Conserved Protein Domain Family
bHLH_TS_NeuroD4_ATOH3
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cd19721: bHLH_TS_NeuroD4_ATOH3 
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) and similar proteins
NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation.
Links
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Statistics
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PSSM-Id: 381564
Aligned: 6 rows
Threshold Bit Score: 132.513
Created: 28-Jun-2018
Updated: 10-Sep-2024
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus NeuroD1 (2QL2) and E47 heterodimer binds DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           #  ## # #  #                   ##            
Q9HD90        59 EEEEDGEK-PKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIW 137 human
P79920        50 EEEEDGEK-PKKRGPKKKKMTKARVERFRVRRVKANARERSRMHGLNDALENLRRVMPCYSKTQKLSKIETLRLARNYIW 128 African clawed ...
6685684       59 EEEDDGEK-PKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIW 137 chicken
JC7999        67 EMGLDGEKaPKRRGPKKKKMTKARQERFRARRIKANARERSRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIW 146 zebrafish
XP_005999362  62 EGEADGEK-PKRRGPKKKKMTRARLERFKARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIW 140 coelacanth
XP_007884325  69 EEEEDGPK-PTRRGPKKRKVTKARVERFKARRLKANARERSRMHGLNAALDNLRKVMPCYSKTQKLSKIETLRLASNYIW 147 elephant shark

Feature 1                
Q9HD90       138 ALSEVLET 145 human
P79920       129 ALSDILEQ 136 African clawed frog
6685684      138 ALSEVLET 145 chicken
JC7999       147 ALSEVLES 154 zebrafish
XP_005999362 141 ALSETLET 148 coelacanth
XP_007884325 148 TLSEILQT 155 elephant shark

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