5V0L,4ZP4,5NJ8,5Y7Y


Conserved Protein Domain Family
bHLH-PAS_ARNT
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cd18947: bHLH-PAS_ARNT 
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basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
ARNT, also termed Class E basic helix-loop-helix protein 2 (bHLHe2), or Dioxin receptor, nuclear translocator, or hypoxia-inducible factor 1-beta (HIF1b), or HIF-1-beta, or HIF1-beta, is a member of bHLH-PAS transcription regulators that acts as the heterodimeric partner for bHLH-PAS proteins such as aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), and single-minded (SIM). These bHLH-PAS transcription complexes are involved in transcriptional responses to xenobiotic, hypoxia, and developmental pathways. Heterodimerization of bHLH-PAS proteins with ARNT is mediated by contacts between both the bHLH and the tandem PAS domains. ARNT use bHLH and/or PAS domains to interact with several transcriptional coactivators. It is required for activity of the aryl hydrocarbon (dioxin) receptor.
Links
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Statistics
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PSSM-Id: 381517
Aligned: 22 rows
Threshold Bit Score: 130.299
Created: 11-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingdimer interface
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:5V0L; Homo sapiens AhR-ARNT complex binds DNA, contacts at 4A.
  • Structure:5NJ8; Homo sapiens Aryl hydrocarbon receptor nuclear translocator binds DNA, contacts at 4A.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ##  ##  #  ##   #                    ##                      
5V0L_A        19 KERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 83  human
O02219        41 KERFARENHSEIERRRRNKMTHYINELAEMVPQCASLGRKPDKLTILRMAVSHMKGIRGHTAQDE 105 Caenorhabditis elegans
NP_001071655  15 KEKFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKQLRGAMGGGV 79  Ciona intestinalis
XP_002416629  20 TLSAKKENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKSLRGGTAPEE 84  black-legged tick
EFX90009      47 KERFARENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNTSA 111 common water flea
CCD58941      44 KERYARESHCEIERRRRNKMTAYINELCEMVPTCSSLARKPDKLTILRMAVSHMKSIRGTGSTTS 108 Schistosoma mansoni
O15945        10 ERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNTSS 74  fruit fly
KOF88349      56 KERFARESHCEIERRRRNKMTAYINELCDMVPTCSTLARKPDKLTILRMAVSHMKTLRGTGNTSN 120 Octopus bimaculoides
XP_013385138  45 KERFARESHCEIERRRRNKMTAYMSELCDMIPSCSSLARKPDKLTILRMAGSYMKTLRGTGNTSS 109 Lingula anatina
XP_014347039  76 KERFARENHSEIERRRRNKMTAYITELSDMVPSCSALARKPDKLTILRMAVAHMKSLRGTGNTST 140 coelacanth

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