Conserved Protein Domain Family
bHLH-O_HEY2
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cd18920: bHLH-O_HEY2 
basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) and similar proteins
HEY2, also termed cardiovascular helix-loop-helix factor 1 (CHF-1), or Class B basic helix-loop-helix protein 32 (bHLHb32), or HES-related repressor protein 2, or hairy and enhancer of split-related protein 2 (HESR-2), or hairy-related transcription factor 2 (HRT-2), or protein gridlock homolog, is a bHLH-O transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. As a downstream effector of Notch signaling, HEY2 may be required for cardiovascular development. It also plays an important role in neurologic development, as well as in the progression of human cancers.
Links
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Statistics
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PSSM-Id: 381490
Aligned: 6 rows
Threshold Bit Score: 159.535
Created: 1-May-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
putative dimerputative DNA
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens HES-1 (2MH3) forms a homodimer.
  • Comment:HLH region of bHLH forms homo- and heterodimers
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            ## ### ## ##  ##  #       # ###  ## ## ### ##  #            
Q9UBP5        40 PTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAM 119 human
KFV77215      40 PTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHSLAM 119 downy woodpecker
Q9I9L0        40 PTTTSQVMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHSLAM 119 zebrafish
XP_006003332  40 PTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAM 119 coelacanth
OCA33836      40 PTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAM 119 western clawed ...
XP_007897506  40 PSTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLRATGGKGFFDAHALAM 119 elephant shark

Feature 1          
Q9UBP5       120 DF 121 human
KFV77215     120 DF 121 downy woodpecker
Q9I9L0       120 DF 121 zebrafish
XP_006003332 120 DF 121 coelacanth
OCA33836     120 DF 121 western clawed frog
XP_007897506 120 DF 121 elephant shark

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