIFLNAAGE-ELEKALSSQAPGn---fGEVKVTAR 777  Lingula anatina
Feature 1                                                              #######                    
5AIL_A         77 FNLf---CKYIYHVLWHSEfpk-----pqiLKHAMKECLEKCIEqnITSISFPALGTGNMEIKKETAAEILFDEVLTFAK 148  human
3Q71_A        107 WNLd---CRYVLHVVAPEWrngst-sslkiMEDIIRECMEITESlsLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSS 182  human
3V2B_A         97 GCLk---CKIIIHVPGGKD-----------VRKTVTSVLEECEQrkYTSVSLPAIGTGNAGKNPITVADNIIDAIVDFSS 162  human
4ABK_A         86 GFLr---CKNIIHVIGGND-----------VKSSVSSVLQECEKknYSSICLPAIGTGNAKQHPDKVAEAIIDAIEDFVQ 151  human
AAP91749      145 GNL----CDHIVHYVLPNKey--------rIEESIMELLEKCDNmeAITVVMPVLGSGNRGVPVDKCARFLWAAICLLNS 212  Ciona intesti...
XP_002125042  364 HQLp---CIRVYIVLMEHYnennsekikksYSAAVKKCLENAEGngFSTISFCAMGAGGMEYPIEEIARWMQDEFRAFRT 440  vase tunicate
NP_001107919 1275 GNLq---CKKIIHIAAQSNai--------mIQKHVRKALEMCAKekLTSIAFPAIGTGQAGLSPGQVADSMLDGMLEMLR 1343 zebrafish
XP_007894519 1337 GNLn---CDHIIHMVGQTSap--------tITSSVEKVLKECERlqVTTVSFPALGTGAGGLKPEVVIESMLIAFENHLS 1405 elephant shark
XP_013090473  943 GNLp---CQHIFFACMSRYrpds----esyLEKLVGKMLQEADNlkAKSISIPALGTGKLGYPADVVANVMKEAISKFSK 1015 Biomphalaria ...
XP_013397857  778 SGKlpesCKEVYHMVCQQYkpgh----ektLRAMVEECLKMAAKskHPSISFPSVGCGGLHFPPPLVAKTMFDVIMKFAG 853  Lingula anatina
Feature 1                        #      #           
5AIL_A        149 dhv--khQLTVKFVIFptd-leIYKAFSSEMAKR 179  human
3Q71_A        183 knq-lktLQEVHFLLHpsd-heNIQAFSDEFARR 214  human
3V2B_A        163 qhs-tpsLKTVKVVIFqp---eLLNIFYDSMKKR 192  human
4ABK_A        152 kgs-aqsVKKVKVVIFlp---qVLDVFYANMKKR 181  human
AAP91749      213 yrk-ptyLNCIKIPAYdvkvfnGLVKFFDKPPRF 245  Ciona intestinalis
XP_002125042  441 t-----nLKNIRLVIFptd-ifALQVISCVFNET 468  vase tunicate
NP_001107919 1344 ktp-qssLKLIRLVVFqa---hMLPEFLKSMQNR 1373 zebrafish
XP_007894519 1406 qtn-psvIKFIYIDIFep---kMFDPFVDALKWQ 1435 elephant shark
XP_013090473 1016 rk---tsVQSIKFVVYpad-rdVFQSFSSVLPSV 1045 Biomphalaria glabrata
XP_013397857  854 gegakssVKYINLIVWep---rTYGAFLEELKSR 884  Lingula anatina

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