1SLY,4OWD,2Y8P,4FDY,1D0K


Conserved Protein Domain Family
LT-like
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cd00254: LT-like 
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lytic transglycosylase(LT)-like domain
Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.
Links
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Statistics
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PSSM-Id: 381594
Aligned: 223 rows
Threshold Bit Score: 44.1263
Created: 16-Aug-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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sugar bindingcatalytic
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:sugar binding site [chemical binding site]
Evidence:
  • Structure:1SLY: Escherichia coli soluble lytic transglycosylase binds bulgecin A; contacts at 4A
  • Comment:bulgecin A is a sulphonated N-acetyl-D-glucosamine unit linked to a 4-hydroxy-5-hydroxymethylproline ring by a beta-glycosidic linkage
  • Citation:PMID 7823320
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #                      ###  #                               #         
1SLY_A       468 QSYAMAIARQESAwnpk-----vkspVGASGLMQIMPGTAthtvkmfsipgysspgqlLDPETNINIGTSYLQYvyqq-- 540 Escherichia coli
CDI03145     100 PLLVHAVISQESRynpr-----alspVGAGGLMQMMPGTAarfgl--------tsaerFEPHKNIRAGIRYLKVltrl-- 164 Candidatus Comp...
ADK83748      89 PATVMAVLAVESRfrph-----aispDGALGLMQIMPGTAsslgfk-------saaeaMDPIANLRAGIDYLAKlkrk-- 154 Desulfarculus b...
WP_009117186  38 ANLVWAVMARESGgrwn-----atshKNARGLLQVIPPTAarmgv--------npkylYNPEHNIIAGTRYLRFlsnr-- 102 Neisseria wadsw...
EET83871      37 PKLVTAIMARESAfkpn-----arspKDARGLMQVIPSTArmvgv--------dprrlFEPEQSIIAGTRYLAFlnkr-- 101 Acinetobacter r...
AFS54407      54 PVLVAAVIERESRfnshkfrrerrihDISRGLMQVTYRTArwlgfr------gapqklYNPWVNIRYGTKYLAYllkr-- 125 Leptospirillum ...
AHE97182     668 RGTIWALTRTESNhdpn-----avshAGAMGIAQFMPGTArdmg----------lndpFDPYASIEAAGRYMRHlldqp- 731 Thioalkalivibri...
WP_005037723 467 PAFVLAVMKNESQfqps-----atsgAKAMGLLQLLKPTFvsmvg--------rnadiRDPETNIRAALRYFKRiaktas 533 Holophaga foetida
NP_773294     70 EALVHRVIMRESRyqpg-----lvghGGTIGLMQIKLATArglgyt------gdaaglRDPNTNLTYAVKYLAG------ 132 Bradyrhizobium ...
ADD68700      39 PKLIHIMINVESKgrq--------faISRTGAMGLMQVMPttffdi-------adgdpFLAEDNIDAGVRYFTTqyrr-- 101 Denitrovibrio a...

Feature 1                               ##                                                  
1SLY_A       541 -----fgnnRIFSSAA-------YNAGlgrvrtwlgnsagrid-------avafvesipfsetrgYVKNvLAYDA 596 Escherichia coli
CDI03145     165 -----fgghLDLILAG-------YNAGegavlkygrq-------------------ippyketqqYVRRvKGYYA 208 Candidatus Competiba...
ADK83748     155 -----ysgdLNLALAA-------YNAGpgmisrhgg--------------------mppfeetqkYVQLvLSERE 197 Desulfarculus baarsi...
WP_009117186 103 -----yngnIDLMLAG-------YNAGegavdkykg--------------------ippyretqnYVRLvRNRYA 145 Neisseria wadsworthii
EET83871     102 -----fngnLIKIIAG-------YNAGhgavekfgg--------------------ippyretrnYVTYvTSKYQ 144 Acinetobacter radior...
AFS54407     126 ------yanVSDALAA-------YNDGrprkrhgryv------------------sssgsfsvdhYVRAiLSNTK 169 Leptospirillum ferri...
AHE97182     732 -----yihtLQDALAS-------YNAGpgnfrdrgay------------------ywreptehreRFERhFSAYQ 776 Thioalkalivibrio par...
WP_005037723 534 lqgepeairYAYIVAG-------YHAGegrakrwhaesqarfgsrtgpaemllrteaipftstrqYVLRvLGDRR 601 Holophaga foetida
NP_773294    133 ---------AYRAANGdharavrYFAGgy-----------------------------------yYVAK-RQRQE 162 Bradyrhizobium diazo...
ADD68700     102 ------fkrIDLALAA-------YNAGpqrvkdgkv---------------------pdfgetrhYIKRiMDVYV 142 Denitrovibrio acetip...

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