Conserved Protein Domain Family
bHLH-O_HEYL
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cd11447: bHLH-O_HEYL 
basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif-like protein (HEYL) and similar proteins
HEYL, also termed Class B basic helix-loop-helix protein 33 (bHLHb33), or hairy-related transcription factor 3 (HRT-3), is a bHLH-O transcriptional repressor that is strongly expressed in the presomitic mesoderm, the somites, the peripheral nervous system and smooth muscle of all arteries and is a downstream effector of the Notch and transforming growth factor-beta pathways. It promotes neuronal differentiation by activating proneural genes and inhibiting other hairy and enhancer of split (HES) and hairy/enhancer-of-split related with YRPW motif protein (HEY) proteins. HEYL also functions as a tumor suppressor involved in the progression of human cancers.
Links
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Statistics
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PSSM-Id: 381453
Aligned: 3 rows
Threshold Bit Score: 153.327
Created: 14-Jun-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
putative dimerputative DNA
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens HES-1 (2MH3) forms a homodimer.
  • Comment:HLH region of bHLH forms homo- and heterodimers
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           ## ### ## ##  ##  #       # ###  ## ## ### ##  #       
Q9NQ87        36 PSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDA 109 human
XP_005993953  36 TISSQILARKKRRGIIEKRRRDRINNSLSELRRLVPTAFQKQGSSKLEKAEILQMTVDHLKMLHATGGKGYFDA 109 coelacanth
KQK74392      74 TTTSQIQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEILQMTVDHLKMLHATGGAGKXCS 147 blue-fronted amazon

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