Conserved Protein Domain Family
bHLHzip_scHMS1_like
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cd11399: bHLHzip_scHMS1_like 
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription factor HMS1 and similar proteins
HMS1, also termed high-copy MEP suppressor protein 1, is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation.
Links
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Statistics
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PSSM-Id: 381405
Aligned: 9 rows
Threshold Bit Score: 132.983
Created: 28-Nov-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Homo sapiens SREBP1 (1AM9) bHLHzip binds DNA.
  • Citation:PMID 9634703
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            # ### ## ###   #                                             ##              
Q12398        265 RTGRVSHNIIEKKYRSNINDKIEQLRRTVPTLRvaykkcndlpit---srdladldglePATKLNKASILTKSIEYICHL 341  Saccharomyces...
O43019        425 LSKRSAHNMIEKRYRSNLNDKIAELRDAVPTLRsgynsttad---------elkgtyvpLSRKLNKATILSKATEYIKSL 495  fission yeast
CAE85553      301 PVKKTAHNMIEKRYRTNLNDKIAALRDSVPALRimsksargedt----tedreelhgltPAHKLNKATVLSKATEYIRHL 376  Neurospora cr...
Q9UUD1        259 KPKKTAHNMIEKRYRTNLNDRICELRDAVPSLRaaaalrcgns------lddedlggltPARKLNKGTILAKATEYIRHL 332  fission yeast
XP_022204491  212 PVKKTAHNMIEKRYRTNINDKIAALRDSVPSLRimsksargedt----tedreelhgltPAHKLNKATVLSKATEYIRHL 287  brown plantho...
EMT74505      203 PPKKTAHNMIEKRYRTNLNDKIAALRDSVPALRvmvhrleqpctenmdedadedlgglaPAHKLNKATILSKATEYIAHL 282  Arthrobacter
SHO77218      261 WSKKTAHNAIERRYRSNINDRIAGLRDVVPALRemrprdgrrkrrrgkaeteelvdgvtAATKLSKAAVLTKATEYICYL 340  Malassezia sy...
KJE95452      500 TEKKSAHNVIERRYRNSINDRILELRDVVPVCReaaamv--------------aagtntVKIKLNKATILRKAIEYIVFL 565  Capsaspora ow...
XP_001746319  253 MDKKMAHNAVERRYRNSINDRITHLRRLLPPTWtt-----------------------gPKVRTNKAAILQKVTAYLHFL 309  Monosiga brev...

Feature 1                               
Q12398        342 ERKCLQLSLANQHLSNDTRDSF 363  Saccharomyces cerevisiae S288c
O43019        496 QSKNKKLIEENKILQKRLSEYT 517  fission yeast
CAE85553      377 EKRNNRLIEENNSMHARIAAFE 398  Neurospora crassa
Q9UUD1        333 EAKNKELQKTNKQLSDRLAFYE 354  fission yeast
XP_022204491  288 EKRNSRLLDENNAMKERIAAFE 309  brown planthopper
EMT74505      283 EKKNKSLARENSQLRNRVEGFE 304  Arthrobacter
SHO77218      341 KSREVQLSREVAGLHMLIRSLD 362  Malassezia sympodialis ATCC 42132
KJE95452      566 QGSLERSRHEKATMQHALEMHG 587  Capsaspora owczarzaki ATCC 30864
XP_001746319  310 IENNQELHREVTSLREVLAAHG 331  Monosiga brevicollis MX1

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